PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26573806-9 2016 CONCLUSION: It can be assumed that our observations are due to the independent regulatory function of AKR1C1/2 in progesterone metabolism and therefore provide a basis for new hormone-based therapy options for breast cancer patients, independent of classic hormone receptor status. Progesterone 114-126 aldo-keto reductase family 1 member C1 Homo sapiens 102-108 32872468-5 2020 They had been screened by whole exome sequencing (WES) which led to the discovery of a missense variant p.(Leu213Gln) in AKR1C1, the gene encoding for an aldo-keto reductase catalyzing the reduction of progesterone to its inactive form, 20-alpha-hydroxyprogesterone. Progesterone 202-214 aldo-keto reductase family 1 member C1 Homo sapiens 121-127 31333491-0 2019 Liquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism. Progesterone 71-83 aldo-keto reductase family 1 member C1 Homo sapiens 38-44 31333491-3 2019 Aldo-keto reductase family one member C1 (AKR1C1) catalyzes the reduction of progesterone to its inactive form of 20-alpha-hydroxy-progesterone and thus limits the biological effect of progesterone. Progesterone 77-89 aldo-keto reductase family 1 member C1 Homo sapiens 42-48 31333491-3 2019 Aldo-keto reductase family one member C1 (AKR1C1) catalyzes the reduction of progesterone to its inactive form of 20-alpha-hydroxy-progesterone and thus limits the biological effect of progesterone. Progesterone 131-143 aldo-keto reductase family 1 member C1 Homo sapiens 42-48 31333491-6 2019 In HEC-1-B cells, treatment with liquiritin results in 85.00% of reduction in progesterone metabolism, which is mediated by AKR1C1 enzymatic activity. Progesterone 78-90 aldo-keto reductase family 1 member C1 Homo sapiens 124-130 24390875-9 2014 CONCLUSIONS: These results suggest a modulatory effect of AKR1C1 activity on anxiety levels, most likely through changes in progesterone and allopregnanolone levels within and outside the brain. Progesterone 124-136 aldo-keto reductase family 1 member C1 Homo sapiens 58-64 25463305-10 2015 AKR1C1/AKR1C2 gene silencing showed decreased progesterone metabolism in both cell lines, thus further supporting the significant role of AKR1C2. Progesterone 46-58 aldo-keto reductase family 1 member C1 Homo sapiens 0-6 23183084-10 2013 In contrast, treatment with medroxyprogesterone acetate resulted in increased AKR1C1 expression and decreased levels of PR-B, which might lead to enhanced progesterone metabolism and reduced signaling through progesterone receptors. Progesterone 35-47 aldo-keto reductase family 1 member C1 Homo sapiens 78-84 22419909-11 2012 The AKR1C1-AKR1C3 enzymes also act as 17-keto- and 20-ketosteroid reductases to varying extents, and are implicated in increased estradiol and decreased progesterone levels. Progesterone 153-165 aldo-keto reductase family 1 member C1 Homo sapiens 4-17 22245609-6 2012 The recombinant enzyme catalyses reduction of progesterone to 20alpha-hydroxyprogesterone with a 10-fold lower catalytic efficiency than the major 20-ketosteroid reductase, AKR1C1. Progesterone 46-58 aldo-keto reductase family 1 member C1 Homo sapiens 173-179 22064385-10 2012 Use of specific inhibitors for aldo-keto reductases or 5alpha reductases confirmed that the increased progesterone metabolism was a consequence of the increased expression and/or activity of AKR1C1/2. Progesterone 102-114 aldo-keto reductase family 1 member C1 Homo sapiens 191-199 22064385-11 2012 Our results indicate that a major proinflammatory cytokine, IL-1beta, can facilitate local progesterone metabolism in a cell type critical for maintaining cervical structure via regulating expression of AKR1C1 and 2. Progesterone 91-103 aldo-keto reductase family 1 member C1 Homo sapiens 203-215 21521174-7 2011 Comparison of the kinetics of the AKR1C1-AKR1C4-catalysed reactions with those of AKR1D1 suggested that the three intermediate 5beta-dihydrosteroids derived from testosterone and progesterone are unlikely to accumulate in liver, and that the identities and levels of 5beta-reduced metabolites formed in peripheral tissues will be governed by the local expression of AKR1D1 and AKR1C1-AKR1C3. Progesterone 179-191 aldo-keto reductase family 1 member C1 Homo sapiens 34-47 21521174-7 2011 Comparison of the kinetics of the AKR1C1-AKR1C4-catalysed reactions with those of AKR1D1 suggested that the three intermediate 5beta-dihydrosteroids derived from testosterone and progesterone are unlikely to accumulate in liver, and that the identities and levels of 5beta-reduced metabolites formed in peripheral tissues will be governed by the local expression of AKR1D1 and AKR1C1-AKR1C3. Progesterone 179-191 aldo-keto reductase family 1 member C1 Homo sapiens 377-390 21217827-1 2010 Enzymes encoded by the AKR1C1 and AKR1C2 genes are responsible for the metabolism of progesterone and 5alpha-dihydrotestosterone (DHT), respectively. Progesterone 85-97 aldo-keto reductase family 1 member C1 Homo sapiens 23-29 21182831-1 2011 The human aldo-keto reductases 1C1 and 1C3 (AKR1C1 and AKR1C3) are important 20-ketosteroid reductases in pre-receptor regulation of progesterone action. Progesterone 133-145 aldo-keto reductase family 1 member C1 Homo sapiens 44-50 21182831-2 2011 Both AKR1C1 and AKR1C3 convert progesterone to the less potent metabolite 20alpha-hydroxyprogesterone, although AKR1C1 has a higher catalytic efficiency than AKR1C3. Progesterone 31-43 aldo-keto reductase family 1 member C1 Homo sapiens 5-11 21182831-2 2011 Both AKR1C1 and AKR1C3 convert progesterone to the less potent metabolite 20alpha-hydroxyprogesterone, although AKR1C1 has a higher catalytic efficiency than AKR1C3. Progesterone 31-43 aldo-keto reductase family 1 member C1 Homo sapiens 112-118 21182831-7 2011 We examined the following progestins as inhibitors of progesterone reduction catalyzed by recombinant AKR1C1 and AKR1C3: progesterone derivatives (dydrogesterone, its metabolite, 20alpha-hydroxydydrogesterone; and medroxyprogesterone acetate), 19-nortestosterone derivatives (desogestrel, norethinodrone and levonorgestrel), and the androgen danazol. Progesterone 54-66 aldo-keto reductase family 1 member C1 Homo sapiens 102-108 21182831-7 2011 We examined the following progestins as inhibitors of progesterone reduction catalyzed by recombinant AKR1C1 and AKR1C3: progesterone derivatives (dydrogesterone, its metabolite, 20alpha-hydroxydydrogesterone; and medroxyprogesterone acetate), 19-nortestosterone derivatives (desogestrel, norethinodrone and levonorgestrel), and the androgen danazol. Progesterone 121-133 aldo-keto reductase family 1 member C1 Homo sapiens 102-108 21232532-0 2011 Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis. Progesterone 59-71 aldo-keto reductase family 1 member C1 Homo sapiens 21-27 21232532-10 2011 Our expression analysis data at the mRNA level and partially at the cellular level thus suggest enhanced metabolism of progesterone by SRD5A1 and the 20alpha-HSD and 3alpha/beta-HSD activities of AKR1C1, AKR1C2 and AKR1C3. Progesterone 119-131 aldo-keto reductase family 1 member C1 Homo sapiens 196-202 21050889-2 2011 AKR1C1 most efficiently reduces biologically active progesterone and 5alpha-pregnan-3alpha-ol-20-one into their corresponding 20alpha-hydroxysteroids among the isoforms. Progesterone 52-64 aldo-keto reductase family 1 member C1 Homo sapiens 0-6 18930784-7 2009 Up-regulation of AKR1C1 and AKR1C3 can result in lower levels of the protective progesterone, which acts mainly via PR-B. Progesterone 80-92 aldo-keto reductase family 1 member C1 Homo sapiens 17-23 20727920-4 2010 In this study, we have functionally expressed human AKR1C1 (20alpha-hydroxysteroid dehydrogenase) in the fission yeast Schizosaccharomyces pombe and demonstrate the ability of the resulting yeast strain to efficiently catalyze the reduction of progesterone or dydrogesterone to 20alpha-dihydroprogesterone (20alpha-DHP) and 20alpha-dihydrodydrogesterone (20alpha-DHD), respectively. Progesterone 244-256 aldo-keto reductase family 1 member C1 Homo sapiens 52-58 20727920-4 2010 In this study, we have functionally expressed human AKR1C1 (20alpha-hydroxysteroid dehydrogenase) in the fission yeast Schizosaccharomyces pombe and demonstrate the ability of the resulting yeast strain to efficiently catalyze the reduction of progesterone or dydrogesterone to 20alpha-dihydroprogesterone (20alpha-DHP) and 20alpha-dihydrodydrogesterone (20alpha-DHD), respectively. Progesterone 244-256 aldo-keto reductase family 1 member C1 Homo sapiens 60-96 19320734-4 2009 AKR1C1 and AKR1C2 inactivate progesterone and 5alpha-dihydrotestosterone, respectively, whereas AKR1C3 activates oestradiol and testosterone. Progesterone 29-41 aldo-keto reductase family 1 member C1 Homo sapiens 0-6 18762229-3 2009 Expression analysis revealed significant up-regulation of enzymes involved in estradiol formation (aromatase, sulfatase and all reductive 17beta-hydroxysteroid dehydrogenases) and in progesterone inactivation (AKR1C1 and AKR1C3). Progesterone 183-195 aldo-keto reductase family 1 member C1 Homo sapiens 210-216 19007763-3 2009 AKR1C1 thus decreases the levels of progesterone and 5alpha-THP in peripheral tissue. Progesterone 36-48 aldo-keto reductase family 1 member C1 Homo sapiens 0-6 12899831-1 2003 Human 20alpha-hydroxysteroid dehydrogenase (h20alpha-HSD; AKR1C1) catalyzes the transformation of progesterone (Prog) into 20alpha-hydroxy-progesterone (20alpha-OHProg). Progesterone 98-110 aldo-keto reductase family 1 member C1 Homo sapiens 6-42 18770491-1 2008 We sought to determine relative mRNA expression of AKR1C1 and SRD5A1, which respectively encode for the key progesterone metabolizing enzymes, 20alpha-hydroxysteroid dehydrogenase and 5alpha-reductase type 1, in the myometrium and chorioamniotic membranes during human spontaneous or induced labor and nonlabor. Progesterone 108-120 aldo-keto reductase family 1 member C1 Homo sapiens 51-57 15212687-0 2004 Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma. Progesterone 14-26 aldo-keto reductase family 1 member C1 Homo sapiens 54-60 18984031-3 2009 In isolated mature adipocytes, progesterone was converted to 20alpha-hydroxyprogesterone as the main metabolite, most likely through the activity of aldo-keto reductases 1C1, 2 and 3 (20alpha-HSD, 3alpha-HSD type 3 and 17beta-HSD type 5, respectively). Progesterone 31-43 aldo-keto reductase family 1 member C1 Homo sapiens 184-195 18045204-1 2007 20alpha-hydroxysteroid dehydrogenase (AKR1C1) plays a key role in the metabolism of progesterone and other steroid hormones, thereby regulating their action at the pre-receptor level. Progesterone 84-96 aldo-keto reductase family 1 member C1 Homo sapiens 0-36 18045204-1 2007 20alpha-hydroxysteroid dehydrogenase (AKR1C1) plays a key role in the metabolism of progesterone and other steroid hormones, thereby regulating their action at the pre-receptor level. Progesterone 84-96 aldo-keto reductase family 1 member C1 Homo sapiens 38-44 16962702-4 2006 We have examined the inhibitory action of phytoestrogens on the key human progesterone-metabolizing enzyme, 20alpha-hydroxysteroid dehydrogenase (AKR1C1). Progesterone 74-86 aldo-keto reductase family 1 member C1 Homo sapiens 108-144 16962702-4 2006 We have examined the inhibitory action of phytoestrogens on the key human progesterone-metabolizing enzyme, 20alpha-hydroxysteroid dehydrogenase (AKR1C1). Progesterone 74-86 aldo-keto reductase family 1 member C1 Homo sapiens 146-152 15492289-0 2004 Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling. Progesterone 83-95 aldo-keto reductase family 1 member C1 Homo sapiens 18-24 15492289-9 2004 Suppression of AKR1C1 alone or with AKR1C2 in T-47D cells led to decreased growth in the presence of progesterone. Progesterone 101-113 aldo-keto reductase family 1 member C1 Homo sapiens 15-21 15492289-11 2004 We speculate that loss of AKR1C1 and AKR1C2 in breast cancer results in decreased progesterone catabolism, which, in combination with increased PR expression, may augment progesterone signaling by its nuclear receptors. Progesterone 82-94 aldo-keto reductase family 1 member C1 Homo sapiens 26-32 15492289-11 2004 We speculate that loss of AKR1C1 and AKR1C2 in breast cancer results in decreased progesterone catabolism, which, in combination with increased PR expression, may augment progesterone signaling by its nuclear receptors. Progesterone 171-183 aldo-keto reductase family 1 member C1 Homo sapiens 26-32 12899831-1 2003 Human 20alpha-hydroxysteroid dehydrogenase (h20alpha-HSD; AKR1C1) catalyzes the transformation of progesterone (Prog) into 20alpha-hydroxy-progesterone (20alpha-OHProg). Progesterone 98-110 aldo-keto reductase family 1 member C1 Homo sapiens 58-64 12899831-1 2003 Human 20alpha-hydroxysteroid dehydrogenase (h20alpha-HSD; AKR1C1) catalyzes the transformation of progesterone (Prog) into 20alpha-hydroxy-progesterone (20alpha-OHProg). Progesterone 112-116 aldo-keto reductase family 1 member C1 Homo sapiens 6-42 12899831-1 2003 Human 20alpha-hydroxysteroid dehydrogenase (h20alpha-HSD; AKR1C1) catalyzes the transformation of progesterone (Prog) into 20alpha-hydroxy-progesterone (20alpha-OHProg). Progesterone 112-116 aldo-keto reductase family 1 member C1 Homo sapiens 58-64 11995921-2 2002 AKR1C1 efficiently reduced 3alpha,5alpha-THP, 5alpha-DHP and progesterone to their 20alpha-hydroxy metabolites, and slowly converted 5alpha-DHDOC to 3alpha,5alpha-THDOC. Progesterone 61-73 aldo-keto reductase family 1 member C1 Homo sapiens 0-6 12604236-0 2003 Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone. Progesterone 131-143 aldo-keto reductase family 1 member C1 Homo sapiens 41-77 12604236-0 2003 Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone. Progesterone 131-143 aldo-keto reductase family 1 member C1 Homo sapiens 79-85 10672042-1 2000 BACKGROUND: 20alpha-Hydroxysteroid dehydrogenase (HSD) is a member of the aldo-keto reductase (AKR) superfamily and catalyses the reaction of progesterone to the inactive form 20alpha-hydroxyprogesterone. Progesterone 142-154 aldo-keto reductase family 1 member C1 Homo sapiens 12-48 11306084-9 2001 The enzyme was converted to a robust 20alpha-HSD, which is positional and stereospecific for 20-ketosteroids and inactivates progesterone, by the generation of loop-chimeras. Progesterone 125-137 aldo-keto reductase family 1 member C1 Homo sapiens 37-48 10672042-12 2000 CONCLUSION: The human gene encoding for the progesterone-metabolizing enzyme 20alpha-HSD in the female reproductive system was cloned, and its expression and gene localization were elucidated. Progesterone 44-56 aldo-keto reductase family 1 member C1 Homo sapiens 77-88 10672042-1 2000 BACKGROUND: 20alpha-Hydroxysteroid dehydrogenase (HSD) is a member of the aldo-keto reductase (AKR) superfamily and catalyses the reaction of progesterone to the inactive form 20alpha-hydroxyprogesterone. Progesterone 142-154 aldo-keto reductase family 1 member C1 Homo sapiens 50-53 10672042-3 2000 The induction of 20alpha-HSD is thought to be responsible for the decrease in plasma progesterone at term. Progesterone 85-97 aldo-keto reductase family 1 member C1 Homo sapiens 17-28 33770316-1 2021 Aldo-keto reductase 1C1 (AKR1C1) is a hydroxysteroid dehydrogenase, known to inactivate the biologically active progesterone into its corresponding 20 alpha-hydroxyprogesterone. Progesterone 112-124 aldo-keto reductase family 1 member C1 Homo sapiens 0-23 33770316-1 2021 Aldo-keto reductase 1C1 (AKR1C1) is a hydroxysteroid dehydrogenase, known to inactivate the biologically active progesterone into its corresponding 20 alpha-hydroxyprogesterone. Progesterone 112-124 aldo-keto reductase family 1 member C1 Homo sapiens 25-31 34780792-1 2022 Human aldo-keto reductase family 1C1 (AKR1C1) is an important enzyme involved in human hormone metabolism, which is mainly responsible for the metabolism of progesterone in the human body. Progesterone 157-169 aldo-keto reductase family 1 member C1 Homo sapiens 6-36 34780792-1 2022 Human aldo-keto reductase family 1C1 (AKR1C1) is an important enzyme involved in human hormone metabolism, which is mainly responsible for the metabolism of progesterone in the human body. Progesterone 157-169 aldo-keto reductase family 1 member C1 Homo sapiens 38-44