PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24419251-5 2014 RESULTS: The IL-17A, IL-6, IL-22 and IFN-gamma were significantly reduced in a dose response after simvastatin treatment (50 muM, p = 0.0005; p < 0.0001; p < 0.02; p = 0.0005, respectively). Simvastatin 99-110 interleukin 22 Homo sapiens 27-32 24419251-7 2014 The results also showed that only RA patients with severe disease (DAS28 >5.1 and CDAI >22) had poor response to simvastatin in reducing cytokines levels, mainly for IL-17A and IL-22 cytokines (p = 0.03; p = 0.039, respectively). Simvastatin 119-130 interleukin 22 Homo sapiens 183-188 21856936-4 2011 We report that simvastatin, one of the most hydrophobic statins with good CNS penetration, inhibited Th17 cell differentiation and IL-17A, IL-17F, IL-21, and IL-22 secretion in in vitro-differentiated naive CD4(+) T cells from RR MS patients. Simvastatin 15-26 interleukin 22 Homo sapiens 158-163