PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18463201-5	2008	Simvastatin potentiated the effect of doxorubicin on the NF-kappaB pathway and the inducible NO synthase expression.	Simvastatin	0-11	nitric oxide synthase 2	Homo sapiens	83-104	
28214453-11	2017	Simvastatin decreased iNOS, HO-1, HIF-1alpha and CSE whilst it increased eNOS phosphorylation.	Simvastatin	0-11	nitric oxide synthase 2	Homo sapiens	22-26	
31734364-9	2020	However, endocan and simvastatin combination treatment could suppress NO, ROS production and iNOS, CRP activation.	Simvastatin	21-32	nitric oxide synthase 2	Homo sapiens	93-97	
24098525-10	2013	Simvastatin inhibited LX-2 cells activation due to TGF-beta1 or L-NAME by increasing the expression of eNOS and decreasing the expression of iNOS.	Simvastatin	0-11	nitric oxide synthase 2	Homo sapiens	141-145	
21925249-5	2011	Moreover, simvastatin significantly inhibited LPS-induced inducible nitric oxide synthase (NOS) expression, and formation of pro-inflammatory mediators, including tumor necrosis factor-alpha (TNF-alpha), nitrite and free radicals, but enhanced interleukin-10 (IL-10) production.	Simvastatin	10-21	nitric oxide synthase 2	Homo sapiens	68-89	
19729986-4	2009	Furthermore, nitric oxide (NO) content and inducible NO synthase (iNOS) mRNA expression were significantly higher in the simvastatin-treated group than in the corresponding control group.	Simvastatin	121-132	nitric oxide synthase 2	Homo sapiens	43-64	
19729986-4	2009	Furthermore, nitric oxide (NO) content and inducible NO synthase (iNOS) mRNA expression were significantly higher in the simvastatin-treated group than in the corresponding control group.	Simvastatin	121-132	nitric oxide synthase 2	Homo sapiens	66-70	
19729986-5	2009	The elevated ROS level and intracellular calcium concentration, enhanced mRNA expression of iNOS and total NO content might be responsible for the apoptotic and anti-proliferative effects of simvastatin in K562 cells.	Simvastatin	191-202	nitric oxide synthase 2	Homo sapiens	92-96	
11711492-7	2001	Similarly, simvastatin and lovastatin (34 micromol/L) caused robust upregulation of the iNOS protein level.	Simvastatin	11-22	nitric oxide synthase 2	Homo sapiens	88-92	
17671209-10	2007	Both fluvastatin and simvastatin increased iNOS mRNA and protein expression.	Simvastatin	21-32	nitric oxide synthase 2	Homo sapiens	43-47