PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23062767-10	2012	Three months of treatment with either simvastatin or its combination with ezetimibe resulted in a significant reduction of TLR2 and TLR4 expression (p < 0.01 compared with baseline values) with no intergroup differences.	Simvastatin	38-49	toll like receptor 2	Homo sapiens	123-127	
28711708-9	2017	There was a suppression of TLR-2 and TLR-4 expression by 21 +- 8% and 18 +- 7%, respectively, compared to 0-h baseline, after cream intake following ezetimibe and simvastatin combination treatment.	Simvastatin	163-174	toll like receptor 2	Homo sapiens	27-32	
23062767-12	2012	CONCLUSIONS: A high simvastatin dose or the combination of a low-dose simvastatin with ezetimibe reduce to a similar extent TLR2, TLR4 membrane expression and LPS-induced IL-6 and IL-1beta production in monocytes of hypercholesterolemic patients.	Simvastatin	20-31	toll like receptor 2	Homo sapiens	124-128	
23062767-12	2012	CONCLUSIONS: A high simvastatin dose or the combination of a low-dose simvastatin with ezetimibe reduce to a similar extent TLR2, TLR4 membrane expression and LPS-induced IL-6 and IL-1beta production in monocytes of hypercholesterolemic patients.	Simvastatin	70-81	toll like receptor 2	Homo sapiens	124-128	
20473500-1	2011	To investigate whether anti-inflammatory effects of HMG-CoA reductase inhibitor simvastatin (SMV) in rheumatoid arthritis (RA) is mediated by Toll-like receptor-2 (TLR-2) signal via inhibiting activation of RhoA, a small Rho GTPase that plays an important role in inflammatory responses.	Simvastatin	93-96	toll like receptor 2	Homo sapiens	142-162	
20473500-1	2011	To investigate whether anti-inflammatory effects of HMG-CoA reductase inhibitor simvastatin (SMV) in rheumatoid arthritis (RA) is mediated by Toll-like receptor-2 (TLR-2) signal via inhibiting activation of RhoA, a small Rho GTPase that plays an important role in inflammatory responses.	Simvastatin	80-91	toll like receptor 2	Homo sapiens	142-162	
20473500-1	2011	To investigate whether anti-inflammatory effects of HMG-CoA reductase inhibitor simvastatin (SMV) in rheumatoid arthritis (RA) is mediated by Toll-like receptor-2 (TLR-2) signal via inhibiting activation of RhoA, a small Rho GTPase that plays an important role in inflammatory responses.	Simvastatin	80-91	toll like receptor 2	Homo sapiens	164-169	
20473500-1	2011	To investigate whether anti-inflammatory effects of HMG-CoA reductase inhibitor simvastatin (SMV) in rheumatoid arthritis (RA) is mediated by Toll-like receptor-2 (TLR-2) signal via inhibiting activation of RhoA, a small Rho GTPase that plays an important role in inflammatory responses.	Simvastatin	93-96	toll like receptor 2	Homo sapiens	164-169	
16443229-7	2006	In conclusion, high-dose simvastatin pretreatment blunted TLR4 and TLR2 expression on monocytes in a human endotoxemia model on a posttranscriptional level.	Simvastatin	25-36	toll like receptor 2	Homo sapiens	67-71	
31221720-0	2019	Cross-linking Proteomics Indicates Effects of Simvastatin on the TLR2 Interactome and Reveals ACTR1A as a Novel Regulator of the TLR2 Signal Cascade.	Simvastatin	46-57	toll like receptor 2	Homo sapiens	65-69	
31221720-6	2019	A hemagglutinin (HA)-tagged-TLR2 transfected HEK293 cell line was used to precipitate the TLR2 interactome upon cell exposure to the TLR2 agonist Pam3CSK4 and simvastatin, singly and in combination.	Simvastatin	159-170	toll like receptor 2	Homo sapiens	28-32	
31221720-6	2019	A hemagglutinin (HA)-tagged-TLR2 transfected HEK293 cell line was used to precipitate the TLR2 interactome upon cell exposure to the TLR2 agonist Pam3CSK4 and simvastatin, singly and in combination.	Simvastatin	159-170	toll like receptor 2	Homo sapiens	90-94	
31221720-6	2019	A hemagglutinin (HA)-tagged-TLR2 transfected HEK293 cell line was used to precipitate the TLR2 interactome upon cell exposure to the TLR2 agonist Pam3CSK4 and simvastatin, singly and in combination.	Simvastatin	159-170	toll like receptor 2	Homo sapiens	90-94	
31221720-8	2019	Proteomic analysis revealed important combinatorial effects of simvastatin and Pam3CSK4 on the TLR2 interactome.	Simvastatin	63-74	toll like receptor 2	Homo sapiens	95-99