PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23543392-0 2013 Simvastatin reduces VEGF and NO levels in acute stages of experimental traumatic brain injury. Simvastatin 0-11 vascular endothelial growth factor A Rattus norvegicus 20-24 23543392-7 2013 In the T group, significant increases of VEGF levels in serum and brain tissues were noted, which were prevented with simvastatin treatment in the T + S group. Simvastatin 118-129 vascular endothelial growth factor A Rattus norvegicus 41-45 22683506-12 2012 Western blot and immunohistochemistry showed higher expression of BDNF and VEGF in the simvastatin treated group than the control group. Simvastatin 87-98 vascular endothelial growth factor A Rattus norvegicus 75-79 22683506-13 2012 In conclusion, simvastatin can help to repair spinal cord injury in rat, where the underlying mechanism appears to involve the mobilization of bone marrow stromal cells to the injured area and higher expression of BNDF and VEGF. Simvastatin 15-26 vascular endothelial growth factor A Rattus norvegicus 223-227 20821229-11 2011 Simvastatin treatment blocked hyperglycemia-induced increases in VEGF, angiopoietin 2 and erythropoietin levels, as demonstrated by RT-PCR and Western blot analysis. Simvastatin 0-11 vascular endothelial growth factor A Rattus norvegicus 65-69 23482588-8 2012 Simvastatin and atorvastatin treatment increased the expression of BDNF, VEGF and NGF in both low- and high-dose groups at 7 days after ICH (p < 0.05). Simvastatin 0-11 vascular endothelial growth factor A Rattus norvegicus 73-77 20821229-12 2011 CONCLUSIONS: Simvastatin treatment led to suppression of superoxide formation and decreased expression of VEGF, angiopoietin 2 and erythropoietin in diabetic rat retinas. Simvastatin 13-24 vascular endothelial growth factor A Rattus norvegicus 106-110 21211366-13 2010 CONCLUSIONS: simvastatin ameliorated the development of cigarette smoke-induced COPD in rats, partly by promoting alveolar epithelial cell proliferation and up-regulating the expression of VEGF. Simvastatin 13-24 vascular endothelial growth factor A Rattus norvegicus 189-193 20144589-7 2010 The use of insulin, combinations of insulin and pentoxifylline or simvastatin resulted in a significant decrease in gastric ulcer area, significant increase in epithelial regeneration assessed histologically, significant increase in gastric VEGF concentration, and gastric von Willebrand factor (vWF) as well as significant decrease in gastric TNF-alpha. Simvastatin 66-77 vascular endothelial growth factor A Rattus norvegicus 241-245 20566666-7 2010 RESULTS: Simvastatin significantly upregulated PGC-1alpha (P < 0.01), subsequently decreased Deltapsim (P < 0.05) and ROS generation (P < 0.01), inhibited PARP activation (P < 0.01), and further reduced VEGF expression (P < 0.01) and p38 MAPK activity (P < 0.01). Simvastatin 9-20 vascular endothelial growth factor A Rattus norvegicus 215-219 20144589-8 2010 A significant difference in gastric ulcer area as well as in gastric TNF-alpha, VEGF and vWF levels could be observed between rats that received combinations of insulin and pentoxifylline or simvastatin compared to rats that received either drug alone. Simvastatin 191-202 vascular endothelial growth factor A Rattus norvegicus 80-84 20159699-7 2010 Simvastatin treatment also significantly increased VEGF and NO levels and a positive correlation was noted between their levels. Simvastatin 0-11 vascular endothelial growth factor A Rattus norvegicus 51-55 20159699-9 2010 Simvastatin increases VEGF and NO and promotes neogenesis of the vasa vasorum for the benefit of the aortic function. Simvastatin 0-11 vascular endothelial growth factor A Rattus norvegicus 22-26 18563306-4 2009 Simvastatin treatment significantly increased the number of peripheral blood CD34+ CD133+ cells, and serum concentration of vascular endothelial growth factor (VEGF) and AKT was markedly increased in vivo. Simvastatin 0-11 vascular endothelial growth factor A Rattus norvegicus 124-158 18563306-4 2009 Simvastatin treatment significantly increased the number of peripheral blood CD34+ CD133+ cells, and serum concentration of vascular endothelial growth factor (VEGF) and AKT was markedly increased in vivo. Simvastatin 0-11 vascular endothelial growth factor A Rattus norvegicus 160-164 18563306-5 2009 In cultured EPC, simvastatin increased the concentrations of VEGF, AKT and eNOS. Simvastatin 17-28 vascular endothelial growth factor A Rattus norvegicus 61-65 18260796-0 2008 Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3K/Akt pathway, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injury. Simvastatin 0-11 vascular endothelial growth factor A Rattus norvegicus 37-41 20687301-1 2009 AIM: To determine the effect of local simvastatin application on the mRNA expression level of transforming growth factor-beta1 (TGF-beta1), bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) in the tooth sockets of rat. Simvastatin 38-49 vascular endothelial growth factor A Rattus norvegicus 181-215 33278579-7 2021 Moreover, qRT-PCR findings showed that the wounds treated with SMV alone had the highest expression levels of CD31, VEGF, Akt, mTOR, and p70S6K after 7 and 14 days of burn model (p < 0.001). Simvastatin 63-66 vascular endothelial growth factor A Rattus norvegicus 116-120 18569938-10 2008 Exogenous simvastatin and manumycin A treatment alleviated urinary albumin secretion and attenuated Ras activation and VEGF protein expression in the kidneys of diabetic rats. Simvastatin 10-21 vascular endothelial growth factor A Rattus norvegicus 119-123 18569938-12 2008 By inhibiting Ras activation, simvastatin modulates the high glucose-induced VEGF-mediated signaling pathway in vitro and in vivo. Simvastatin 30-41 vascular endothelial growth factor A Rattus norvegicus 77-81 12846751-12 2003 Overexpression of TGF beta 1 and VEGF was observed in the glomeruli of diabetic rats and was attenuated by losartan, simvastatin, or the combination of both to a similar level. Simvastatin 117-128 vascular endothelial growth factor A Rattus norvegicus 33-37 12535662-0 2003 Simvastatin stimulates VEGF release via p44/p42 MAP kinase in vascular smooth muscle cells. Simvastatin 0-11 vascular endothelial growth factor A Rattus norvegicus 23-27 12535662-2 2003 In the present study, we investigated the effect of simvastatin on vascular endothelial growth factor (VEGF) release, and the underlying mechanism, in a rat aortic smooth muscle cell line, A10 cells. Simvastatin 52-63 vascular endothelial growth factor A Rattus norvegicus 67-101 12535662-2 2003 In the present study, we investigated the effect of simvastatin on vascular endothelial growth factor (VEGF) release, and the underlying mechanism, in a rat aortic smooth muscle cell line, A10 cells. Simvastatin 52-63 vascular endothelial growth factor A Rattus norvegicus 103-107 12535662-3 2003 Administration of simvastatin increased the VEGF level in rat plasma in vivo. Simvastatin 18-29 vascular endothelial growth factor A Rattus norvegicus 44-48 12535662-4 2003 In cultured cells, simvastatin significantly stimulated VEGF release in a dose-dependent manner. Simvastatin 19-30 vascular endothelial growth factor A Rattus norvegicus 56-60 12535662-6 2003 PD98059 and U-0126, inhibitors of the upstream kinase that activates p44/p42 MAP kinase, significantly reduced the simvastatin-induced VEGF release in a dose-dependent manner. Simvastatin 115-126 vascular endothelial growth factor A Rattus norvegicus 135-139 12535662-8 2003 Moreover, a bolus injection of PD98059 truly suppressed the simvastatin-increased VEGF level in rat plasma in vivo. Simvastatin 60-71 vascular endothelial growth factor A Rattus norvegicus 82-86 12535662-9 2003 These results strongly suggest that p44/p42 MAP kinase plays a role at least partly in the simvastatin-stimulated VEGF release in vascular smooth muscle cells. Simvastatin 91-102 vascular endothelial growth factor A Rattus norvegicus 114-118 18569938-0 2008 Simvastatin alleviates diabetes-induced VEGF-mediated nephropathy via the modulation of Ras signaling pathway. Simvastatin 0-11 vascular endothelial growth factor A Rattus norvegicus 40-44 18569938-2 2008 We examined the role of simvastatin in modulating Ras signaling and the expression of VEGF in mesangial cells stressed with high doses of glucose in vitro and in vivo. Simvastatin 24-35 vascular endothelial growth factor A Rattus norvegicus 86-90 18569938-6 2008 The pretreatment with 10 microM simvastatin and inhibition of Ras activity by manumycin A significantly reversed high glucose promotion of VEGF mRNA expression. Simvastatin 32-43 vascular endothelial growth factor A Rattus norvegicus 139-143 34147541-9 2021 Simvastatin increased levels of circulating EPCs and decreased iNOS, MMP-2, MMP-9 and VEGF mRNA levels, while increased eNOS mRNA in aneurysmal tissue. Simvastatin 0-11 vascular endothelial growth factor A Rattus norvegicus 86-90 32133066-10 2019 Simvastatin could promote expressions of aggrecan, collagen type II, HIF-1alpha, VEGF and GLUT-1, while 0.1 mumol/l concentration reached the maximum effect. Simvastatin 0-11 vascular endothelial growth factor A Rattus norvegicus 81-85 30233664-0 2018 Effect of simvastatin on expression of VEGF and TGF-beta1 in atherosclerotic animal model of type 2 diabetes mellitus. Simvastatin 10-21 vascular endothelial growth factor A Rattus norvegicus 39-43 30233664-1 2018 Expression of vascular endothelial growth factor (VEGF) and transforming growth factor-beta1 (TGF-beta1) in atherosclerosis animal model of type 2 diabetes mellitus treated with simvastatin was investigated. Simvastatin 178-189 vascular endothelial growth factor A Rattus norvegicus 14-48 30233664-1 2018 Expression of vascular endothelial growth factor (VEGF) and transforming growth factor-beta1 (TGF-beta1) in atherosclerosis animal model of type 2 diabetes mellitus treated with simvastatin was investigated. Simvastatin 178-189 vascular endothelial growth factor A Rattus norvegicus 50-54 30233664-14 2018 Simvastatin may play a therapeutic role in T2MD AS by downregulating VEGF and upregulating the expression of TGF-beta1. Simvastatin 0-11 vascular endothelial growth factor A Rattus norvegicus 69-73 30056191-6 2018 Simvastatin increased some factors attenuated by glucose fluctuations: mRNA VEGF expression and mRNA VEGFR-1 expression in the myocardium and in the aorta. Simvastatin 0-11 vascular endothelial growth factor A Rattus norvegicus 76-80 27856999-6 2017 Interestingly, simvastatin treatment significantly increased VEGF and IL-10 levels while decreased sFlt-1, TNF-alpha, and MDA levels compared to the untreated l-NAME group. Simvastatin 15-26 vascular endothelial growth factor A Rattus norvegicus 61-65 30056191-5 2018 RESULTS: Simvastatin decreased several factors enhanced by glucose excursions: circulating VEGF, mRNA TGF-beta expression in the myocardium and mRNA VEGFR-2 expression in the aorta. Simvastatin 9-20 vascular endothelial growth factor A Rattus norvegicus 91-95 26770424-0 2015 Effect of simvastatin on the expression of nephrin, podocin, and vascular endothelial growth factor (VEGF) in podocytes of diabetic rat. Simvastatin 10-21 vascular endothelial growth factor A Rattus norvegicus 65-99 26770424-0 2015 Effect of simvastatin on the expression of nephrin, podocin, and vascular endothelial growth factor (VEGF) in podocytes of diabetic rat. Simvastatin 10-21 vascular endothelial growth factor A Rattus norvegicus 101-105 26770424-9 2015 Simvastatin (SVT) could reduce serum creatinine levels and the UAER, maintain the expression of nephrin and podocin, reduce the expression of VEGF, and improve the pathological changes of podocytes, which were much more pronounced at 8 weeks (P < 0.01). Simvastatin 0-11 vascular endothelial growth factor A Rattus norvegicus 142-146 26770424-10 2015 Simvastatin could maintain the distribution of nephrin and podocin in podocytes, inhibit VEGF expression, and thus improve podocyte injuries and protect kidney functions in diabetic rats. Simvastatin 0-11 vascular endothelial growth factor A Rattus norvegicus 89-93 26239701-12 2015 Simvastatin exerted a significant impact on the expression of VEGF and attenuated cigarette smoke-induced emphysema in rats. Simvastatin 0-11 vascular endothelial growth factor A Rattus norvegicus 62-66