PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27478339-12 2016 Connective tissue growth factor (CTGF) and transforming growth factor (TGF)-beta1 gene expression decreased significantly in the simvastatin group compared to the control group (P < 0.001). Simvastatin 129-140 cellular communication network factor 2 Rattus norvegicus 0-31 27478339-12 2016 Connective tissue growth factor (CTGF) and transforming growth factor (TGF)-beta1 gene expression decreased significantly in the simvastatin group compared to the control group (P < 0.001). Simvastatin 129-140 cellular communication network factor 2 Rattus norvegicus 33-37 23980058-17 2013 Treatment with either metformin or simvastatin attenuated the fibrosis progression induced by DHEA exposure, as evidenced by a reduction of TGF-beta, plus CTGF or not, in both ovarian and uterine tissues. Simvastatin 35-46 cellular communication network factor 2 Rattus norvegicus 155-159 22932337-0 2012 [Effects of simvastatin on expression of connective tissue growth factor in vitreous and retina of diabetic rats]. Simvastatin 12-23 cellular communication network factor 2 Rattus norvegicus 41-72 22932337-1 2012 OBJECTIVE: To study the effects of simvastatin on the expression of connective tissue growth factor (CTGF) that cause fibrosis in the vitreous and retina after intravitreal injection in diabetic rats, and to explore the safety of this procedure. Simvastatin 35-46 cellular communication network factor 2 Rattus norvegicus 68-99 22932337-1 2012 OBJECTIVE: To study the effects of simvastatin on the expression of connective tissue growth factor (CTGF) that cause fibrosis in the vitreous and retina after intravitreal injection in diabetic rats, and to explore the safety of this procedure. Simvastatin 35-46 cellular communication network factor 2 Rattus norvegicus 101-105 22932337-11 2012 Concentrations of CTGF in vitreous of simvastatin intervention group, diabetes positive control group and normal control group rats were 359.21 microg/L, 478.47 microg/L and 210.78 microg/L, respectively (F = 252.366, P < 0.05). Simvastatin 38-49 cellular communication network factor 2 Rattus norvegicus 18-22 22932337-12 2012 The levels of CTGF in the vitreous of simvastatin intervention group and diabetic positive control group was significantly higher than that of the normal control group and showed significant difference (t = 12.123, 23.816;P < 0.05). Simvastatin 38-49 cellular communication network factor 2 Rattus norvegicus 14-18 22932337-13 2012 CTGF levels in simvastatin intervention group were significantly lower than those in diabetic positive control group, and the difference was statistically significant. Simvastatin 15-26 cellular communication network factor 2 Rattus norvegicus 0-4 22932337-16 2012 Retinal expression of CTGF in simvastatin intervention group and diabetic positive control group were (26.60 +- 2.95)% and (42.31 +- 2.59)%, respectively. Simvastatin 30-41 cellular communication network factor 2 Rattus norvegicus 22-26 22932337-17 2012 Retinal expression of CTGF in simvastatin intervention group was reduced as compared to the diabetic positive control group, the difference was statistically significant (t = 12.112, P < 0.05). Simvastatin 30-41 cellular communication network factor 2 Rattus norvegicus 22-26 22932337-22 2012 CONCLUSIONS: Simvastatin could inhibit the expression of CTGF in the vitreous body and retina in diabetic rats. Simvastatin 13-24 cellular communication network factor 2 Rattus norvegicus 57-61 20936727-0 2010 [Effects of simvastatin on expression of CTGF and alpha-SMA in renal tubulointerstitium of rats with diabetic nephropathy]. Simvastatin 12-23 cellular communication network factor 2 Rattus norvegicus 41-45 20936727-1 2010 OBJECTIVE: To investigate the effects of low-dose simvastatin on the expression of connective tissue growth factor (CTGF) and alpha-smooth muscle actin (alpha-SMA) in the renal tubulointerstitium of rats with diabetic nephropathy. Simvastatin 50-61 cellular communication network factor 2 Rattus norvegicus 83-114 20936727-1 2010 OBJECTIVE: To investigate the effects of low-dose simvastatin on the expression of connective tissue growth factor (CTGF) and alpha-smooth muscle actin (alpha-SMA) in the renal tubulointerstitium of rats with diabetic nephropathy. Simvastatin 50-61 cellular communication network factor 2 Rattus norvegicus 116-120 20936727-8 2010 CONCLUSION: Simvastatin with a under cholesterol-lowering dose, can decrease the expression levels of CTGF and alpha-SMA in renal tubulointerstitium of rats with diabetic nephropathy, by which the progression of the tubulointerstitial fibrosis would be delayed. Simvastatin 12-23 cellular communication network factor 2 Rattus norvegicus 102-106 20117462-6 2010 In neonatal rat cardiomyocytes and fibroblasts, a specific small molecule inhibitor of Rac1 or simvastatin completely prevented the angiotensin II-induced up-regulation of CTGF, Cx43, and N-cadherin expression. Simvastatin 95-106 cellular communication network factor 2 Rattus norvegicus 172-176 17592071-4 2007 In cultured vascular smooth muscle cells (VSMCs) atorvastatin and simvastatin inhibited Ang II-induced CTGF production. Simvastatin 66-77 cellular communication network factor 2 Rattus norvegicus 103-107 19099753-0 2008 [Expression of connective tissue growth factor and its down-regulation by simvastatin administration in pulmonary hypertensive rats]. Simvastatin 74-85 cellular communication network factor 2 Rattus norvegicus 15-46 19099753-1 2008 OBJECTIVE: To explore the role of expression of connective tissue growth factor (CTGF) in pulmonary vascular remodeling of pulmonary hypertensive rats, and investigate the regulation of CTGF expression by simvastatin in this animal model. Simvastatin 205-216 cellular communication network factor 2 Rattus norvegicus 186-190 19099753-10 2008 The up-regulation of ET-1 and CTGF gene expression, and elevated synthesis of hydroxyproline were reversed in rats intervened with simvastatin. Simvastatin 131-142 cellular communication network factor 2 Rattus norvegicus 30-34 19099753-13 2008 Simvastatin can prevent and, to some extent, reverse the vascular remodeling via down-regulation of CTGF gene expression. Simvastatin 0-11 cellular communication network factor 2 Rattus norvegicus 100-104