PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21482471-7 2011 HPLC metabolism of acacetin by CYP1A1 and CYP1B1 revealed the formation of the structurally similar flavone apigenin by demethylation at the 4"-position of the B ring, whereas the flavone eupatorin-5-methyl ether was metabolized to an as yet unidentified metabolite assigned E(5)M1. flavone 100-107 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 42-48 22743247-6 2012 The intracellular CYP1-mediated bioconversion of the flavone was reduced in the presence of the CYP1A1 and CYP1B1-selective inhibitors alpha-napthoflavone and acacetin. flavone 53-60 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 107-113 28119082-4 2017 Herein, we investigated the inhibitory activity of fisetin and flavone against CYP1B1 using estrogen E2 as substrate in vitro to reveal structure-activity relationship between structure of flavonoids and inhibition. flavone 63-70 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 79-85 19424633-5 2009 We suggest that diosmetin exerts cytostatic effects in MDA-MB 468 cells, due to CYP1A1 and CYP1B1 catalyzed conversion to the flavone luteolin. flavone 126-133 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 91-97 17637178-0 2007 Novel methoxylated flavone inhibitors of cytochrome P450 1B1 in SCC-9 human oral cancer cells. flavone 19-26 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 41-60 15890477-5 2005 The effect observed here after pretreatment with oltipraz, flavone and I3C was the result of the induction of both CYP1A1 and CYP1B1, as was confirmed by analysis of CYP1A1 (protein and mRNA) and CYP1B1 (mRNA) expression. flavone 59-66 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 126-132 15890477-5 2005 The effect observed here after pretreatment with oltipraz, flavone and I3C was the result of the induction of both CYP1A1 and CYP1B1, as was confirmed by analysis of CYP1A1 (protein and mRNA) and CYP1B1 (mRNA) expression. flavone 59-66 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 196-202 15890477-6 2005 In summary, our study shows that the induction of both CYP1A1 and CYP1B1 resulted in an accelerated metabolism and an enhanced clearance of the potent procarcinogen BP, indicating that flavone, indole-3-carbinol and oltipraz have an impact on the biochemical barrier against BP in intestinal cells. flavone 185-192 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 66-72