PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24307429-7 2014 Apart from significantly reducing plasma total cholesterol and LDL, simvastatin also reduced serum levels of fetuin-A (by ~62.6 %), OPG (by ~47.2 %), OPN (by ~44.6 %) and hsCRP (by ~45.3 %) (p < 0.05) in SG patients. Simvastatin 68-79 TNF receptor superfamily member 11b Homo sapiens 132-135 24555750-5 2014 Serum OPG concentrations were significantly higher in the simvastatin-treated patients with hyperlipidemia than in the diet-treated patients with hyperlipidemia (P = 0.05). Simvastatin 58-69 TNF receptor superfamily member 11b Homo sapiens 6-9 24555750-7 2014 CONCLUSIONS: Within the limits of this study, the findings suggest that the intake of simvastatin is associated with increasing serum OPG concentrations, and this could have a protective effect against bone breakdown and periodontal attachment loss. Simvastatin 86-97 TNF receptor superfamily member 11b Homo sapiens 134-137 24307429-10 2014 Simvastatin treatment for 6 months significantly decreased serum fetuin-A, OPG and OPN levels, but the clinical relevance of this requires further investigation. Simvastatin 0-11 TNF receptor superfamily member 11b Homo sapiens 75-78 17804683-0 2007 Simvastatin reduces plasma osteoprotegerin in type 2 diabetic patients with microalbuminuria. Simvastatin 0-11 TNF receptor superfamily member 11b Homo sapiens 27-42 22399266-11 2012 Finally, the expression of OPG in AOBs and PDLs was stimulated by 1-10 and 100 nM simvastatin, respectively. Simvastatin 82-93 TNF receptor superfamily member 11b Homo sapiens 27-30 21431270-4 2010 RESULTS: 10-9mol/L and 10-8mol/L concentrations of simvastatin slightly promoted MG63 cell proliferation; 10-7mol/L and 10-6mol/L concentrations of simvastatin greatly enhanced the OPG and OC mRNA expression; All concentrations of simvastatin had an inhibitory effect on MG63 cell migration. Simvastatin 51-62 TNF receptor superfamily member 11b Homo sapiens 181-184 21431270-4 2010 RESULTS: 10-9mol/L and 10-8mol/L concentrations of simvastatin slightly promoted MG63 cell proliferation; 10-7mol/L and 10-6mol/L concentrations of simvastatin greatly enhanced the OPG and OC mRNA expression; All concentrations of simvastatin had an inhibitory effect on MG63 cell migration. Simvastatin 148-159 TNF receptor superfamily member 11b Homo sapiens 181-184 21431270-4 2010 RESULTS: 10-9mol/L and 10-8mol/L concentrations of simvastatin slightly promoted MG63 cell proliferation; 10-7mol/L and 10-6mol/L concentrations of simvastatin greatly enhanced the OPG and OC mRNA expression; All concentrations of simvastatin had an inhibitory effect on MG63 cell migration. Simvastatin 148-159 TNF receptor superfamily member 11b Homo sapiens 181-184 31971101-8 2021 Considering that the statins-induced modulation of OPG is central to the statins-driven osteoprotective signalling, statins could be suggested as illustration of the role of OPG in the bone/vessels crosstalk, if further studies consolidate the contribution of OPG to the cardioprotective role of statins. Simvastatin 21-28 TNF receptor superfamily member 11b Homo sapiens 51-54 31971101-8 2021 Considering that the statins-induced modulation of OPG is central to the statins-driven osteoprotective signalling, statins could be suggested as illustration of the role of OPG in the bone/vessels crosstalk, if further studies consolidate the contribution of OPG to the cardioprotective role of statins. Simvastatin 21-28 TNF receptor superfamily member 11b Homo sapiens 174-177 31971101-8 2021 Considering that the statins-induced modulation of OPG is central to the statins-driven osteoprotective signalling, statins could be suggested as illustration of the role of OPG in the bone/vessels crosstalk, if further studies consolidate the contribution of OPG to the cardioprotective role of statins. Simvastatin 21-28 TNF receptor superfamily member 11b Homo sapiens 174-177 31971101-8 2021 Considering that the statins-induced modulation of OPG is central to the statins-driven osteoprotective signalling, statins could be suggested as illustration of the role of OPG in the bone/vessels crosstalk, if further studies consolidate the contribution of OPG to the cardioprotective role of statins. Simvastatin 73-80 TNF receptor superfamily member 11b Homo sapiens 51-54 31971101-8 2021 Considering that the statins-induced modulation of OPG is central to the statins-driven osteoprotective signalling, statins could be suggested as illustration of the role of OPG in the bone/vessels crosstalk, if further studies consolidate the contribution of OPG to the cardioprotective role of statins. Simvastatin 73-80 TNF receptor superfamily member 11b Homo sapiens 51-54 31971101-8 2021 Considering that the statins-induced modulation of OPG is central to the statins-driven osteoprotective signalling, statins could be suggested as illustration of the role of OPG in the bone/vessels crosstalk, if further studies consolidate the contribution of OPG to the cardioprotective role of statins. Simvastatin 73-80 TNF receptor superfamily member 11b Homo sapiens 51-54