PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32418888-5 2020 We discovered that PCCs secrete CCL3 and stimulate IL-6, CCL2, ICAM-1 and VCAM-1 expression in MSCs and that the MSC-PCC crosstalk can be disrupted by the lipid-lowering drug simvastatin, which displays pleiotropic effects on cell metabolism and suppresses IL-6 and CCL2 production by MSCs and CCL3 secretion by PCCs. Simvastatin 175-186 vascular cell adhesion molecule 1 Homo sapiens 74-80 29175057-6 2018 Simvastatin blocks soluble SSAO/VAP-1 release and prevents E-selectin and VCAM-1 overexpression as well. Simvastatin 0-11 vascular cell adhesion molecule 1 Homo sapiens 74-80 22245985-0 2012 Simvastatin reduces VCAM-1 expression in human umbilical vein endothelial cells exposed to lipopolysaccharide. Simvastatin 0-11 vascular cell adhesion molecule 1 Homo sapiens 20-26 28161429-0 2017 mZD7349 peptide-conjugated PLGA nanoparticles directed against VCAM-1 for targeted delivery of simvastatin to restore dysfunctional HUVECs. Simvastatin 95-106 vascular cell adhesion molecule 1 Homo sapiens 63-69 27003335-8 2017 Treatment with simvastatin significantly attenuated LPS-stimulated production of IL-1beta, IL-6, VCAM-1 and ICAM-1 (P < 0.05). Simvastatin 15-26 vascular cell adhesion molecule 1 Homo sapiens 97-103 25978361-13 2015 Indeed, 5 muM simvastatin as well as 20 muM benznidazole prevented the increase in E-selectin, ICAM-1 and VCAM-1 expression in T. cruzi-infected endothelial cells by decreasing the NF-kappaB pathway. Simvastatin 14-25 vascular cell adhesion molecule 1 Homo sapiens 106-112 25213768-9 2014 Simvastatin treatment also decreased the expression of the vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 proteins, as measured in homogenized lung tissues (P<0.05) and human epithelial cells. Simvastatin 0-11 vascular cell adhesion molecule 1 Homo sapiens 59-130 22245985-5 2012 RESULTS: VCAM-1 mRNA appeared to be the only target that was affected by the statins, with its expression being partially and almost completely reduced by simvastatin at 50 and 125 muM concentrations, respectively, and only partially reduced by atorvastatin, but not reduced by rosuvastatin. Simvastatin 155-166 vascular cell adhesion molecule 1 Homo sapiens 9-15 22245985-6 2012 VCAM-1 protein production was inhibited by simvastatin at concentrations from 5 to 125 muM. Simvastatin 43-54 vascular cell adhesion molecule 1 Homo sapiens 0-6 22245985-8 2012 CONCLUSIONS: This study showed that simvastatin reduces VCAM-1 expression in HUVECs exposed to LPS and decreases leukocyte-endothelial cell adhesion. Simvastatin 36-47 vascular cell adhesion molecule 1 Homo sapiens 56-62 22298164-0 2012 Simvastatin and atorvastatin attenuate VCAM-1 and uPAR expression on human endothelial cells and platelet surface expression of CD40 ligand. Simvastatin 0-11 vascular cell adhesion molecule 1 Homo sapiens 39-45 22405819-11 2012 The strong inductive effect of TNF-alpha on VCAM-1 was counteracted by simvastatin and shear stress in an additive dose-response dependent way. Simvastatin 71-82 vascular cell adhesion molecule 1 Homo sapiens 44-50 22298164-7 2012 The increased expression of VCAM-1 and uPAR on endothelial cells by stimulation with LPS and by direct contact with activated platelets was significantly reduced to a similar extent through pre-incubation with both atorvastatin and simvastatin (p < 0.05). Simvastatin 232-243 vascular cell adhesion molecule 1 Homo sapiens 28-34 21797102-11 2011 The results of the study demonstrated that simvastatin in a dose of 80 mg exerted an effect on the levels of some CAM, and particularly on VCAM-1 in contrast to the same drug used in a dose of 40 mg. Simvastatin 43-54 vascular cell adhesion molecule 1 Homo sapiens 139-145 21874229-0 2011 Simvastatin reduces tumor cell adhesion to human peritoneal mesothelial cells by decreased expression of VCAM-1 and beta1 integrin. Simvastatin 0-11 vascular cell adhesion molecule 1 Homo sapiens 105-111 21874229-9 2011 Expression of the adhesion molecules VCAM-1, ICAM-1 and beta1 integrin chain under the influence of simvastatin 0.1-100 microM for 24-72 h was analyzed using flow cytometry. Simvastatin 100-111 vascular cell adhesion molecule 1 Homo sapiens 37-43 21874229-11 2011 Concomitantly simvastatin decreased the expression of VCAM-1 on HMCs. Simvastatin 14-25 vascular cell adhesion molecule 1 Homo sapiens 54-60 21527854-9 2011 In addition, hsCRP and vascular cell adhesion protein-1 were both significantly lower after simvastatin therapy compared to controls (P <= 0.005 for both). Simvastatin 92-103 vascular cell adhesion molecule 1 Homo sapiens 23-55 21527854-14 2011 Although the observed improvements in reproductive function were mild, the reductions in hsCRP and vascular cell adhesion protein-1 after simvastatin treatment were significant, suggesting the need for further clinical trials to clarify simvastatin"s impact on reproductive physiology. Simvastatin 138-149 vascular cell adhesion molecule 1 Homo sapiens 99-131 21865358-9 2011 Both simvastatin and metformin improved menstrual cyclicity and decreased hirsutism, acne, ovarian volume, body mass index, C-reactive protein, and soluble vascular cell adhesion molecule-1. Simvastatin 5-16 vascular cell adhesion molecule 1 Homo sapiens 156-189 19481207-10 2009 Simvastatin (1 micromol/L) suppressed the non-uniform shear stress- and TNF-alpha-induced increase in monocytic cell adhesion by about 30% via inhibition of VCAM-1 expression. Simvastatin 0-11 vascular cell adhesion molecule 1 Homo sapiens 157-163 20863785-3 2010 In this study, the effect of simvastatin on vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression was evaluated in human abdominal aortic endothelial cells (HAAEC) conditioned with various levels of laminar wall shear stress with or without tumor necrosis factor alpha (TNFalpha). Simvastatin 29-40 vascular cell adhesion molecule 1 Homo sapiens 44-77 20863785-3 2010 In this study, the effect of simvastatin on vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression was evaluated in human abdominal aortic endothelial cells (HAAEC) conditioned with various levels of laminar wall shear stress with or without tumor necrosis factor alpha (TNFalpha). Simvastatin 29-40 vascular cell adhesion molecule 1 Homo sapiens 79-85 20863785-5 2010 In static culture, simvastatin potentiated the TNFalpha-induced increase in VCAM-1 and ICAM-1 mRNA but not total protein at 24 h. Mevalonate, a precursor to cholesterol biosynthesis, eliminated the effect of simvastatin. Simvastatin 19-30 vascular cell adhesion molecule 1 Homo sapiens 76-82 20863785-7 2010 A shear stress of 12.5 dyn/cm2 eliminated the increase in VCAM-1 by simvastatin, while 25 dyn/cm2 was needed for ICAM-1. Simvastatin 68-79 vascular cell adhesion molecule 1 Homo sapiens 58-64 20863785-8 2010 We conclude that simvastatin enhances VCAM-1 and ICAM-1 gene expression in TNFalpha-activated endothelial cells through inhibition of HMG-CoA reductase. Simvastatin 17-28 vascular cell adhesion molecule 1 Homo sapiens 38-44 20863785-9 2010 High levels of laminar shear stress prevented the upregulation of VCAM-1 and ICAM-1 by simvastatin suggesting that an induction of cell adhesion molecules by statins may not occur in endothelial cells exposed to shear stress from blood flow. Simvastatin 87-98 vascular cell adhesion molecule 1 Homo sapiens 66-72 19887846-3 2010 We further examined the effect of losartan and simvastatin on myoglobin-induced VCAM-1 expression and the signaling pathways. Simvastatin 47-58 vascular cell adhesion molecule 1 Homo sapiens 80-86 19887846-9 2010 Losartan and simvastatin suppressed myoglobin-induced VCAM-1 expression via inhibition of c-Src kinase. Simvastatin 13-24 vascular cell adhesion molecule 1 Homo sapiens 54-60 18192240-5 2008 Simvastatin treatment lead to downregulation of many pro-inflammatory genes including several chemokines [e.g. monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory proteins-1alpha and beta, interleukin-2 receptor-beta], members of the tumour necrosis factor family (e.g. lymphotoxin beta), vascular cell adhesion molecule-1, and tissue factor (TF). Simvastatin 0-11 vascular cell adhesion molecule 1 Homo sapiens 301-334 18269829-0 2007 [Simvastatin downregulates CD40L induced vascular cell adhesion molecule-1 expression and adhesive function in human umbilical vein endothelial cells]. Simvastatin 1-12 vascular cell adhesion molecule 1 Homo sapiens 41-74 18226044-13 2008 Simvastatin or pravastatin significantly reduced HCY-induced VCAM-1 expression and endothelial adhesiveness to MNCs from CAD patients. Simvastatin 0-11 vascular cell adhesion molecule 1 Homo sapiens 61-67 18057884-6 2008 Simvastatin also decreased CRP-induced vascular cell adhesion molecule-1 expression and reduced monocyte adhesion on endothelial cells. Simvastatin 0-11 vascular cell adhesion molecule 1 Homo sapiens 39-72 17196684-10 2007 25 micromol/L simvastatin markedly suppressed the CRP effect on VCAM-1 and intercellular CAM-1 expressions of EC. Simvastatin 14-25 vascular cell adhesion molecule 1 Homo sapiens 64-70 18269829-1 2007 OBJECTIVE: To investigate the effects of simvastatin on vascular cell adhesion molecule-1 (VCAM-1) expression and adhesive function in ECV-304 cells treated with CD40L. Simvastatin 41-52 vascular cell adhesion molecule 1 Homo sapiens 56-89 18269829-1 2007 OBJECTIVE: To investigate the effects of simvastatin on vascular cell adhesion molecule-1 (VCAM-1) expression and adhesive function in ECV-304 cells treated with CD40L. Simvastatin 41-52 vascular cell adhesion molecule 1 Homo sapiens 91-97 18269829-4 2007 RESULTS: Simvastatin (0 - 10 micromol/L) decreased in a concentration-dependent manner the expression of VCAM-1 induced by CD40L and this effect could be blocked by cotreatment with mevalonic acid. Simvastatin 9-20 vascular cell adhesion molecule 1 Homo sapiens 105-111 18269829-6 2007 CONCLUSION: Simvastatin downregulates VCAM-1 expression and adhesive capacity of lymphocytes to endothelial cells induced by CD40L. Simvastatin 12-23 vascular cell adhesion molecule 1 Homo sapiens 38-44 16529752-4 2007 The aim of this study was the comparison of cerivastatin and simvastatin-mediated effects on inflammation-induced ICAM-1 and VCAM-1 expression in human umbilical venous endothelial cells (HUVEC). Simvastatin 61-72 vascular cell adhesion molecule 1 Homo sapiens 125-131 16529752-11 2007 We conclude that cerivastatin and simvastatin reduce TNF-alpha-induced up-regulation of ICAM-1 and VCAM-1 surface expression via increased protein shedding mediated by HMG-CoA reductase inhibition and subsequent isoprenoid depletion. Simvastatin 34-45 vascular cell adhesion molecule 1 Homo sapiens 99-105 15578471-4 2004 In this study, the effects of preoperative simvastatin treatment, at doses equivalent to those used orally for cholesterol control, were studied on plasma levels of VCAM-1, ICAM-1, and ELAM-1. Simvastatin 43-54 vascular cell adhesion molecule 1 Homo sapiens 165-171 16973154-7 2006 Unexpectedly, simvastatin increased adhesion molecules expression VCAM-1 and ICAM-1 on cytokine-stimulated endothelial cells. Simvastatin 14-25 vascular cell adhesion molecule 1 Homo sapiens 66-72 17261959-7 2007 The effect of CRP on VCAM-1 expression in HUVECs and supernatant levels of MCP-1 and IL-6 were significantly suppressed by 25 micromol/L simvastatin with stepwise increased suppression as simvastatin dose increased to 50, 75, and 100 micromol/L (all P < 0.0001). Simvastatin 137-148 vascular cell adhesion molecule 1 Homo sapiens 21-27 17261959-7 2007 The effect of CRP on VCAM-1 expression in HUVECs and supernatant levels of MCP-1 and IL-6 were significantly suppressed by 25 micromol/L simvastatin with stepwise increased suppression as simvastatin dose increased to 50, 75, and 100 micromol/L (all P < 0.0001). Simvastatin 188-199 vascular cell adhesion molecule 1 Homo sapiens 21-27 15234187-3 2004 We investigated the effect of simvastatin, an inhibitor of HMG-CoA reductase administered to reduce plasma levels of LDL-cholesterol, on the expression of vascular cell adhesion molecule-1 (VCAM-1) and intracellular cell adhesion molecule-1 (ICAM-1) by human umbilical vein endothelial cells (HUVEC) stimulated with tumor necrosis factor alpha (TNFalpha). Simvastatin 30-41 vascular cell adhesion molecule 1 Homo sapiens 155-188 15234187-3 2004 We investigated the effect of simvastatin, an inhibitor of HMG-CoA reductase administered to reduce plasma levels of LDL-cholesterol, on the expression of vascular cell adhesion molecule-1 (VCAM-1) and intracellular cell adhesion molecule-1 (ICAM-1) by human umbilical vein endothelial cells (HUVEC) stimulated with tumor necrosis factor alpha (TNFalpha). Simvastatin 30-41 vascular cell adhesion molecule 1 Homo sapiens 190-196 11947912-6 2002 Almost the same pattern was seen within both groups although the increase in VCAM-1 was only seen in the simvastatin group (P=0.017). Simvastatin 105-116 vascular cell adhesion molecule 1 Homo sapiens 77-83 15234187-5 2004 In TNFalpha-stimulated HUVEC, simvastatin decreased VCAM-1 and ICAM-1 mRNA levels, inhibited TNFalpha-induced activation of nuclear factor kappaB (NF-kappaB) and enhanced expression of peroxisome proliferator-activated receptor alpha (PPARalpha). Simvastatin 30-41 vascular cell adhesion molecule 1 Homo sapiens 52-58 14988255-12 2004 Long-term simvastatin treatment was accompanied by a lower increase in postprandial triglycerides, which was followed by smaller variations in ICAM-1, VCAM-1, E-selectin, and nitrotyrosine during the tests. Simvastatin 10-21 vascular cell adhesion molecule 1 Homo sapiens 151-157 14629460-7 2003 RESULTS: Pretreatment with simvastatin, fluvastatin or pravastatin potentiated the TNF-alpha and LPS-induced expression of E-selectin and VCAM-1, and mevalonate reversed the potentiating effect of these statins. Simvastatin 27-38 vascular cell adhesion molecule 1 Homo sapiens 138-144