PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19358180-0 2009 Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta1-mediated activation of intestinal fibroblasts. Simvastatin 0-11 SMAD family member 3 Homo sapiens 20-26 23817018-10 2013 RESULTS: Sim significantly attenuated the TGF-beta1-induced decrease in E-Cad levels and elevated the levels of alpha-SMA, Vi and FN via the suppression of Smad2 and Smad3 phosphorylation. Simvastatin 9-12 SMAD family member 3 Homo sapiens 166-171 30220377-4 2018 We aimed to assess whether simvastatin-mediated reduction in TGF-beta1-augmented profibrotic response involves reduction in phospho-SMAD2/3 owing to activation of protein-phosphatase in hVFs. Simvastatin 27-38 SMAD family member 3 Homo sapiens 132-139 24471776-11 2014 The TGF-beta1-induced Smad2 and Smad3 phosphorylation levels were abrogated by simvastatin pretreatment. Simvastatin 79-90 SMAD family member 3 Homo sapiens 32-37 19358180-11 2009 Simvastatin pretreatment inhibited TGF-beta1-mediated phosphorylation of smad-3. Simvastatin 0-11 SMAD family member 3 Homo sapiens 73-79 19358180-12 2009 CONCLUSION: Simvastatin abrogates TGF-beta1-mediated intestinal fibroblast activation by inhibition of smad-3 phosphorylation. Simvastatin 12-23 SMAD family member 3 Homo sapiens 103-109