PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17904146-9	2008	Addition of simvastatin significantly reduced CD40 expression as well as platelet adhesion to fibrillating atria; its efficacy was not reversed by the addition of mevalonic acid.	Simvastatin	12-23	CD40 molecule	Homo sapiens	46-50	
17046792-0	2006	Simvastatin reduces CD40 expression in an experimental model of early arterialization of saphenous vein graft.	Simvastatin	0-11	CD40 molecule	Homo sapiens	20-24	
17046792-11	2006	CONCLUSIONS: Simvastatin treatment modulates endothelial CD40-sCD40L in both venous and arterial grafts, and therefore may represent a useful tool in the pharmacological prevention of graft failure.	Simvastatin	13-24	CD40 molecule	Homo sapiens	57-61	
25311809-5	2014	Inhibition of 3-hydroxy-3-methylglutaryl CoA reductase, the rate-limiting enzyme of the mevalonate pathway, by lipophilic statins such as simvastatin and atorvastatin resulted in a specific inhibition of B cell activation via CD40 and impaired their ability to act as stimulatory APCs for allospecific T cells.	Simvastatin	138-149	CD40 molecule	Homo sapiens	226-230	
22298164-0	2012	Simvastatin and atorvastatin attenuate VCAM-1 and uPAR expression on human endothelial cells and platelet surface expression of CD40 ligand.	Simvastatin	0-11	CD40 molecule	Homo sapiens	128-132	
15936988-4	2005	Moreover, simvastatin concentration-dependently inhibited the expression of ICAM-1 and induced the expression of CD40 on monocytes.	Simvastatin	10-21	CD40 molecule	Homo sapiens	113-117	
15936988-5	2005	In the presence of IL-18, simvastatin suppressed the expression of ICAM-1 and CD40 as well as the production of IL-12, TNF-alpha and IFN-gamma in PBMC, contributing to the anti-inflammatory effect of simvastatin.	Simvastatin	26-37	CD40 molecule	Homo sapiens	78-82	
15311154-10	2004	Treatment with simvastatin might downregulate enhanced CD40L-CD40 interactions in CAPD patients.	Simvastatin	15-26	CD40 molecule	Homo sapiens	55-59