PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33774267-0	2021	Simvastatin mitigates depressive-like behavior in ovariectomized rats: Possible role of NLRP3 inflammasome and estrogen receptors" modulation.	Simvastatin	0-11	NLR family, pyrin domain containing 3	Rattus norvegicus	88-93	
32242391-10	2020	Both simvastatin and Sini powder significantly ameliorated the NAFLD pathology and the abnormal expression of NF-kappaB, NLRP3, ASC, caspase-1, IL-1beta, and IL-6 (all P < 0.01).	Simvastatin	5-16	NLR family, pyrin domain containing 3	Rattus norvegicus	121-126	
29207644-0	2017	Protection by simvastatin on hyperglycemia-induced endothelial dysfunction through inhibiting NLRP3 inflammasomes.	Simvastatin	14-25	NLR family, pyrin domain containing 3	Rattus norvegicus	94-99	
29207644-4	2017	Here, we explored the role and mechanisms of simvastatin in the activation of NLRP3 inflammasome which are involved in vascular endothelial hyperpermeability causing by the disruption of tight junction protein ZO-1 and adherens junction protein VE-Cadherin, an early initiation of cardiovascular complication.	Simvastatin	45-56	NLR family, pyrin domain containing 3	Rattus norvegicus	78-83	
29207644-6	2017	Simvastatin treatment remarkably abolished vascular endothelial hyperpermeability and enhanced the protein expression of ZO-1 and VE-Cadherin through NLRP3 inflammasome.	Simvastatin	0-11	NLR family, pyrin domain containing 3	Rattus norvegicus	150-155	
29207644-7	2017	Mechanistically, the inhibitory role of simvastatin endothelial hyperpermeability is attributed to the decreased release of cytoplasmic high mobility group box protein-1 (HMGB1) derived from endothelial NLRP3 inflammasome activation.	Simvastatin	40-51	NLR family, pyrin domain containing 3	Rattus norvegicus	203-208	
29207644-9	2017	Collectively, the mechanism of simvastatin treatment alleviating vascular endothelial permeability dysfunction may be through inhibiting the NLRP3 inflammasome-dependent HMGB1 release in RAECs.	Simvastatin	31-42	NLR family, pyrin domain containing 3	Rattus norvegicus	141-146