PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30720104-8 2019 The addition of TMP and simvastatin demonstrated that, compared with the model group, the inflammatory factor levels and the ratio of p-NF-kappaB/NF-kappaB were decreased. Simvastatin 24-35 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 136-145 30720104-8 2019 The addition of TMP and simvastatin demonstrated that, compared with the model group, the inflammatory factor levels and the ratio of p-NF-kappaB/NF-kappaB were decreased. Simvastatin 24-35 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 146-155 22537532-10 2012 In particular, simvastatin was less effective in PPAR-alpha KO, compared to WT mice, as evaluated by inhibition of the degree of spinal cord inflammation, neutrophil infiltration, nitrotyrosine formation, pro-inflammmatory cytokine expression, nuclear factor (NF)-kappaB activation, inducible nitric-oxide synthase (iNOS) expression, and apoptosis. Simvastatin 15-26 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 244-270 29375693-0 2018 Simvastatin improves intracerebral hemorrhage through NF-kappaB-mediated apoptosis via the MyD88/TRIF signaling pathway. Simvastatin 0-11 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 54-63 29375693-9 2018 Furthermore, the results revealed that NF-kappaB overexpression abolished the simvastatin-downregulated MyD88 and TRIF expression levels, as well as the apoptosis of neuronal cells. Simvastatin 78-89 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 39-48 29375693-10 2018 In conclusion, these results indicated that simvastatin was able to attenuate brain edema and reduce cellular apoptosis by suppressing the NF-kappaB-mediated MyD88/TRIF signaling pathway subsequent to the induction of intracerebral hemorrhage in mice. Simvastatin 44-55 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 139-148 17178392-0 2007 Simvastatin inhibits NF-kappaB signaling in intestinal epithelial cells and ameliorates acute murine colitis. Simvastatin 0-11 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 21-30 19864567-6 2009 Interestingly, simvastatin attenuated activation of both p21(ras) and NF-kappaB in MPP(+)-stimulated microglial cells. Simvastatin 15-26 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 70-79 19864567-8 2009 However, after oral administration, simvastatin entered into the nigra, reduced nigral activation of p21(ras), attenuated nigral activation of NF-kappaB, inhibited nigral expression of proinflammatory molecules, and suppressed nigral activation of glial cells. Simvastatin 36-47 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 143-152 17169357-6 2007 Our data suggest that simvastatin may be used as a therapeutic agent in asthma, based on reductions of various allergic responses via regulating small G proteins/MAP kinases/NF-kappaB in mouse allergic asthma. Simvastatin 22-33 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 174-183 18073186-10 2008 This study revealed that simvastatin-induced HO-1 led to increased NF-kappaB activation and superoxides production in the neuronal cells when exposed to LPS, and iron production may play a role in such a response. Simvastatin 25-36 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 67-76 17178392-5 2007 Simvastatin (50 micro M) blocked TNF-alpha-induced NF-kappaB transcriptional activity, IkappaB phosphorylation/degradation and DNA binding activity of NF-kappaB. Simvastatin 0-11 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 51-60 17178392-5 2007 Simvastatin (50 micro M) blocked TNF-alpha-induced NF-kappaB transcriptional activity, IkappaB phosphorylation/degradation and DNA binding activity of NF-kappaB. Simvastatin 0-11 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 151-160 17178392-7 2007 These results suggest that simvastatin inhibits proinflammatory gene expression by blocking NF-kappaB signaling in IEC, and attenuates DSS-induced acute murine colitis. Simvastatin 27-38 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 92-101