PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22147704-3	2012	The oxidized active site cysteine of Prx can be reduced by a cellular thiol, thus enabling Prx to function as a locally constrained peroxidase.	Sulfhydryl Compounds	70-75	periaxin	Homo sapiens	37-40	
31019520-9	2019	Here, we update the current knowledge of these two redox systems focusing on recent evidence showing their functional interrelationship through the action of the thiol-dependent peroxidase, 2-Cys peroxiredoxin (2-Cys Prx).	Sulfhydryl Compounds	162-167	periaxin	Homo sapiens	217-220	
22147704-3	2012	The oxidized active site cysteine of Prx can be reduced by a cellular thiol, thus enabling Prx to function as a locally constrained peroxidase.	Sulfhydryl Compounds	70-75	periaxin	Homo sapiens	91-94	
21466852-1	2011	Peroxiredoxins (Prx"s) are a family of peroxidases that maintain thiol homeostasis by catalyzing the reduction of organic hydroperoxides, H2O2, and peroxynitrite.	Sulfhydryl Compounds	65-70	periaxin	Homo sapiens	16-19	
18179358-3	2008	Our study shows that the thiol status of the Trx/Prx-system can be modulated in vitro, but it appears to have high resistance against the oxidative stress in COPD.	Sulfhydryl Compounds	25-30	periaxin	Homo sapiens	49-52	
19462976-5	2009	In contrast, Prx 3 reacted very slowly with the thiol alkylating agents iodoacetamide and N-ethylmaleimide.	Sulfhydryl Compounds	48-53	periaxin	Homo sapiens	13-16	
18279387-1	2008	2-Cys peroxiredoxins (2-Cys Prx) are ubiquitous thiol-containing peroxidases that have been implicated in antioxidant defense and signal transduction.	Sulfhydryl Compounds	48-53	periaxin	Homo sapiens	28-31	
18279387-5	2008	More importantly, we found that ATP facilitates the autophosphorylation of 2-Cys Prx when the protein is successively reduced with thiol-bearing compounds and oxidized with hydroperoxides or quinones.	Sulfhydryl Compounds	131-136	periaxin	Homo sapiens	81-84	
16565085-6	2006	This ester is reductively cleaved by a thiol molecule (RSH) such as GSH, thioredoxin, and dithiothreitol to produce a disulfide-S-monoxide (Prx-Cys-S(=O)-S-R).	Sulfhydryl Compounds	39-44	periaxin	Homo sapiens	140-143	
16565085-7	2006	The disulfide-S-monoxide is further reduced through the oxidation of three thiol equivalents to complete the catalytic cycle and regenerate Prx-Cys-SH.	Sulfhydryl Compounds	75-80	periaxin	Homo sapiens	140-143