PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22022327-8	2011	On day 5, gene expressions of ET-1, ERA, NOS2, NOS3, MMP and TIMP significantly decreased in the simvastatin group.	Simvastatin	97-108	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	61-65	
31410004-0	2019	Simvastatin pretreatment ameliorates t-PA-induced hemorrhage transformation and MMP-9/TIMP-1 imbalance in thromboembolic cerebral ischemic rats.	Simvastatin	0-11	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	86-92	
31410004-2	2019	In this study, we investigated the effects of simvastatin pretreatment on t-PA-induced MMP-9/tissue inhibitor of metalloproteinase-1 (TIMP-1) imbalance and HT aggravation in a rat AIS model.	Simvastatin	46-57	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	87-132	
31410004-2	2019	In this study, we investigated the effects of simvastatin pretreatment on t-PA-induced MMP-9/tissue inhibitor of metalloproteinase-1 (TIMP-1) imbalance and HT aggravation in a rat AIS model.	Simvastatin	46-57	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	134-140	
31410004-7	2019	Results: The results suggested that pretreatment with simvastatin suppressed the increase in t-PA-induced MMP-9 levels and neutralized the elevated MMP-9/TIMP-1 ratio, but had no effect on TIMP-1 levels.	Simvastatin	54-65	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	154-160	
31410004-11	2019	Conclusion: In this study, we showed that simvastatin pretreatment ameliorated t-PA-induced HT and MMP-9/TIMP-1 imbalance, and demonstrated that the RhoA/ROCK pathway was implicated.	Simvastatin	42-53	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	105-111