PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9150702-1	1997	OBJECTIVE: To determine whether hyperinsulinism affects cytochrome P450c17 alpha activity by investigating the correlation between 17-hydroxyprogesterone (17-OHP) hyper-responsiveness to the gonadotropin-releasing hormone (GnRH) agonist, buserelin, and the insulin response to oral glucose in polycystic ovary syndrome (PCOS).	17-alpha-Hydroxyprogesterone	131-153	insulin	Homo sapiens	37-44	
18439591-9	2009	In decreasing order of importance, the following variables predicted insulin resistance: BMI > WHR > age > DHEAS > free T > SHBG > 17-OHP.	17-alpha-Hydroxyprogesterone	149-155	insulin	Homo sapiens	69-76	
17785360-11	2007	In a multiple regression model applied in all PCOS women, insulin(AUC) but not androgens or markers of insulin resistance predicted the 17-hydroxyprogesterone response to buserelin to a highly significant extent (t = 3.269; P < 0.01).	17-alpha-Hydroxyprogesterone	136-158	insulin	Homo sapiens	58-65	
17785360-13	2007	We have shown that women with an exaggerated 17-hydroxyprogesterone response to a GnRH agonist, buserelin, are characterized by more severe hyperandrogenemia, glucose-stimulated beta-cell insulin secretion, and worse insulin resistance than those without evidence of FOH.	17-alpha-Hydroxyprogesterone	45-67	insulin	Homo sapiens	188-195	
17785360-13	2007	We have shown that women with an exaggerated 17-hydroxyprogesterone response to a GnRH agonist, buserelin, are characterized by more severe hyperandrogenemia, glucose-stimulated beta-cell insulin secretion, and worse insulin resistance than those without evidence of FOH.	17-alpha-Hydroxyprogesterone	45-67	insulin	Homo sapiens	217-224	
11915581-8	2002	In the nafarelin test increases of 17-OH-progesterone and androstenedione were higher in patients and positively correlated with fasting insulin levels.	17-alpha-Hydroxyprogesterone	35-53	insulin	Homo sapiens	137-144	
10468995-4	1999	The aim of the present study was to determine whether reduction of insulin levels by metformin would attenuate FSH, LH, 17-Hydroxyprogesterone (17-OHP) and androstenedione hyperresponsiveness to buserelin testing in PCOS women.	17-alpha-Hydroxyprogesterone	120-142	insulin	Homo sapiens	67-74	
10468995-4	1999	The aim of the present study was to determine whether reduction of insulin levels by metformin would attenuate FSH, LH, 17-Hydroxyprogesterone (17-OHP) and androstenedione hyperresponsiveness to buserelin testing in PCOS women.	17-alpha-Hydroxyprogesterone	144-150	insulin	Homo sapiens	67-74	
21059865-7	2011	RESULTS: During insulin infusion, ACTH-stimulated 17-OHPREG and 17-OHP were significantly higher than during saline infusion.	17-alpha-Hydroxyprogesterone	50-56	insulin	Homo sapiens	16-23	
15956788-10	2005	Insulin levels were correlated with fT and 17-OHP (p < 0.05).	17-alpha-Hydroxyprogesterone	43-49	insulin	Homo sapiens	0-7	
9150702-1	1997	OBJECTIVE: To determine whether hyperinsulinism affects cytochrome P450c17 alpha activity by investigating the correlation between 17-hydroxyprogesterone (17-OHP) hyper-responsiveness to the gonadotropin-releasing hormone (GnRH) agonist, buserelin, and the insulin response to oral glucose in polycystic ovary syndrome (PCOS).	17-alpha-Hydroxyprogesterone	155-161	insulin	Homo sapiens	37-44	
9150702-3	1997	We investigated the correlation between the 17-OHP response to buserelin testing and the insulin response to oral glucose in PCOS.	17-alpha-Hydroxyprogesterone	44-50	insulin	Homo sapiens	89-96	
1730815-7	1992	The insulin-induced change in this steroid ratio was due to a relative increase in precursor (17 alpha-hydroxyprogesterone) and decrease in product (androstenedione) responsiveness to ACTH.	17-alpha-Hydroxyprogesterone	94-122	insulin	Homo sapiens	4-11	
8772544-8	1996	ACTH-stimulated serum 17-OHPREG and, to a lesser extent, 17-OHP were significantly higher during insulin than during saline infusion (peaks, 60.6 +/- 9.0 vs. 40.7 +/- 7.9 and 7.7 +/- 7.7 vs. 6.6 +/- 0.6 nmol/L; P < 0.005 and P < 0.01, respectively).	17-alpha-Hydroxyprogesterone	22-28	insulin	Homo sapiens	97-104	
25491105-10	2015	RESULTS: Basal and/or stimulated Testosterone DHEA-S and 17-hydroxyprogesterone (17OHP) were inversely associated with insulin sensitivity (WIBSI) from the beginning of puberty, whereas androstenedione was directly associated with gonadotrophins.	17-alpha-Hydroxyprogesterone	57-79	insulin	Homo sapiens	119-126	
6986393-5	1980	An inverse relationship was found between insulin binding to monocytes and levels of 17 beta-estradiol, progesterone, and 17 alpha-hydroxyprogesterone; this relationship was not observed in insulin binding to erythrocytes.	17-alpha-Hydroxyprogesterone	122-150	insulin	Homo sapiens	42-49	
35480632-8	2022	The homeostatic model assessment of insulin resistance was positively associated with androstenedione (beta = 0.071, P = .032), estradiol (beta = 0.091, P = .009), estrone (beta = 0.075, P = 0.009), and 17-alpha-hydroxyprogesterone (beta = 0.157, P = .001).	17-alpha-Hydroxyprogesterone	203-231	insulin	Homo sapiens	36-43	
33260786-11	2020	Body fat percentage and insulin resistance were negatively related to 17-OH progesterone levels, whereas FT and ACTH levels were positively associated with 17-OH progesterone levels.	17-alpha-Hydroxyprogesterone	70-88	insulin	Homo sapiens	24-31	
25491105-10	2015	RESULTS: Basal and/or stimulated Testosterone DHEA-S and 17-hydroxyprogesterone (17OHP) were inversely associated with insulin sensitivity (WIBSI) from the beginning of puberty, whereas androstenedione was directly associated with gonadotrophins.	17-alpha-Hydroxyprogesterone	81-86	insulin	Homo sapiens	119-126	
23076844-8	2013	In all women, waist circumference was a negative predictor for ISI; 17-OHP and FAI levels were positive predictors respectively for baseline insulin levels and for 1st PHIS and 2nd PHIS.	17-alpha-Hydroxyprogesterone	68-74	insulin	Homo sapiens	141-148	
22985947-11	2012	CONCLUSION(S): Girls at high risk of developing PCOS display increased adiposity and 17-OHP levels, but are mainly characterized by global insulin resistance and resistance to insulin-induced suppression of lipolysis that were independent of adiposity and 17-OHP levels.	17-alpha-Hydroxyprogesterone	256-262	insulin	Homo sapiens	176-183