PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19410078-3	2009	The study assessed the effect of simvastatin on tumor necrosis factor alpha (TNF- alpha)-induced synthesis of Cyr61 and CCL2 in MG-63 human osteoblastic cells.	Simvastatin	33-44	cellular communication network factor 1	Homo sapiens	110-115	
20191585-0	2011	Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells: a therapeutic benefit for arthritis.	Simvastatin	0-11	cellular communication network factor 1	Homo sapiens	41-46	
20191585-7	2011	RESULTS: In primary human osteoblasts and U2OS cells, Cyr61 expression stimulated by tumor necrosis factor alpha, interleukin-1beta (IL-1beta), oncostatin M (OSM), and other IL-6-family cytokines was suppressed by simvastatin.	Simvastatin	214-225	cellular communication network factor 1	Homo sapiens	54-59	
20191585-10	2011	OSM-induced Cyr61 promoter activation was dependent on CRE-CREB interaction and inhibited by simvastatin.	Simvastatin	93-104	cellular communication network factor 1	Homo sapiens	12-17	
20191585-12	2011	Intraarticular injection of simvastatin inhibited CIA progression and diminished the number of Cyr61+ osteoblasts and infiltrating macrophages.	Simvastatin	28-39	cellular communication network factor 1	Homo sapiens	95-100	
20191585-13	2011	CONCLUSION: Simvastatin inhibited cytokine-stimulated Cyr61 expression in osteoblastic cells and suppressed disease progression and osteoblastic expression of Cyr61 in inflammatory arthritis.	Simvastatin	12-23	cellular communication network factor 1	Homo sapiens	54-59	
20191585-13	2011	CONCLUSION: Simvastatin inhibited cytokine-stimulated Cyr61 expression in osteoblastic cells and suppressed disease progression and osteoblastic expression of Cyr61 in inflammatory arthritis.	Simvastatin	12-23	cellular communication network factor 1	Homo sapiens	159-164	
29236027-10	2017	The EGF-induced increases of Cyr61 protein expression and cell migration were prevented by simvastatin.	Simvastatin	91-102	cellular communication network factor 1	Homo sapiens	29-34	
29236027-11	2017	Taken together, these results suggest that simvastatin induced ATC proliferation inhibition through the deactivation of RhoA/Rac1 protein and overexpression of p21cip and p27kip, and migration inhibition through the abrogation of Cyr61 protein expression.	Simvastatin	43-54	cellular communication network factor 1	Homo sapiens	230-235	
33542676-0	2021	Simvastatin Inhibits CYR61 Expression in Orbital Fibroblasts in Graves" Ophthalmopathy through the Regulation of FoxO3a Signaling.	Simvastatin	0-11	cellular communication network factor 1	Homo sapiens	21-26	
33542676-11	2021	The data revealed that simvastatin could inhibit TNF-alpha-induced CYR61 expression by modulating the activity of transcription factor FoxO3a.	Simvastatin	23-34	cellular communication network factor 1	Homo sapiens	67-72	
31100067-2	2019	Exposure of sparse cultures of PANC-1 and MiaPaCa-2 cells to cerivastatin or simvastatin induced a striking re-localization of YAP from the nucleus to the cytoplasm and inhibited the expression of the YAP/TEAD-regulated genes Connective Tissue Growth Factor (CTGF) and Cysteine-rich angiogenic inducer 61 (CYR61).	Simvastatin	77-88	cellular communication network factor 1	Homo sapiens	269-304	
31100067-2	2019	Exposure of sparse cultures of PANC-1 and MiaPaCa-2 cells to cerivastatin or simvastatin induced a striking re-localization of YAP from the nucleus to the cytoplasm and inhibited the expression of the YAP/TEAD-regulated genes Connective Tissue Growth Factor (CTGF) and Cysteine-rich angiogenic inducer 61 (CYR61).	Simvastatin	77-88	cellular communication network factor 1	Homo sapiens	306-311