PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30150424-1	2018	BACKGROUND/AIM: We have previously reported that simvastatin exhibits antioxidant properties via extracellular signal-regulated kinase (ERK)/cAMP-response element binding (CREB) protein-dependent induction of heme oxygenase-1 (HO1) and chronic nicotine exposure inhibits ERK/CREB signaling in renal proximal tubule cells (through p66shc).	Simvastatin	49-60	cAMP responsive element binding protein 1	Rattus norvegicus	172-176	
30150424-1	2018	BACKGROUND/AIM: We have previously reported that simvastatin exhibits antioxidant properties via extracellular signal-regulated kinase (ERK)/cAMP-response element binding (CREB) protein-dependent induction of heme oxygenase-1 (HO1) and chronic nicotine exposure inhibits ERK/CREB signaling in renal proximal tubule cells (through p66shc).	Simvastatin	49-60	cAMP responsive element binding protein 1	Rattus norvegicus	275-279	
30150424-6	2018	RESULTS: Nicotine suppressed simvastatin-dependent activation of HO1 and MnSOD promoters and activity of CREB and ELK1 via p66shc.	Simvastatin	29-40	cAMP responsive element binding protein 1	Rattus norvegicus	105-109	
30150424-7	2018	Overexpression of CREB or knockdown of p66shc restored simvastatin-dependent induction of HO1 and MnSOD in the presence of nicotine.	Simvastatin	55-66	cAMP responsive element binding protein 1	Rattus norvegicus	18-22	
26492285-0	2016	Simvastatin attenuates oleic acid-induced oxidative stress through CREB-dependent induction of heme oxygenase-1 in renal proximal tubule cells.	Simvastatin	0-11	cAMP responsive element binding protein 1	Rattus norvegicus	67-71	
19664625-7	2009	These data demonstrate that even a single prophylactic Sim administration protects from hypoxic ischemic brain damage and that neuroprotection is in part obtained by preserving Akt and stimulating CREB phosphorylation in neuronal cells.	Simvastatin	55-58	cAMP responsive element binding protein 1	Rattus norvegicus	197-201	
19664625-0	2009	Simvastatin acutely reduces ischemic brain damage in the immature rat via Akt and CREB activation.	Simvastatin	0-11	cAMP responsive element binding protein 1	Rattus norvegicus	82-86	
19664625-6	2009	Sim increased both Akt and CREB phosphorylation in neuronal cells and treatment with wortmannin completely blocked neuroprotection and p-Akt.	Simvastatin	0-3	cAMP responsive element binding protein 1	Rattus norvegicus	27-31	
17463319-11	2007	In summary, Ang II induced LCC alpha1C subunit expression via a protein kinase C-, reactive oxygen species-, and CREB-dependent pathway and was blocked by losartan and simvastatin.	Simvastatin	168-179	cAMP responsive element binding protein 1	Rattus norvegicus	113-117	
17463319-9	2007	Ang II (1 micromol/L, 2 hours) induced serine 133 phosphorylation of CREB and binding of CREB to CRE and increased LCC alpha1C subunit gene promoter activity through a protein kinase C/NADPH oxidase/reactive oxygen species pathway, which was blocked by the Ang II type 1 receptor blocker losartan and the antioxidant simvastatin.	Simvastatin	317-328	cAMP responsive element binding protein 1	Rattus norvegicus	69-73	
17463319-10	2007	In the rat model, Ang II infusion increased LCC alpha1C subunit expression and serine 133 phosphorylation of CREB, which were attenuated by oral losartan and simvastatin.	Simvastatin	158-169	cAMP responsive element binding protein 1	Rattus norvegicus	109-113