PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21239614-1 2011 We previously showed that progesterone (P4) inhibited the proliferation of human umbilical vein endothelial cells (HUVECs) through a p53-dependent pathway. Progesterone 26-38 tumor protein p53 Homo sapiens 133-136 19565011-0 2005 Progesterone inhibition of MDM2 p90 protein in MCF-7 human breast cancer cell line is dependent on p53 levels. Progesterone 0-12 tumor protein p53 Homo sapiens 99-102 18850315-0 2008 Progesterone inhibits human endothelial cell proliferation through a p53-dependent pathway. Progesterone 0-12 tumor protein p53 Homo sapiens 69-72 18850315-6 2008 Transfection of HUVEC with dominant negative p53 cDNA prevented the progesterone-induced increases in p21 and p27 promoter activity and protein level, decreases in thymidine incorporation, and capillary-like tube formation. Progesterone 68-80 tumor protein p53 Homo sapiens 45-48 17595754-8 2007 There was a association between the absence of p53 and high serum progesterone (p = 0.046). Progesterone 66-78 tumor protein p53 Homo sapiens 47-50 19565011-3 2005 We have recently shown that growth inhibition of MCF-7 human breast cancer cells by progesterone is associated with P53 down-regulation. Progesterone 84-96 tumor protein p53 Homo sapiens 116-119 19565011-7 2005 The inhibition of MDM2 p90 protein by progesterone was abrogated in MCF-7 cells transfected with a P53 expressing vector. Progesterone 38-50 tumor protein p53 Homo sapiens 99-102 19565011-10 2005 The data indicate that expression of MDM2 p90 is regulated through a P53-dependent pathway in response to progesterone. Progesterone 106-118 tumor protein p53 Homo sapiens 69-72 11911261-2 2001 In vitro study using a breast cancer cell line, T47D, demonstrated an increase in p53 gene expression and induction of apoptosis by the administration of progesterone. Progesterone 154-166 tumor protein p53 Homo sapiens 82-85 12615724-5 2003 However, in contrast to p53 wild-type epithelium, estrogen and progesterone, singly or in combination, strongly enhance tumorigenesis in p53-null mammary epithelium. Progesterone 63-75 tumor protein p53 Homo sapiens 137-140 15331571-11 2004 These data indicate that p53 plays a key role in luteinization of the primate ovarian follicle though the regulation of steroidogenic enzymes leading to progesterone synthesis. Progesterone 153-165 tumor protein p53 Homo sapiens 25-28 15053067-4 2004 RESULTS: We observed 14 cases (46.6%) of bcl-2 and four cases (13.3%) of p53 positivity; p53 expression showed an opposite correlation to bcl-2 staining, estrogen and progesterone. Progesterone 167-179 tumor protein p53 Homo sapiens 89-92 14529565-0 2003 Overexpression of wild-type p53 gene renders MCF-7 breast cancer cells more sensitive to the antiproliferative effect of progesterone. Progesterone 121-133 tumor protein p53 Homo sapiens 28-31 14529565-2 2003 Because the tumor suppressor protein p53 plays a central role in normal cell growth and in tumor suppression, we have examined the effect of progesterone on the levels of this protein in MCF-7 cells. Progesterone 141-153 tumor protein p53 Homo sapiens 37-40 14529565-7 2003 We show here that progesterone significantly enhances growth inhibition and apoptosis in MCF-7 cells overexpressing p53, but not in cells transfected with the control vector. Progesterone 18-30 tumor protein p53 Homo sapiens 116-119 14529565-8 2003 These data suggest that re-establishing p53 function in MCF-7 breast cancer cells renders them more sensitive to the growth inhibitory effect of progesterone. Progesterone 145-157 tumor protein p53 Homo sapiens 40-43 30325501-6 2019 Furthermore, combined treatment with progesterone plus mifepristone (PG+MIFE) gave an enhanced anti-proliferative effect in comparison with hydrocortisone plus mifepristone (HC+MIFE) by significantly reducing markers of proliferation (BrdU+ and Ki67 expression) and tumor suppressors (PTEN, TP53), and increasing the percentage of pro-apoptotic cells. Progesterone 37-49 tumor protein p53 Homo sapiens 291-295 9846203-0 1998 Progesterone inhibits growth and induces apoptosis in breast cancer cells: inverse effects on Bcl-2 and p53. Progesterone 0-12 tumor protein p53 Homo sapiens 104-107 34539974-11 2021 Progesterone replacement therapy induced a significant increase in MnSOD, P53, sestrin 2 (SENS2), and TERF2 mRNA expression when compared to basal conditions. Progesterone 0-12 tumor protein p53 Homo sapiens 74-77 31558785-0 2020 Natural history of ovarian high-grade serous carcinoma from time effects of ovulation inhibition and progesterone clearance of p53-defective lesions. Progesterone 101-113 tumor protein p53 Homo sapiens 127-130 31558785-5 2020 In accordance with the proposed cleansing effect of progesterone from studies on oral contraceptive use or term pregnancy, a recent study indicated that the p53-null tubal epithelial cells are selectively cleared by progesterone depending on its progesterone receptor. Progesterone 52-64 tumor protein p53 Homo sapiens 157-160 31558785-5 2020 In accordance with the proposed cleansing effect of progesterone from studies on oral contraceptive use or term pregnancy, a recent study indicated that the p53-null tubal epithelial cells are selectively cleared by progesterone depending on its progesterone receptor. Progesterone 216-228 tumor protein p53 Homo sapiens 157-160 31807178-12 2019 The 11 hub genes were primarily enriched in the cell cycle, oocyte meiosis, progesterone-mediated oocyte maturation, the p53 signaling pathway and viral carcinogenesis. Progesterone 76-88 tumor protein p53 Homo sapiens 121-124 11500921-9 2001 The level of the p53 mRNA reached its maximum at 12 h and decreased after 24 h of incubation with progesterone. Progesterone 98-110 tumor protein p53 Homo sapiens 17-20 11053243-0 2000 Progesterone facilitates chromosome instability (aneuploidy) in p53 null normal mammary epithelial cells. Progesterone 0-12 tumor protein p53 Homo sapiens 64-67 9149021-0 1997 Progesterone induces apoptosis and up-regulation of p53 expression in human ovarian carcinoma cell lines. Progesterone 0-12 tumor protein p53 Homo sapiens 52-55 7737366-5 1995 Progesterone production in such cells treated with cAMP was significantly higher at 32 degrees C than at 37.5 degrees C, suggesting that wild-type p53 can also enhance granulosa cell differentiation. Progesterone 0-12 tumor protein p53 Homo sapiens 147-150 30145226-1 2019 We previously demonstrated that progesterone (P4) up-regulated p53 expression, which in turn increased p21 and p27 expression, and finally resulted in proliferation inhibition in human umbilical vein endothelial cells (HUVEC). Progesterone 32-44 tumor protein p53 Homo sapiens 63-66 29360968-8 2018 Using the p53-specific pharmacological inhibitor (pifithrin-alpha) and siRNA could partially attenuate PPV-induced Bax upregulation, caspase-3 activation, apoptosis, and the reduction of progesterone production in primary porcine SLCs. Progesterone 187-199 tumor protein p53 Homo sapiens 10-13 25113166-3 2014 By examining the interactions of estradiol (E2) and progesterone (P4) in women, we propose that changes in physiologic reproductive hormone templates of exposure and timing can affect fertility and even cancer through the silencing or amplification of gene products; such as P53 and Bcl-2 in women. Progesterone 52-64 tumor protein p53 Homo sapiens 275-278 29185755-3 2018 Furthermore, the expression of p27, a crucial cell cycle control protein, was regulated by binding of progesterone on progesterone receptor B, thus leading to antiproliferative signaling via multiple signaling pathways including p53, PTEN, and antioxidant systems. Progesterone 102-114 tumor protein p53 Homo sapiens 229-232 25754581-1 2015 We previously showed that progesterone (P4) could inhibit the proliferation of human umbilical venous endothelial cells (HUVECs) through the p53-dependent pathway. Progesterone 26-38 tumor protein p53 Homo sapiens 141-144 25353185-0 2015 Progesterone receptor-NFkappaB complex formation is required for progesterone-induced NFkappaB nuclear translocation and binding onto the p53 promoter. Progesterone 65-77 tumor protein p53 Homo sapiens 138-141 28297660-3 2017 Because ovulation is frequent and HGSOC is rare, we hypothesized that luteal-phase progesterone (P4) could eliminate p53-defective FT cells. Progesterone 83-95 tumor protein p53 Homo sapiens 117-120