PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26223190-11 2016 A single injection of the simvastatin/poloxamer 407 hydrogel significantly increased BMD, bone microstructure, and strength; the bone volume fraction and trabecular thickness increased nearly 150 %, bone strength almost doubled compared with controls (all P < 0.01); and induced higher expression of VEGF, BMP2, and osteocalcin. Simvastatin 26-37 bone gamma-carboxyglutamate protein Homo sapiens 319-330 15953866-12 2005 10(-6) M of simvastatin also significantly enhanced the osteocalcin mRNA expression level. Simvastatin 12-23 bone gamma-carboxyglutamate protein Homo sapiens 56-67 15129368-4 2004 In addition, PD098059 as well as simvastatin and the FTase inhibitor abolished alkaline phosphatase activity and/or osteocalcin mRNA induction by the IL-6/IL-6sR in these cells. Simvastatin 33-44 bone gamma-carboxyglutamate protein Homo sapiens 116-127 15221496-10 2004 In conclusion; 20-mg daily simvastatin treatment for 3 months significantly increased BAP and OCL levels (markers of bone formation) in hypercholesterolemic postmenopausal subjects, without affecting bone resorption. Simvastatin 27-38 bone gamma-carboxyglutamate protein Homo sapiens 94-97 11549708-0 2001 Simvastatin increases serum osteocalcin concentration in patients treated for hypercholesterolaemia. Simvastatin 0-11 bone gamma-carboxyglutamate protein Homo sapiens 28-39 11549708-6 2001 Our data support that simvastatin causes a beneficial effect on bone metabolism as reflected by an increase in serum osteocalcin concentration. Simvastatin 22-33 bone gamma-carboxyglutamate protein Homo sapiens 117-128 34067739-7 2021 In contrast, SIM-induced osteogenesis in ADSCs was reduced in SIM plus HAM, including mRNA expression of osteogenic genes, osteocalcin and alkaline phosphatase (ALP), ALP activity and mineralization. Simvastatin 13-16 bone gamma-carboxyglutamate protein Homo sapiens 123-134 31471919-7 2020 Moreover, simvastatin treatment upregulated the expression of genes related to osteogenic maturation, such as runt-related transcription factor 2, osteopontin, and osteocalcin, and increased the mineralization of the extracellular matrix in GCTB stromal cells. Simvastatin 10-21 bone gamma-carboxyglutamate protein Homo sapiens 164-175 31245876-7 2019 Our results indicated that simvastatin increased alkaline phosphatase (ALP) activity; mineralization of extracellular matrix; mRNA expression of ALP, COL1, and OCN; and expression and nuclear translocation of Gli1. Simvastatin 27-38 bone gamma-carboxyglutamate protein Homo sapiens 160-163 24555011-8 2013 The relative expression and secretion of osteocalcin was significantly increased by cells cultured on scaffolds with 10 microM simvastatin when compared to scaffolds without simvastatin after 21 days. Simvastatin 127-138 bone gamma-carboxyglutamate protein Homo sapiens 41-52 26499955-5 2015 Following treatment with simvastatin, the alkaline phosphatase activity, and mRNA expression levels of osteocalcin and bone sialoprotein were increased significantly in the BMSCs. Simvastatin 25-36 bone gamma-carboxyglutamate protein Homo sapiens 103-114 24555011-8 2013 The relative expression and secretion of osteocalcin was significantly increased by cells cultured on scaffolds with 10 microM simvastatin when compared to scaffolds without simvastatin after 21 days. Simvastatin 174-185 bone gamma-carboxyglutamate protein Homo sapiens 41-52 22341085-7 2012 The simvastatin and Emdogain groups increased the odontogenic potential of the BPC group with respect to ALP activity, mineralization nodules, messenger RNA expression of ALP, osteopontin, osteocalcin, Runx2, and osterix. Simvastatin 4-15 bone gamma-carboxyglutamate protein Homo sapiens 189-200 24471035-6 2013 Expression of osteocalcin mRNA was observed after three days in the 1.0 microM simvastatin-treated group. Simvastatin 79-90 bone gamma-carboxyglutamate protein Homo sapiens 14-25 22399266-9 2012 Simvastatin induced a dose-dependent increase in OC mRNA expression of AOBs and did not influence that in PDLs. Simvastatin 0-11 bone gamma-carboxyglutamate protein Homo sapiens 49-51 23214015-5 2012 Simvastatin therapy led to normalization of osteocalcin level (p<0.01) within 6 months. Simvastatin 0-11 bone gamma-carboxyglutamate protein Homo sapiens 44-55 17252541-6 2007 A significant increase in COL1A1, osteocalcin, and BMP2 gene expression was detected when hOB cultures were treated with simvastatin or atorvastatin at different concentrations. Simvastatin 121-132 bone gamma-carboxyglutamate protein Homo sapiens 34-45 20381859-3 2010 We found 0.01 microm, 0.1 microm, and 1 microm simvastatin could induce hADSCs" osteoblastic differentiation in vitro that accompanied with non-inhibition on cell proliferation, high alkaline phosphatase activity, more mineralization deposition and more expression of osteoblast-related genes such as osteocalcin, core binding factor alpha1, bone morphogenetic protein-2, vascular endothelial growth factor, and basic fibroblast growth factor. Simvastatin 47-58 bone gamma-carboxyglutamate protein Homo sapiens 301-312 20381859-4 2010 Simvastatin at 1 mum seemed the most optimal concentration due to its high osteocalcin secretion in media (P < 0.01). Simvastatin 0-11 bone gamma-carboxyglutamate protein Homo sapiens 75-86 19249597-5 2009 Quantitative RT-PCR revealed both osteocalcin and dentin sialophosphoprotein to be significantly up-regulated when DPSCs were cultured with simvastatin in comparison to bone morphogenetic protein-2 treatment. Simvastatin 140-151 bone gamma-carboxyglutamate protein Homo sapiens 34-45 21431270-4 2010 RESULTS: 10-9mol/L and 10-8mol/L concentrations of simvastatin slightly promoted MG63 cell proliferation; 10-7mol/L and 10-6mol/L concentrations of simvastatin greatly enhanced the OPG and OC mRNA expression; All concentrations of simvastatin had an inhibitory effect on MG63 cell migration. Simvastatin 51-62 bone gamma-carboxyglutamate protein Homo sapiens 189-191 21431270-4 2010 RESULTS: 10-9mol/L and 10-8mol/L concentrations of simvastatin slightly promoted MG63 cell proliferation; 10-7mol/L and 10-6mol/L concentrations of simvastatin greatly enhanced the OPG and OC mRNA expression; All concentrations of simvastatin had an inhibitory effect on MG63 cell migration. Simvastatin 148-159 bone gamma-carboxyglutamate protein Homo sapiens 189-191 21431270-4 2010 RESULTS: 10-9mol/L and 10-8mol/L concentrations of simvastatin slightly promoted MG63 cell proliferation; 10-7mol/L and 10-6mol/L concentrations of simvastatin greatly enhanced the OPG and OC mRNA expression; All concentrations of simvastatin had an inhibitory effect on MG63 cell migration. Simvastatin 148-159 bone gamma-carboxyglutamate protein Homo sapiens 189-191