PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21482471-7	2011	HPLC metabolism of acacetin by CYP1A1 and CYP1B1 revealed the formation of the structurally similar flavone apigenin by demethylation at the 4"-position of the B ring, whereas the flavone eupatorin-5-methyl ether was metabolized to an as yet unidentified metabolite assigned E(5)M1.	flavone	100-107	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	42-48	
22743247-6	2012	The intracellular CYP1-mediated bioconversion of the flavone was reduced in the presence of the CYP1A1 and CYP1B1-selective inhibitors alpha-napthoflavone and acacetin.	flavone	53-60	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	107-113	
28119082-4	2017	Herein, we investigated the inhibitory activity of fisetin and flavone against CYP1B1 using estrogen E2 as substrate in vitro to reveal structure-activity relationship between structure of flavonoids and inhibition.	flavone	63-70	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	79-85	
19424633-5	2009	We suggest that diosmetin exerts cytostatic effects in MDA-MB 468 cells, due to CYP1A1 and CYP1B1 catalyzed conversion to the flavone luteolin.	flavone	126-133	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	91-97	
17637178-0	2007	Novel methoxylated flavone inhibitors of cytochrome P450 1B1 in SCC-9 human oral cancer cells.	flavone	19-26	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	41-60	
15890477-5	2005	The effect observed here after pretreatment with oltipraz, flavone and I3C was the result of the induction of both CYP1A1 and CYP1B1, as was confirmed by analysis of CYP1A1 (protein and mRNA) and CYP1B1 (mRNA) expression.	flavone	59-66	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	126-132	
15890477-5	2005	The effect observed here after pretreatment with oltipraz, flavone and I3C was the result of the induction of both CYP1A1 and CYP1B1, as was confirmed by analysis of CYP1A1 (protein and mRNA) and CYP1B1 (mRNA) expression.	flavone	59-66	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	196-202	
15890477-6	2005	In summary, our study shows that the induction of both CYP1A1 and CYP1B1 resulted in an accelerated metabolism and an enhanced clearance of the potent procarcinogen BP, indicating that flavone, indole-3-carbinol and oltipraz have an impact on the biochemical barrier against BP in intestinal cells.	flavone	185-192	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	66-72