PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31327274-0 2019 Progesterone Predisposes Females to Obesity-Associated Leptin-Mediated Endothelial Dysfunction via Upregulating Endothelial MR (Mineralocorticoid Receptor) Expression. Progesterone 0-12 leptin Homo sapiens 55-61 32772182-9 2020 Leptin level was positively associated with glycocholic acid and arachidic acid, metabolites related to energy metabolisms, pregnanediol-3-glucuronide, a metabolite of progesterone metabolism, and quercetin 3"-sulfate, a diet-derived metabolite. Progesterone 168-180 leptin Homo sapiens 0-6 32025443-13 2019 CONCLUSION: Low levels of leptin observed to have an increase in the BMI of UI females were associated with a reduced estradiol and progesterone production in the luteal phase of the cycle. Progesterone 132-144 leptin Homo sapiens 26-32 23853617-7 2013 Leptin was positively correlated with FSH on day 14, with LH on day 7 and day 21; likewise, with progesterone on day 21 and day 28 and with estradiol on day 7 and day 14 for both age groups. Progesterone 97-109 leptin Homo sapiens 0-6 26516305-0 2015 Progesterone Inhibits Leptin-Induced Invasiveness of BeWo Cells. Progesterone 0-12 leptin Homo sapiens 22-28 25483293-10 2015 A positive correlation was found between leptin and PRL concentrations during mid (r=0.430; P<0.001) and late (r=0.687; P<0.001) pregnancy, and with progesterone in early pregnancy (r=0.462; P<0.05). Progesterone 155-167 leptin Homo sapiens 41-47 24101399-0 2013 In vitro effects of luteinizing hormone, progesterone and oestradiol-17beta on leptin gene expression and leptin secretion by porcine luteal cells obtained in early pregnancy. Progesterone 41-53 leptin Homo sapiens 79-85 16987633-1 2007 Infusion of leptin during the ovine follicular phase has been shown to increase progesterone secretion during the subsequent luteal phase. Progesterone 80-92 leptin Homo sapiens 12-18 19794290-5 2009 In particular, leptin at low concentrations stimulated the secretion of estradiol (1 and 10 ng/ml) and progesterone (10 ng/ml), while at a high concentration (100 ng/ml) it suppressed the secretion of both steroids. Progesterone 103-115 leptin Homo sapiens 15-21 21287461-14 2010 Serum leptin concentration negatively correlated with LH and progesterone (P<0.05). Progesterone 61-73 leptin Homo sapiens 6-12 14974912-10 2003 Before therapy, leptin levels were positively correlated both with oestradiol and progesterone in the follicular and luteal phase in all groups. Progesterone 82-94 leptin Homo sapiens 16-22 16048798-3 2005 In the present study we examined the effect of gestational hormones, human chorionic gonadotropin (hCG), human placental lactogen (hPL), progesterone and estradiol, on in vitro leptin release by human term trophoblast cells in culture. Progesterone 137-149 leptin Homo sapiens 177-183 12914539-8 2003 Using a sensitive radioimmunoassay (lower limit of detection 0.05 ng/ml), leptin was undetectable in the culture media at all points during the 72 h cultures, while at the same time significant amounts of oestradiol and progesterone were produced particularly after the addition of androstendione (1 microM) to the incubation media. Progesterone 220-232 leptin Homo sapiens 74-80 12533410-3 2003 In the present study, we investigated the role of leptin in the secretion of hCG, progesterone, and interleukin-6 (IL-6) by human term trophoblast cells in culture. Progesterone 82-94 leptin Homo sapiens 50-56 12604627-2 2003 In porcine granulosa cells in culture over 48 h, leptin at 10 ng/ml increased progesterone accumulation 3-fold while it was reduced by leptin at 1000 ng/ml. Progesterone 78-90 leptin Homo sapiens 49-55 12533410-6 2003 Recombinant human leptin added to primary cultures of human term placental trophoblast cells showed a stimulatory effect on hCG and IL-6 secretion and an inhibitory effect on progesterone secretion. Progesterone 175-187 leptin Homo sapiens 18-24 11527883-0 2001 Oestradiol plus progesterone treatment increases serum leptin concentrations in normal women. Progesterone 16-28 leptin Homo sapiens 55-61 12036084-9 2002 CONCLUSIONS: Serum leptin levels may be predictive of IVF pregnancy outcome with the effect on intraovarian progesterone/estradiol ratio during the follicular phase. Progesterone 108-120 leptin Homo sapiens 19-25 11527883-1 2001 BACKGROUND: Previous studies have alluded to a role for both oestradiol and progesterone in the secretion of leptin from fat cells in the human, although direct evidence has yet to be obtained. Progesterone 76-88 leptin Homo sapiens 109-115 11527883-2 2001 The study aim was to assess serum leptin concentrations in normally cycling women receiving exogenous oestradiol and progesterone. Progesterone 117-129 leptin Homo sapiens 34-40 11527883-11 2001 In the oestradiol+progesterone cycles, leptin concentrations correlated significantly with oestradiol and progesterone concentrations, but not with FSH and LH concentrations. Progesterone 18-30 leptin Homo sapiens 39-45 11527883-12 2001 CONCLUSIONS: These results show, for the first time, that leptin secretion can be stimulated in women by the administration of oestradiol plus progesterone. Progesterone 143-155 leptin Homo sapiens 58-64 11081675-9 2000 Basal and FSH (10 and 30 ng/ml) stimulated progesterone production was significantly inhibited by leptin 20 ng/ml, whereas leptin 100 ng/ml significantly reduced basal but not FSH stimulated progesterone production. Progesterone 43-55 leptin Homo sapiens 98-104 11081675-9 2000 Basal and FSH (10 and 30 ng/ml) stimulated progesterone production was significantly inhibited by leptin 20 ng/ml, whereas leptin 100 ng/ml significantly reduced basal but not FSH stimulated progesterone production. Progesterone 191-203 leptin Homo sapiens 123-129 11081675-11 2000 CONCLUSION: These results suggest that leptin acts directly to inhibit basal and FSH stimulated estradiol and progesterone production in cultured human granulosa cells. Progesterone 110-122 leptin Homo sapiens 39-45 11056138-0 2000 Treatment of normal women with oestradiol plus progesterone prevents the decrease of leptin concentrations induced by ovariectomy. Progesterone 47-59 leptin Homo sapiens 85-91 11056138-6 2000 Body mass index (BMI) was the most important variable accounting for the changes in leptin values post-operatively, but in the oestradiol plus progesterone group progesterone correlated significantly with leptin independently of BMI. Progesterone 143-155 leptin Homo sapiens 205-211 11056138-6 2000 Body mass index (BMI) was the most important variable accounting for the changes in leptin values post-operatively, but in the oestradiol plus progesterone group progesterone correlated significantly with leptin independently of BMI. Progesterone 162-174 leptin Homo sapiens 205-211 9302379-6 1997 RESULTS: In spontaneously cycling women, changes in circulating leptin levels were associated with menstrual phase (P < 0.001) and correlated with progesterone levels (P < 0.05). Progesterone 150-162 leptin Homo sapiens 64-70 10357956-0 1999 Leptin inhibits gonadotrophin-stimulated granulosa cell progesterone production by antagonizing insulin action. Progesterone 56-68 leptin Homo sapiens 0-6 10357956-2 1999 This study was designed to determine whether leptin modulates basal, gonadotrophin-, and insulin-stimulated progesterone production by human luteinized granulosa cells (GC). Progesterone 108-120 leptin Homo sapiens 45-51 10357956-5 1999 Leptin time- and dose-dependently inhibited (P < 0.05) HCG-stimulated progesterone production by human luteinized GC, but did not alter basal steroidogenesis. Progesterone 73-85 leptin Homo sapiens 0-6 10357956-6 1999 Moreover, the inhibitory effect of leptin on gonadotrophin-stimulated progesterone production was only manifested in the presence of insulin. Progesterone 70-82 leptin Homo sapiens 35-41 10357956-8 1999 We conclude that leptin inhibits gonadotrophin-stimulated GC progesterone production apparently by antagonizing insulin action. Progesterone 61-73 leptin Homo sapiens 17-23 10603707-0 1999 Changes of circulating leptin levels during normal menstrual cycle: relationship to estradiol and progesterone. Progesterone 98-110 leptin Homo sapiens 23-29 10221218-6 1999 Leptin values before and after the operation showed significant positive correlations with body mass index (BMI), oestradiol and progesterone. Progesterone 129-141 leptin Homo sapiens 0-6 10221218-9 1999 Although BMI seems to be the predominant factor, it is also suggested that oestradiol and progesterone may participate in the control of leptin production during the human menstrual cycle. Progesterone 90-102 leptin Homo sapiens 137-143 9863330-18 1998 It was shown that leptin peak is in the luteal phase of the cycle and that correlates to the maximal progesterone level. Progesterone 101-113 leptin Homo sapiens 18-24 9626154-12 1998 In conclusion, leptin secretion from omental adipose tissue in vitro 1) is significantly higher in samples from women than in samples from men, 2) is stimulated by dexamethasone and estradiol in women but not in men, 3) is not modified by progesterone or estrone in both sexes, and 4) is inhibited by forskolin in both genders. Progesterone 239-251 leptin Homo sapiens 15-21 9302379-7 1997 Peak leptin concentrations were recorded during the luteal phase (P < 0.01), coincident with maximal progesterone levels (P < 0.05). Progesterone 104-116 leptin Homo sapiens 5-11