PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17169357-6	2007	Our data suggest that simvastatin may be used as a therapeutic agent in asthma, based on reductions of various allergic responses via regulating small G proteins/MAP kinases/NF-kappaB in mouse allergic asthma.	Simvastatin	22-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	174-183	
22537532-10	2012	In particular, simvastatin was less effective in PPAR-alpha KO, compared to WT mice, as evaluated by inhibition of the degree of spinal cord inflammation, neutrophil infiltration, nitrotyrosine formation, pro-inflammmatory cytokine expression, nuclear factor (NF)-kappaB activation, inducible nitric-oxide synthase (iNOS) expression, and apoptosis.	Simvastatin	15-26	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	244-270	
19864567-6	2009	Interestingly, simvastatin attenuated activation of both p21(ras) and NF-kappaB in MPP(+)-stimulated microglial cells.	Simvastatin	15-26	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	70-79	
19864567-8	2009	However, after oral administration, simvastatin entered into the nigra, reduced nigral activation of p21(ras), attenuated nigral activation of NF-kappaB, inhibited nigral expression of proinflammatory molecules, and suppressed nigral activation of glial cells.	Simvastatin	36-47	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	143-152	
30720104-8	2019	The addition of TMP and simvastatin demonstrated that, compared with the model group, the inflammatory factor levels and the ratio of p-NF-kappaB/NF-kappaB were decreased.	Simvastatin	24-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	136-145	
30720104-8	2019	The addition of TMP and simvastatin demonstrated that, compared with the model group, the inflammatory factor levels and the ratio of p-NF-kappaB/NF-kappaB were decreased.	Simvastatin	24-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	146-155	
29375693-0	2018	Simvastatin improves intracerebral hemorrhage through NF-kappaB-mediated apoptosis via the MyD88/TRIF signaling pathway.	Simvastatin	0-11	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	54-63	
29375693-9	2018	Furthermore, the results revealed that NF-kappaB overexpression abolished the simvastatin-downregulated MyD88 and TRIF expression levels, as well as the apoptosis of neuronal cells.	Simvastatin	78-89	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	39-48	
29375693-10	2018	In conclusion, these results indicated that simvastatin was able to attenuate brain edema and reduce cellular apoptosis by suppressing the NF-kappaB-mediated MyD88/TRIF signaling pathway subsequent to the induction of intracerebral hemorrhage in mice.	Simvastatin	44-55	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	139-148	
18073186-10	2008	This study revealed that simvastatin-induced HO-1 led to increased NF-kappaB activation and superoxides production in the neuronal cells when exposed to LPS, and iron production may play a role in such a response.	Simvastatin	25-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	67-76	
17178392-0	2007	Simvastatin inhibits NF-kappaB signaling in intestinal epithelial cells and ameliorates acute murine colitis.	Simvastatin	0-11	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	21-30	
17178392-5	2007	Simvastatin (50 micro M) blocked TNF-alpha-induced NF-kappaB transcriptional activity, IkappaB phosphorylation/degradation and DNA binding activity of NF-kappaB.	Simvastatin	0-11	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	51-60	
17178392-5	2007	Simvastatin (50 micro M) blocked TNF-alpha-induced NF-kappaB transcriptional activity, IkappaB phosphorylation/degradation and DNA binding activity of NF-kappaB.	Simvastatin	0-11	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	151-160	
17178392-7	2007	These results suggest that simvastatin inhibits proinflammatory gene expression by blocking NF-kappaB signaling in IEC, and attenuates DSS-induced acute murine colitis.	Simvastatin	27-38	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	92-101