PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24244596-10 2013 Simvastatin prevented high glucose or hyperglycemia-induced dysregulation of occludin and ZO-1 by inhibition of RhoA/ROCK1 signaling in cultured GEnCs and in db/db mice with early-stage DN. Simvastatin 0-11 occludin Mus musculus 77-85 24244596-11 2013 CONCLUSION: Our results indicate that activation of RhoA/ROCK1 by high glucose disrupts the expression and translocation of occludin/ZO-1 and that simvastatin alleviates occludin/ZO-1 dysregulation and albuminuria by suppressing RhoA/ROCK1 signaling during early-stage DN. Simvastatin 147-158 occludin Mus musculus 170-178