PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18172037-6 2008 Rats infused long term with Ang II exhibited higher levels of activated Rac1, phospho-STAT3, collagen synthesis, and atrial fibrosis in the atria, all of which were attenuated by oral losartan and simvastatin. Simvastatin 197-208 angiotensinogen Rattus norvegicus 28-34 18091590-6 2007 Removal of simvastatin led to a rebound increase in mRNA-AT1-R (+39 +/- 2%, P < 0.01), AT1-R protein (+46 +/- 2%; P < 0.01), and AngII-mediated phosphorylation of ERK1/2 (+36 +/- 3%; P < 0.01). Simvastatin 11-22 angiotensinogen Rattus norvegicus 135-140 17463319-9 2007 Ang II (1 micromol/L, 2 hours) induced serine 133 phosphorylation of CREB and binding of CREB to CRE and increased LCC alpha1C subunit gene promoter activity through a protein kinase C/NADPH oxidase/reactive oxygen species pathway, which was blocked by the Ang II type 1 receptor blocker losartan and the antioxidant simvastatin. Simvastatin 317-328 angiotensinogen Rattus norvegicus 0-6 18091590-5 2007 In rat aortic vascular smooth muscle cells (VSMC), simvastatin (0.3 to 3 microM for 24 hours) resulted in concentration-dependent inhibition of AngII-stimulated phosphorylation of extracellular-signal regulated kinase 1/2 ERK1/2 (-67 +/- 5% with 3 microM; P < 0.001) and decreased AT1-R mRNA (-34 +/- 8% with 3 microM; P < 0.01) and AT1-R protein (-32 +/- 6% with 3 microM; P < 0.01). Simvastatin 51-62 angiotensinogen Rattus norvegicus 144-149 17592071-4 2007 In cultured vascular smooth muscle cells (VSMCs) atorvastatin and simvastatin inhibited Ang II-induced CTGF production. Simvastatin 66-77 angiotensinogen Rattus norvegicus 88-94 17878758-0 2007 Simvastatin reverses target organ damage and oxidative stress in Angiotensin II hypertension: comparison with apocynin, tempol, and hydralazine. Simvastatin 0-11 angiotensinogen Rattus norvegicus 65-79 17878758-1 2007 The ability of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor simvastatin to reverse established cardiovascular and renal alterations and oxidative stress was assessed in angiotensin II (AngII) hypertension. Simvastatin 70-81 angiotensinogen Rattus norvegicus 179-193 17878758-1 2007 The ability of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor simvastatin to reverse established cardiovascular and renal alterations and oxidative stress was assessed in angiotensin II (AngII) hypertension. Simvastatin 70-81 angiotensinogen Rattus norvegicus 195-200 17878758-9 2007 Our results indicate that simvastatin reverse established cardiac and renal alterations in AngII hypertension independently of arterial pressure. Simvastatin 26-37 angiotensinogen Rattus norvegicus 91-96 17463319-10 2007 In the rat model, Ang II infusion increased LCC alpha1C subunit expression and serine 133 phosphorylation of CREB, which were attenuated by oral losartan and simvastatin. Simvastatin 158-169 angiotensinogen Rattus norvegicus 18-24 17161379-5 2007 Pretreatment with 1-3 microM simvastatin for 24h inhibited AII-mediated stimulation of ERK1/2 and p38 MAPK phosphorylation; without affecting the levels on non-phosphorylated MAPK. Simvastatin 29-40 angiotensinogen Rattus norvegicus 59-62 17161379-6 2007 Washout of simvastatin produced a rebound increase above control levels of AII-mediated phosphorylation of ERK1/2 and p38 MAPK. Simvastatin 11-22 angiotensinogen Rattus norvegicus 75-78 16449352-1 2006 In the current study, we investigated the effect of simvastatin on the ability of high glucose (HG) and ANG II to activate the JAK2-STAT signaling cascade and induce glomerular mesangial cell (GMC) growth. Simvastatin 52-63 angiotensinogen Rattus norvegicus 104-110 16449352-2 2006 We found that pretreatment with simvastatin significantly inhibited HG- and ANG II-induced collagen IV production, JAK2 activation, and phosphorylation of STAT1 and STAT3 in GMC. Simvastatin 32-43 angiotensinogen Rattus norvegicus 76-82 16449352-5 2006 This study demonstrates that simvastatin blocks ANG II-induced activation of the JAK/STAT pathway in the diabetic environment, in vitro and in vivo, and, thereby, provides new insights into the molecular mechanisms underlying early diabetic nephropathy. Simvastatin 29-40 angiotensinogen Rattus norvegicus 48-54 16628357-10 2006 However, cocultured with simvastatin significantly inhibited the cardiomyocyte [(3)H]leucine uptake induced by angiotensin II in a concentration-dependent manner. Simvastatin 25-36 angiotensinogen Rattus norvegicus 111-125 11794990-0 2001 [Simvastatin attenuates cardiovascular effects and oxidative stress induced by angiotensin II]. Simvastatin 1-12 angiotensinogen Rattus norvegicus 79-93 16280288-9 2005 Simvastatin, losartan, and the combination reduced renal Ang II, but only the combination reduced cardiac Ang II. Simvastatin 0-11 angiotensinogen Rattus norvegicus 57-63 14512087-5 2003 Pretreatment with simvastatin (0.03-3 microg/ml) significantly inhibited TF and PAI-1 induction by Ang II in a dose- and time-dependent manner. Simvastatin 18-29 angiotensinogen Rattus norvegicus 99-105 15213258-0 2004 Simvastatin modulates angiotensin II signaling pathway by preventing Rac1-mediated upregulation of p27. Simvastatin 0-11 angiotensinogen Rattus norvegicus 22-36 15213258-3 2004 The current study explored the modulatory effects of simvastatin (SMV) on the angiotensin II (Ang II)-induced Rac1-mediated, upregulation of cyclin-dependent kinase inhibitor p27. Simvastatin 53-64 angiotensinogen Rattus norvegicus 78-100 15213258-3 2004 The current study explored the modulatory effects of simvastatin (SMV) on the angiotensin II (Ang II)-induced Rac1-mediated, upregulation of cyclin-dependent kinase inhibitor p27. Simvastatin 66-69 angiotensinogen Rattus norvegicus 78-100 15213258-5 2004 Co-treatment of cells with SMV (1 microM) inhibited Ang II-induced upregulation of p27 protein. Simvastatin 27-30 angiotensinogen Rattus norvegicus 52-58 15213258-8 2004 It was also shown that SMV, by inhibiting Rac1 activity, reversed Ang II-induced increase in intracellular H2O2 production, Akt activation, and p27 protein expression. Simvastatin 23-26 angiotensinogen Rattus norvegicus 66-72 15213258-9 2004 The data presented in this study not only elucidate Ang II-mediated signaling cascade in mesangial cells but also demonstrate for the first time the modulatory effects of SMV on Ang II-induced signaling pathway at the cell cycle level. Simvastatin 171-174 angiotensinogen Rattus norvegicus 52-58 15213258-9 2004 The data presented in this study not only elucidate Ang II-mediated signaling cascade in mesangial cells but also demonstrate for the first time the modulatory effects of SMV on Ang II-induced signaling pathway at the cell cycle level. Simvastatin 171-174 angiotensinogen Rattus norvegicus 178-184 14512087-7 2003 Both Rho inhibitor, C3 exoenzyme, and Rho kinase inhibitor, Y-27632, mimicked the inhibitory effects of simvastatin against TF and PAI-1 induced by Ang II. Simvastatin 104-115 angiotensinogen Rattus norvegicus 148-154 14512087-9 2003 CONCLUSION: It was indicated that simvastatin maintains endothelial cells to be antithrombotic by inhibiting TF and PAI-1 expression via the Rho/Rho kinase pathways in which AngII induces TF and PAI-1 expression. Simvastatin 34-45 angiotensinogen Rattus norvegicus 174-179 12154104-0 2002 Simvastatin prevents angiotensin II-induced cardiac alteration and oxidative stress. Simvastatin 0-11 angiotensinogen Rattus norvegicus 21-35 12154104-1 2002 The influence of the HMG-CoA reductase inhibitor simvastatin was assessed on the cardiovascular alterations and production of free radicals associated with chronic angiotensin II (Ang II) infusion. Simvastatin 49-60 angiotensinogen Rattus norvegicus 164-178 12154104-1 2002 The influence of the HMG-CoA reductase inhibitor simvastatin was assessed on the cardiovascular alterations and production of free radicals associated with chronic angiotensin II (Ang II) infusion. Simvastatin 49-60 angiotensinogen Rattus norvegicus 180-186 12154104-2 2002 Simvastatin (60 mg/kg per day PO) or placebo were given concomitantly for 10 days in Sprague-Dawley rats infused with Ang II (200 ng/kg per minute SC, osmotic pump). Simvastatin 0-11 angiotensinogen Rattus norvegicus 118-124 12154104-7 2002 Increases in heart weight index and carotid cross-sectional area induced by Ang II were obliterated by simvastatin (3.18+/-0.09 versus 3.46+/-0.11 mg/g body wt and 0.125+/-0.010 versus 0.177+/-0.010 mm2, respectively). Simvastatin 103-114 angiotensinogen Rattus norvegicus 76-82 12154104-8 2002 The Ang II-induced increases in leukocyte and aortic production of ROS as well as protein and lipid oxidation products were prevented by simvastatin. Simvastatin 137-148 angiotensinogen Rattus norvegicus 4-10 12154104-10 2002 These results indicate that simvastatin prevented the development of hypertension and cardiovascular hypertrophy together with inhibition of the induced angiotensin II production of ROS. Simvastatin 28-39 angiotensinogen Rattus norvegicus 153-167 11794990-7 2001 The overproduction of TBARS induced by ANG II was partially prevented by simvastatin (598 +/- 40 vs 794 +/- 79 pmol/mL). Simvastatin 73-84 angiotensinogen Rattus norvegicus 39-45 11794990-8 2001 These results indicate that simvastatin attenuates the cardiovascular effects and lipid peroxidation induced by chronic administration of angiotensin II. Simvastatin 28-39 angiotensinogen Rattus norvegicus 138-152 11714734-4 2001 We treated neonatal rat cardiac myocytes with angiotensin II (AngII) with and without simvastatin (Sim) and found that Sim decreased AngII-induced protein content, [3H] leucine uptake, and atrial natriuretic factor (ANF) promoter activity. Simvastatin 86-97 angiotensinogen Rattus norvegicus 133-138 11714734-4 2001 We treated neonatal rat cardiac myocytes with angiotensin II (AngII) with and without simvastatin (Sim) and found that Sim decreased AngII-induced protein content, [3H] leucine uptake, and atrial natriuretic factor (ANF) promoter activity. Simvastatin 119-122 angiotensinogen Rattus norvegicus 46-60 11714734-4 2001 We treated neonatal rat cardiac myocytes with angiotensin II (AngII) with and without simvastatin (Sim) and found that Sim decreased AngII-induced protein content, [3H] leucine uptake, and atrial natriuretic factor (ANF) promoter activity. Simvastatin 119-122 angiotensinogen Rattus norvegicus 62-67 11714734-4 2001 We treated neonatal rat cardiac myocytes with angiotensin II (AngII) with and without simvastatin (Sim) and found that Sim decreased AngII-induced protein content, [3H] leucine uptake, and atrial natriuretic factor (ANF) promoter activity. Simvastatin 119-122 angiotensinogen Rattus norvegicus 133-138 11714734-8 2001 Indeed, Sim inhibited cardiac hypertrophy and decreased myocardial Rac1 activity and O2*- production in rats treated with AngII infusion or subjected to transaortic constriction. Simvastatin 8-11 angiotensinogen Rattus norvegicus 122-127 11868908-6 2001 The results indicate that simvastatin-induced apoptosis in cultured heart cells is concentration-dependent and additive to the apoptotic effect of angiotensin II. Simvastatin 26-37 angiotensinogen Rattus norvegicus 147-161 10413074-6 1999 In cultured rat aortic smooth muscle cells loaded with fura-2, increases in intracellular free-Ca2+ concentration ([Ca2+]i) induced by angiotensin II were markedly inhibited in cells incubated with simvastatin and atorvastatin but not pravastatin. Simvastatin 198-209 angiotensinogen Rattus norvegicus 135-149 10440099-5 1999 Lipid-soluble HMG-CoA reductase inhibitors, lovastatin (10(-6) M) and simvastatin (10(-6) M) partially and significantly inhibited the angiotensin II-induced increases in these parameters, but a water-soluble HMG-CoA reductase inhibitor, pravastatin (10(-6) M) did not. Simvastatin 70-81 angiotensinogen Rattus norvegicus 135-149 10440099-6 1999 Mevalonate (10(-4) M) overcame the inhibitory effects of lovastatin and simvastatin on angiotensin II-induced increases in these parameters. Simvastatin 72-83 angiotensinogen Rattus norvegicus 87-101 10561812-17 1999 Compared with the LVH group, in the simvastatin-treated and ACE inhibitor groups ACE activity was reduced by 36 (P < 0.05) and 48% (P < 0.01), respectively, AngII content was reduced by 11 (P < 0.05) and 43% (P < 0.01), respectively, and hydroxyproline content was reduced by 23 (P < 0.01) and 10% (P < 0.05), respectively. Simvastatin 36-47 angiotensinogen Rattus norvegicus 163-168 22233179-3 2012 In the present study we tested the hypothesis that simvastatin affects haemodynamic responses to air-jet stress and intracerebroventricular infusions of vasopressin and AngII. Simvastatin 51-62 angiotensinogen Rattus norvegicus 169-174 12013483-3 1996 The tension (g) developed by angiotensin II (100 nmol/l) was measured under basal conditions and after 45 min incubation with 20 micromol/l simvastatin. Simvastatin 140-151 angiotensinogen Rattus norvegicus 29-43 12013483-6 1996 Treatment of aortic rings with simvastatin inhibited the angiotensin II-induced contraction 58 +/- 0.06%. Simvastatin 31-42 angiotensinogen Rattus norvegicus 57-71 12013483-13 1996 Simvastatin, lovastatin and mevastatin significantly reduced the angiotensin II-induced calcium mobilization. Simvastatin 0-11 angiotensinogen Rattus norvegicus 65-79 29460135-3 2018 In the presence of simvastatin, CA secretion evoked by 1.1-dimethyl-4-phenyl piperazinium iodide (DMPP), angiotensin II, high K+, veratridine, and Bay-K-8644 was time-dependently inhibited. Simvastatin 19-30 angiotensinogen Rattus norvegicus 105-119 29460135-4 2018 However, in the simultaneous presence of simvastatin and Nomega-nitro-L-arginine methyl ester hydrochloride, CA secretion evoked by angiotensin II and DMPP recovered to control levels. Simvastatin 41-52 angiotensinogen Rattus norvegicus 132-146 25492829-5 2014 Controls and simvastatin and pravastatin groups showed a significant increase in mean arterial BP and heart rate in response to Ang II. Simvastatin 13-24 angiotensinogen Rattus norvegicus 128-134 25492829-7 2014 In contrast, when pretreated with hexamethonium, a ganglionic blocker, simvastatin and pravastatin groups showed a similar hypertensive response to Ang II, which was smaller than in controls. Simvastatin 71-82 angiotensinogen Rattus norvegicus 148-154 25492829-8 2014 Likewise, the Ang II-induced vasoconstrictor response of femoral artery branches was comparable between simvastatin and pravastatin groups and smaller than in controls. Simvastatin 104-115 angiotensinogen Rattus norvegicus 14-20 25492829-10 2014 This study shows that simvastatin and pravastatin differ in their effects on the Ang II-dependent mechanisms controlling BP. Simvastatin 22-33 angiotensinogen Rattus norvegicus 81-87 22233179-7 2012 In rats given 60 mg/L simvastatin, the hypertensive response to air-jet stress was significantly smaller than in controls, as was the increase in MAP in response to AngII. Simvastatin 22-33 angiotensinogen Rattus norvegicus 165-170 20489687-0 2010 Simvastatin reduces pressor response to centrally administered angiotensin II. Simvastatin 0-11 angiotensinogen Rattus norvegicus 63-77 22083280-0 2012 Simvastatin ameliorates angiotensin II-induced endothelial dysfunction through restoration of Rho-BH4-eNOS-NO pathway. Simvastatin 0-11 angiotensinogen Rattus norvegicus 24-38 22083280-8 2012 In cultured rat arterial endothelial cells, simvastatin restored BH4, GTPCH I activity and NO release impaired by angiotensin II, and pretreatment with mevalonate (MVA) or geranylgeranyl pyrophosphate (GGPP) abolished the beneficial effects exerted by simvastatin. Simvastatin 44-55 angiotensinogen Rattus norvegicus 114-128 21152444-5 2010 Treatment with atorvastatin or simvastatin inhibited AngII-induced Smad activation and related-fibrosis. Simvastatin 31-42 angiotensinogen Rattus norvegicus 53-58 20489687-11 2010 ICV infusion of Ang II elicited a significant increase in HR in the untreated group but not in the simvastatin group. Simvastatin 99-110 angiotensinogen Rattus norvegicus 16-22 20489687-13 2010 CONCLUSIONS: The results show that simvastatin reduces the pressor response to ICV-infused Ang II in rats. Simvastatin 35-46 angiotensinogen Rattus norvegicus 91-97 19298698-0 2009 Synergism of simvastatin with losartan prevents angiotensin II-induced cardiomyocyte apoptosis in vitro. Simvastatin 13-24 angiotensinogen Rattus norvegicus 48-62 19298698-10 2009 Losartan (10(-5) M) and simvastatin (10(-5) M), either alone or in combination, significantly decreased Ang II-induced cardiomyocyte apoptosis and increased cell viability. Simvastatin 24-35 angiotensinogen Rattus norvegicus 104-110 20117462-6 2010 In neonatal rat cardiomyocytes and fibroblasts, a specific small molecule inhibitor of Rac1 or simvastatin completely prevented the angiotensin II-induced up-regulation of CTGF, Cx43, and N-cadherin expression. Simvastatin 95-106 angiotensinogen Rattus norvegicus 132-146 19515066-0 2010 Simvastatin inhibits angiotensin II-induced cardiac cell hypertrophy: role of Homer 1a. Simvastatin 0-11 angiotensinogen Rattus norvegicus 21-35 19515066-9 2010 Homer 1a protein levels were upregulated following AngII-induced hypertrophy in H9C2 cells and neonatal rat cardiomyocytes, and these increases were augmented by simvastatin pretreatment. Simvastatin 162-173 angiotensinogen Rattus norvegicus 51-56 19515066-10 2010 Concomitantly, simvastatin pretreatment inhibited extracellular signal-regulated kinase (ERK) 1/2 phosphorylation and AngII-induced hypertrophy. Simvastatin 15-26 angiotensinogen Rattus norvegicus 118-123 19515066-12 2010 The inhibitory effects of simvastatin against AngII-induced hypertrophy were attenuated by Homer 1a silencing, suggesting that simvastatin suppresses cardiac hypertrophy in a Homer 1a-dependent manner. Simvastatin 26-37 angiotensinogen Rattus norvegicus 46-51 19515066-12 2010 The inhibitory effects of simvastatin against AngII-induced hypertrophy were attenuated by Homer 1a silencing, suggesting that simvastatin suppresses cardiac hypertrophy in a Homer 1a-dependent manner. Simvastatin 127-138 angiotensinogen Rattus norvegicus 46-51 19298698-15 2009 CONCLUSIONS: Our data provide the first evidence that synergism of simvastatin with losartan prevents angiotensin II-induced cardiomyocyte apoptosis in vitro. Simvastatin 67-78 angiotensinogen Rattus norvegicus 102-116 19298698-4 2009 Here, we demonstrate that Ang II-induced apoptosis is prevented by losartan and simvastatin in neonatal cardiomyocytes. Simvastatin 80-91 angiotensinogen Rattus norvegicus 26-32