PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33826978-9 2021 In granulosa cells isolated from spring and fall collected ovaries, IGF1 plus FSH inhibited (P < 0.05) progesterone production. Progesterone 103-115 insulin like growth factor 1 Homo sapiens 68-72 33826978-10 2021 Melatonin increased (P < 0.05) FSH plus IGF1-induced cell proliferation and amplified (P < 0.05) the FSH plus IGF1-induced inhibition of progesterone production. Progesterone 137-149 insulin like growth factor 1 Homo sapiens 110-114 25385439-2 2014 As insulin-like growth factor I (IGF-I) underlies both estrogen and progesterone actions and has other direct effects on mammary development and carcinogenesis, we hypothesized that IGF-I inhibition might provide a novel approach for breast cancer chemoprevention. Progesterone 68-80 insulin like growth factor 1 Homo sapiens 3-31 33561006-6 2021 Estrogen and progesterone led to the increase of IGF-1 in DSCs through up-regulating the expression of WISP2. Progesterone 13-25 insulin like growth factor 1 Homo sapiens 49-54 33561006-8 2021 These data suggest that estrogen and progesterone stimulate the growth of DSCs and impair the cytotoxicity of dNK possibly by the WISP2/IGF-1 signaling pathway. Progesterone 37-49 insulin like growth factor 1 Homo sapiens 136-141 25385439-2 2014 As insulin-like growth factor I (IGF-I) underlies both estrogen and progesterone actions and has other direct effects on mammary development and carcinogenesis, we hypothesized that IGF-I inhibition might provide a novel approach for breast cancer chemoprevention. Progesterone 68-80 insulin like growth factor 1 Homo sapiens 33-38 25385439-2 2014 As insulin-like growth factor I (IGF-I) underlies both estrogen and progesterone actions and has other direct effects on mammary development and carcinogenesis, we hypothesized that IGF-I inhibition might provide a novel approach for breast cancer chemoprevention. Progesterone 68-80 insulin like growth factor 1 Homo sapiens 182-187 21448845-0 2011 Differential roles of MAPK-Erk1/2 and MAPK-p38 in insulin or insulin-like growth factor-I (IGF-I) signaling pathways for progesterone production in human ovarian cells. Progesterone 121-133 insulin like growth factor 1 Homo sapiens 61-89 24345238-6 2014 The results of our in vitro study indicate the T-2 and HT-2 toxins combined with IGF-I could modify progesterone secretion by porcine ovarian granulosa cells and potentially regulate process of steroidogenesis in the ovaries. Progesterone 100-112 insulin like growth factor 1 Homo sapiens 81-86 22447628-7 2012 rhChem (10 or 100 ng/ml) significantly decreased insulin-like growth factor-1 (IGF-1) (10(-8) M)-induced secretion of progesterone and estradiol (as determined by radioimmunoassay) but did not affect basal-or FSH (10(-8) M)-induced steroid secretion in hGCs and KGN cells. Progesterone 118-130 insulin like growth factor 1 Homo sapiens 49-77 22447628-7 2012 rhChem (10 or 100 ng/ml) significantly decreased insulin-like growth factor-1 (IGF-1) (10(-8) M)-induced secretion of progesterone and estradiol (as determined by radioimmunoassay) but did not affect basal-or FSH (10(-8) M)-induced steroid secretion in hGCs and KGN cells. Progesterone 118-130 insulin like growth factor 1 Homo sapiens 79-84 21448845-13 2011 Both MAPK-Erk1/2 and MAPK-p38 participate in IGF-I-induced signaling pathways for progesterone production, while insulin-induced progesterone production requires MAPK-p38, but not MAPK-Erk1/2. Progesterone 82-94 insulin like growth factor 1 Homo sapiens 45-50 21448845-0 2011 Differential roles of MAPK-Erk1/2 and MAPK-p38 in insulin or insulin-like growth factor-I (IGF-I) signaling pathways for progesterone production in human ovarian cells. Progesterone 121-133 insulin like growth factor 1 Homo sapiens 91-96 21448845-3 2011 We investigated the roles of MAPK-Erk1/2 and MAPK-p38 in insulin and IGF-I signaling pathways for progesterone production in human ovarian cells. Progesterone 98-110 insulin like growth factor 1 Homo sapiens 69-74 21448845-10 2011 Insulin or IGF-I alone stimulated progesterone production by 40-60% (p<0.001). Progesterone 34-46 insulin like growth factor 1 Homo sapiens 11-16 21448845-12 2011 Either PD98059 or SB203580 abolished IGF-I-induced progesterone production. Progesterone 51-63 insulin like growth factor 1 Homo sapiens 37-42 20132087-1 2010 OBJECTIVE: Placenta human choriocarcinoma JEG-3 cells were used to study the possibility that pituitary growth hormone (GH) and insulin-like growth factor type I (IGF-I) act on first trimester of pregnancy progesterone (P4) and human chorionic gonadotropin (hCG) secretion, cell proliferation and apoptosis. Progesterone 206-218 insulin like growth factor 1 Homo sapiens 128-168 16442609-10 2006 In conclusion, ovariectomy of bitches in the mid-luteal phase stops progesterone-induced GH release from the mammary gland, as evidenced by the lowering of basal plasma GH levels, the recurrence of GH pulsatility, and the lowering of circulating IGF-I levels. Progesterone 68-80 insulin like growth factor 1 Homo sapiens 246-251 17953960-0 2008 Effects of growth hormone and insulin-like growth factor 1 on progesterone production in human luteinized granulosa cells. Progesterone 62-74 insulin like growth factor 1 Homo sapiens 30-58 17953960-8 2008 Effects of GH and insulin-like growth factor 1 (IGF-1) on progesterone and estradiol production were examined in the presence or absence of human chorionic gonadotropin (hCG) in human luteinized granulosa cells. Progesterone 58-70 insulin like growth factor 1 Homo sapiens 48-53 18325000-9 2008 In conclusion, these data show a positive relationship between peripheral IGF-1 and progesterone concentrations in vivo during the early luteal phase. Progesterone 84-96 insulin like growth factor 1 Homo sapiens 74-79 17010558-7 2007 To determine whether adiponectin is involved in the ovarian steroidogenesis, LH (100 ng/ml)-, FSH (100 ng/ml)- and IGF-1 (100 ng/ml)-induced progesterone production was measured in absence or presence of human recombinant adiponectin (10 microg/ml) for 36 h in cultured granulosa cells from F1, F2 and mixed F3 and F4 follicles. Progesterone 141-153 insulin like growth factor 1 Homo sapiens 115-120 19499404-2 2009 The present study was conducted to elucidate whether progesterone affects IGF-I mRNA through progesterone receptor B(PRB) mRNA in leiomyoma. Progesterone 53-65 insulin like growth factor 1 Homo sapiens 74-79 19499404-6 2009 CONCLUSION: The progesterone may down-regulate IGF-I expression through PRB, and PRA appears to inhibit this function of progesterone by inhibiting the transcription of PRB; thus, the action of progesterone on leiomyoma growth may depend on different ratios of PRA and PRB. Progesterone 16-28 insulin like growth factor 1 Homo sapiens 47-52 17492948-3 2007 This secondary analysis, based on a large randomized trial, aimed to estimate the effect of the route of administration of 17beta-oestradiol in combined hormone replacement therapy with progesterone on IGF-1 and IGFBP-3 levels. Progesterone 186-198 insulin like growth factor 1 Homo sapiens 202-207 16213990-8 2005 In addition, free IGF-I concentrations in FFL were positively correlated (P < 0.01) with FFL estradiol, progesterone, androstenedione, estradiol:progesterone ratio, total IGF-I and total IGF-II. Progesterone 107-119 insulin like growth factor 1 Homo sapiens 18-23 16794358-5 2006 The intrafollicular levels of IGF-I were positively correlated with those of progesterone. Progesterone 77-89 insulin like growth factor 1 Homo sapiens 30-35 16213990-8 2005 In addition, free IGF-I concentrations in FFL were positively correlated (P < 0.01) with FFL estradiol, progesterone, androstenedione, estradiol:progesterone ratio, total IGF-I and total IGF-II. Progesterone 148-160 insulin like growth factor 1 Homo sapiens 18-23 16244494-2 2005 METHODS: We studied the action of leptin (0, 1, 10, or 100 ng/ml) and immunoneutralization of IGF-I using specific antiserum (0.1%) on the release of progesterone (P), estradiol (E), oxytocin (OT), IGF-I, IGFBP-3, and prostaglandins F (PGF) by these cells using radioimmunoassay/immunoradiometric assay. Progesterone 150-162 insulin like growth factor 1 Homo sapiens 94-99 15809018-2 2005 The aim of the present study was to investigate direct effects of estrogen (E2) or progesterone (P4) given separately vs. estrogen+progesterone on local IGF-I, IGFBP-3 and IGFBP-2 secretion. Progesterone 83-95 insulin like growth factor 1 Homo sapiens 153-158 15809018-5 2005 In hormone-dependent and hormone-independent tissues, treatment with estrogen+progesterone increased IGF-I and IGFBP-2 secretion with concomitant decrease in IGFBP-3, in the same manner as E2 or P4 given alone. Progesterone 78-90 insulin like growth factor 1 Homo sapiens 101-106 16244494-2 2005 METHODS: We studied the action of leptin (0, 1, 10, or 100 ng/ml) and immunoneutralization of IGF-I using specific antiserum (0.1%) on the release of progesterone (P), estradiol (E), oxytocin (OT), IGF-I, IGFBP-3, and prostaglandins F (PGF) by these cells using radioimmunoassay/immunoradiometric assay. Progesterone 150-162 insulin like growth factor 1 Homo sapiens 198-203 15140868-6 2004 Since it is now evident that EGF and IGF-I act as local factors which stimulate leiomyoma growth, these findings suggest that progesterone may have dual actions, stimulatory and inhibitory, on leiomyoma cell growth and survival, depending on the local growth factor conditions around each leiomyoma. Progesterone 126-138 insulin like growth factor 1 Homo sapiens 37-42 15147234-10 2004 Moreover, it acted synergistically with IGF-I and GH causing further stimulation of progesterone secretion. Progesterone 84-96 insulin like growth factor 1 Homo sapiens 40-45 15033949-2 2004 The present study was conducted to elucidate whether progesterone affects IGF-I and its receptor expression in cultured leiomyoma cells. Progesterone 53-65 insulin like growth factor 1 Homo sapiens 74-79 15033949-9 2004 CONCLUSIONS: The present study provided evidence for the first time that progesterone down-regulates IGF-I mRNA and protein expression in cultured leiomyoma cells without affecting IGF-I receptor mRNA expression. Progesterone 73-85 insulin like growth factor 1 Homo sapiens 101-106 12908822-5 2003 The results showed that the extracellular levels of free IGF-1 locally in the breast were doubled in the luteal phase, when estradiol and progesterone levels were elevated, compared with the follicular phase. Progesterone 138-150 insulin like growth factor 1 Homo sapiens 57-62 14674122-0 2003 The impact of progesterone on simultaneous, local secretion of IGFBP-3 and IGF-I [IGFBP-3/IGF-I index] by human malignant and non-malignant breast explants depends on tissue steroid receptor phenotype. Progesterone 14-26 insulin like growth factor 1 Homo sapiens 75-80 14674122-0 2003 The impact of progesterone on simultaneous, local secretion of IGFBP-3 and IGF-I [IGFBP-3/IGF-I index] by human malignant and non-malignant breast explants depends on tissue steroid receptor phenotype. Progesterone 14-26 insulin like growth factor 1 Homo sapiens 90-95 12843192-18 2003 In the presence of 1 micro M PD98059, IGF-I-induced stimulation of progesterone production was inhibited by 96% (P < 0.001). Progesterone 67-79 insulin like growth factor 1 Homo sapiens 38-43 12361468-4 2002 The results showed that addition of IGF-I stimulated progesterone production (150%, P < 0.01), oestradiol production (65%, P < 0.05) and bcl-2 gene expression (approximately 200%, P < 0.05), but decreased apoptosis (P < 0.05). Progesterone 53-65 insulin like growth factor 1 Homo sapiens 36-41 12843192-0 2003 The role of mitogen-activated protein kinase in insulin and insulin-like growth factor I (IGF-I) signaling cascades for progesterone and IGF-binding protein-1 production in human granulosa cells. Progesterone 120-132 insulin like growth factor 1 Homo sapiens 60-88 12843192-0 2003 The role of mitogen-activated protein kinase in insulin and insulin-like growth factor I (IGF-I) signaling cascades for progesterone and IGF-binding protein-1 production in human granulosa cells. Progesterone 120-132 insulin like growth factor 1 Homo sapiens 90-95 12843192-6 2003 We now examined whether activation of MAPK is necessary to mediate insulin-induced or IGF-I-induced stimulation of progesterone or inhibition of IGFBP-1 production in human granulosa cells. Progesterone 115-127 insulin like growth factor 1 Homo sapiens 86-91 12843192-16 2003 Progesterone production in granulosa cells was stimulated by IGF-I to 130% of the control value (P < 0.001), whereas IGFBP-1 production was inhibited to 44% of the control value (P < 0.001). Progesterone 0-12 insulin like growth factor 1 Homo sapiens 61-66 11953083-1 2002 OBJECTIVE: To assess the effects of leptin on follicle-stimulating hormone (FSH) and insulin-like growth factor-I (IGF-I) induced production of estradiol (E(2))-17beta and progesterone (P) in cultured human luteinized granulosa cell (GC). Progesterone 172-184 insulin like growth factor 1 Homo sapiens 85-113 12396561-11 2002 Taken together, the tested synthetic progestins widely used as oral contraceptives and in hormone replacement therapy were less potent than progesterone in inducing secretion of proliferation-promoting agents such as hGH and IGF-I in ER-containing breast tissue. Progesterone 140-152 insulin like growth factor 1 Homo sapiens 225-230 11953083-1 2002 OBJECTIVE: To assess the effects of leptin on follicle-stimulating hormone (FSH) and insulin-like growth factor-I (IGF-I) induced production of estradiol (E(2))-17beta and progesterone (P) in cultured human luteinized granulosa cell (GC). Progesterone 172-184 insulin like growth factor 1 Homo sapiens 115-120 11560097-1 2001 The aim of the study was to evaluate the potential of human breast cancer tissue to secrete growth hormone (GH), insulin-like growth factor I (IGF-I) and prolactin in response to 10(-7) M progesterone stimulation. Progesterone 188-200 insulin like growth factor 1 Homo sapiens 113-141 11560097-1 2001 The aim of the study was to evaluate the potential of human breast cancer tissue to secrete growth hormone (GH), insulin-like growth factor I (IGF-I) and prolactin in response to 10(-7) M progesterone stimulation. Progesterone 188-200 insulin like growth factor 1 Homo sapiens 143-148 11560097-3 2001 Our results show distinct differences in cultured breast cancer tissue responses to progesterone stimulation with regard to secretion of proliferative agents such as GH, IGF-I and prolactin. Progesterone 84-96 insulin like growth factor 1 Homo sapiens 170-175 11560097-6 2001 This study provides evidence for the first time that in PR(+) breast cancer tissue, progesterone may increase GH, prolactin and IGF-I secretion in both malignant and surrounding non-malignant tissue. Progesterone 84-96 insulin like growth factor 1 Homo sapiens 128-133 11357060-5 2001 It was observed that GH, IGF-I, estradiol, LH and oxytocin alter the progesterone, oxytocin, IGF-I and IGFBP-3 release by porcine ovarian granulosa cells. Progesterone 69-81 insulin like growth factor 1 Homo sapiens 25-30 9886824-1 1999 Insulin-like growth factor I (IGF-I) and the gonadotropin, FSH, can synergize to stimulate progesterone production in primary cultures of maturing granulosa cells. Progesterone 91-103 insulin like growth factor 1 Homo sapiens 0-28 11089528-14 2000 Together, these investigations document a significant role for insulin or IGF-I in enhancing LH-stimulated progesterone and cAMP biosynthesis and endogenous StAR message and protein accumulation and in augmenting cAMP-PKA-dependent transcriptional activation of the exogenous StAR promoter. Progesterone 107-119 insulin like growth factor 1 Homo sapiens 74-79 10729039-13 1999 Correlation coefficients between IGF-I and progesterone concentrations in monensin plus progesterone group adults were -0.715 (P<0.02) and -0.516 (P<0.01), respectively across all treatments. Progesterone 43-55 insulin like growth factor 1 Homo sapiens 33-38 9886819-1 1999 Insulin-like growth factor I (IGF-I) and the gonadotropin, FSH, can synergize to stimulate progesterone production in primary cultures of maturing human, rat, and pig granulosa cells. Progesterone 91-103 insulin like growth factor 1 Homo sapiens 0-28 9886819-1 1999 Insulin-like growth factor I (IGF-I) and the gonadotropin, FSH, can synergize to stimulate progesterone production in primary cultures of maturing human, rat, and pig granulosa cells. Progesterone 91-103 insulin like growth factor 1 Homo sapiens 30-35 10611187-10 2000 In conclusion, up-regulation of IGFBP-1 collaboratively with down-regulation of IGF-I may account for the protective effect of progesterone in HRT on the endometrium. Progesterone 127-139 insulin like growth factor 1 Homo sapiens 80-85 9886824-1 1999 Insulin-like growth factor I (IGF-I) and the gonadotropin, FSH, can synergize to stimulate progesterone production in primary cultures of maturing granulosa cells. Progesterone 91-103 insulin like growth factor 1 Homo sapiens 30-35 8954026-4 1996 The mean age-adjusted IGF-I level was highest in the 415 women who reported never or past HRT use (126.8 micrograms/L), lowest in the 128 women who reported using estrogen alone (99.3 micrograms/L), and intermediate in the 115 women who reported using combination estrogen and progesterone (112.4 micrograms/L). Progesterone 277-289 insulin like growth factor 1 Homo sapiens 22-27 9654167-3 1998 RESULTS: IGF-I alone resulted in a significant dose-dependent increase in medium estradiol (E2) (p<0.05) and progesterone (P) (p<0.001) and suppression of IGF-binding protein-1 (IGFBP-1) (p<0.001), without any increase in [3H]-thymidine incorporation (P=0.10). Progesterone 112-124 insulin like growth factor 1 Homo sapiens 9-14 8880428-7 1996 In addition, serum IGF-I during the first 10 d after estrus was not correlated to luteal weight and only weakly correlated (r = .3) with luteal progesterone content. Progesterone 144-156 insulin like growth factor 1 Homo sapiens 19-24 8728009-9 1996 Combinations (10 ng/mL each hormone) of GH and IGF-I or PRL and IGF-I increased progesterone secretion by LLC compared with control, GH, PRL, or IGF-I alone (P < .05). Progesterone 80-92 insulin like growth factor 1 Homo sapiens 47-52 8690108-0 1996 Insulin-like growth factor (IGF)-I and IGF-II stimulate progesterone production by human luteal cells: role of IGF-I as mediator of growth hormone action. Progesterone 56-68 insulin like growth factor 1 Homo sapiens 0-34 8690108-0 1996 Insulin-like growth factor (IGF)-I and IGF-II stimulate progesterone production by human luteal cells: role of IGF-I as mediator of growth hormone action. Progesterone 56-68 insulin like growth factor 1 Homo sapiens 39-44 8908523-0 1996 Characterization of receptors for insulin-like growth factor type I on cultured human endometrial stromal cells: downregulation by progesterone. Progesterone 131-143 insulin like growth factor 1 Homo sapiens 34-67 8728009-6 1996 Growth hormone, PRL, and IGF-I increased (P < .05; 100 ng/mL dose) concentrations of progesterone in media of LLC. Progesterone 88-100 insulin like growth factor 1 Homo sapiens 25-30 8728009-9 1996 Combinations (10 ng/mL each hormone) of GH and IGF-I or PRL and IGF-I increased progesterone secretion by LLC compared with control, GH, PRL, or IGF-I alone (P < .05). Progesterone 80-92 insulin like growth factor 1 Homo sapiens 64-69 8728009-9 1996 Combinations (10 ng/mL each hormone) of GH and IGF-I or PRL and IGF-I increased progesterone secretion by LLC compared with control, GH, PRL, or IGF-I alone (P < .05). Progesterone 80-92 insulin like growth factor 1 Homo sapiens 64-69 8728009-12 1996 Both GH and PRL are synergistic with IGF-I for increased progesterone secretion. Progesterone 57-69 insulin like growth factor 1 Homo sapiens 37-42 7964301-6 1994 IGF-I mainly enhanced the proliferation of granulosa cells from small follicles but it strongly increased progesterone secretion and P450scc expression in granulosa cells from large follicles, in synergy with FSH. Progesterone 106-118 insulin like growth factor 1 Homo sapiens 0-5 7525255-14 1994 In contrast, treatment with IGF-I caused a small increase in estrogen but decreased progesterone production. Progesterone 84-96 insulin like growth factor 1 Homo sapiens 28-33 8759407-6 1996 In synergism with FSH, IGF-1 stimulates aromatase activity, enhances proteoglycan biosynthesis, increases progesterone action. Progesterone 106-118 insulin like growth factor 1 Homo sapiens 23-28 7556882-0 1995 Growth hormone amplifies insulin-like growth factor I induced progesterone accumulation and P450scc mRNA expression. Progesterone 62-74 insulin like growth factor 1 Homo sapiens 25-53 7556882-1 1995 The interaction of growth hormone (GH) and insulin-like growth factor I (IGF-I) in the acquisition of progesterone biosynthetic capacity were examined in cultured porcine granulosa cells. Progesterone 102-114 insulin like growth factor 1 Homo sapiens 43-71 7556882-1 1995 The interaction of growth hormone (GH) and insulin-like growth factor I (IGF-I) in the acquisition of progesterone biosynthetic capacity were examined in cultured porcine granulosa cells. Progesterone 102-114 insulin like growth factor 1 Homo sapiens 73-78 7556882-3 1995 However, concurrent treatment with GH produced a 4.1-fold increase (539 versus 2214 ng/culture) in the IGF-I-stimulated accumulation of progesterone. Progesterone 136-148 insulin like growth factor 1 Homo sapiens 103-108 7964301-12 1994 Unexpectedly, heavily stained cells in mitosis were observed in IGF-I-stimulated cells from large follicles after 96 h of culture, suggesting that dividing cells might also produce progesterone. Progesterone 181-193 insulin like growth factor 1 Homo sapiens 64-69 7522266-11 1994 Similarly IGFBP-1, -2, and -4 are detected in medium conditioned by term decidua cells by Western ligand blot in which release of IGFBP-1 and -4 are diminished by IGF-I and all three IGFBPs are increased by progesterone. Progesterone 207-219 insulin like growth factor 1 Homo sapiens 163-168 8020171-8 1994 IGF-I may play a role in regulation of ovulation induction and luteinisation as IGF-I and hCG act synergistically in increasing progesterone secretion of granulosa cells of natural cycles in vitro and are known to stimulate each other"s receptor expression. Progesterone 128-140 insulin like growth factor 1 Homo sapiens 0-5 8020171-8 1994 IGF-I may play a role in regulation of ovulation induction and luteinisation as IGF-I and hCG act synergistically in increasing progesterone secretion of granulosa cells of natural cycles in vitro and are known to stimulate each other"s receptor expression. Progesterone 128-140 insulin like growth factor 1 Homo sapiens 80-85 1813068-3 1991 Addition of an anti-insulin-like growth factor-I (IGF-I) antibody inhibited E2- and Pg-stimulated growth, while PRL action was not affected. Progesterone 84-86 insulin like growth factor 1 Homo sapiens 15-48 8288742-11 1993 After 4 days, LH and IGF-I stimulated progesterone levels by 279 +/- 52% and 264 +/- 37% (mean +/- SEM, n = 5) respectively. Progesterone 38-50 insulin like growth factor 1 Homo sapiens 21-26 1284489-4 1992 The progesterone response to IGF-I was inhibited by IGFBPs 1 and 3 but there was no effect on FSH-stimulated progesterone production. Progesterone 4-16 insulin like growth factor 1 Homo sapiens 29-34 8399837-3 1993 The present studies were conducted to evaluate the actions of FSH and of the growth factors epidermal growth factor (EGF), transforming growth factor alpha (TGF alpha), and insulin-like growth factor I (IGF-I) in regulating levels of P450scc mRNA and initiating progesterone production in cultured granulosa cells from 6- to 8-mm follicles. Progesterone 262-274 insulin like growth factor 1 Homo sapiens 203-208 1587932-2 1992 For this purpose, we compared the ability of normal and PCO granulosa cells to synthesize oestrogen and progesterone in vitro in response to follicle stimulating hormone (FSH) and/or insulin-like growth factor-I (IGF-I). Progesterone 104-116 insulin like growth factor 1 Homo sapiens 183-211 1813068-3 1991 Addition of an anti-insulin-like growth factor-I (IGF-I) antibody inhibited E2- and Pg-stimulated growth, while PRL action was not affected. Progesterone 84-86 insulin like growth factor 1 Homo sapiens 50-55 1910243-4 1991 It was found that in granulosa cells from follicles of natural cycles, FSH as well as IGF-I significantly stimulated progesterone and estradiol production in a majority of the experiments. Progesterone 117-129 insulin like growth factor 1 Homo sapiens 86-91 1806564-6 1991 By comparison, the effects of IGF-I on progesterone production were not marked, being absent in 80% of the follicles tested. Progesterone 39-51 insulin like growth factor 1 Homo sapiens 30-35 1806564-7 1991 However, granulosa cells from healthy follicles co-incubated with IGF-I and FSH or HCG produced more progesterone compared with cells treated with the gonadotrophins alone; this effect of IGF-I was dose dependent (ED50 of IGF-I = 10 ng/ml). Progesterone 101-113 insulin like growth factor 1 Homo sapiens 66-71 1806564-7 1991 However, granulosa cells from healthy follicles co-incubated with IGF-I and FSH or HCG produced more progesterone compared with cells treated with the gonadotrophins alone; this effect of IGF-I was dose dependent (ED50 of IGF-I = 10 ng/ml). Progesterone 101-113 insulin like growth factor 1 Homo sapiens 188-193 1806564-7 1991 However, granulosa cells from healthy follicles co-incubated with IGF-I and FSH or HCG produced more progesterone compared with cells treated with the gonadotrophins alone; this effect of IGF-I was dose dependent (ED50 of IGF-I = 10 ng/ml). Progesterone 101-113 insulin like growth factor 1 Homo sapiens 188-193 2004596-3 1991 IGF-I (human recombinant, 100 ng/ml) was as effective as LH (ovine, 10 ng/ml) in maintaining progesterone accumulation through 4 days of culture. Progesterone 93-105 insulin like growth factor 1 Homo sapiens 0-5 1663878-0 1991 Effects of gonadotropins, insulin and insulin-like growth factor I on ovarian oxytocin and progesterone production. Progesterone 91-103 insulin like growth factor 1 Homo sapiens 38-66 1905506-3 1991 Furthermore, IGF-I alone and in combination with FSH or LH enhanced estradiol and progesterone production. Progesterone 82-94 insulin like growth factor 1 Homo sapiens 13-18 2226329-8 1990 Treatment with pure recombinant human IGF-I (100 ng/ml) significantly increased P450scc mRNA concentrations after 18 h, and maximal stimulation (10- to 20-fold) occurred by 48 h for both P450scc mRNA and progesterone accumulation. Progesterone 204-216 insulin like growth factor 1 Homo sapiens 38-43 2226329-9 1990 The IGF-I dose-response curve studied at 48 h showed a significant increase in P450scc mRNA levels at a minimal IGF-I concentration of 1 ng/ml (although progesterone production was not increased). Progesterone 153-165 insulin like growth factor 1 Homo sapiens 4-9 2226329-3 1990 Since treatment of primary cultures of immature porcine granulosa cells with IGF-I will increase progesterone production as well as the synthesis of immunoprecipitable P450scc enzyme, we examined possible molecular mechanisms subserving these inductive effects of IGF-I. Progesterone 97-109 insulin like growth factor 1 Homo sapiens 77-82 2226329-9 1990 The IGF-I dose-response curve studied at 48 h showed a significant increase in P450scc mRNA levels at a minimal IGF-I concentration of 1 ng/ml (although progesterone production was not increased). Progesterone 153-165 insulin like growth factor 1 Homo sapiens 112-117 2226329-13 1990 Low density lipoprotein alone also did not stimulate P450scc mRNA levels and only slightly increased progesterone accumulation, but acted synergistically with IGF-I to augment P450scc mRNA concentrations and progesterone accumulation. Progesterone 208-220 insulin like growth factor 1 Homo sapiens 159-164 2226329-15 1990 Estradiol cotreatment with IGF-I synergistically enhanced progesterone production, but did not alter IGF-I-stimulated P450scc mRNA concentrations. Progesterone 58-70 insulin like growth factor 1 Homo sapiens 27-32 2172119-7 1990 Progesterone treatment stimulated a significant increase in EGF and IGF-1 receptors in gland cultures. Progesterone 0-12 insulin like growth factor 1 Homo sapiens 68-73 34166505-8 2021 In experiment 3, RSPO1 further increased (P < 0.05) LH plus IGF1-induced progesterone and androstenedione production. Progesterone 73-85 insulin like growth factor 1 Homo sapiens 60-64 2159194-1 1990 The effect of insulin and insulin-like growth factor-1 (IGF-1) on progesterone secretion by porcine granulosa cells and their modulatory effect on follicle-stimulating hormone (FSH)-induced responses were examined. Progesterone 66-78 insulin like growth factor 1 Homo sapiens 56-61 3281962-11 1988 Low density lipoprotein provides the substrate and somatomedin C modulates among other hormones" influences, progesterone production. Progesterone 109-121 insulin like growth factor 1 Homo sapiens 51-64 2551637-3 1989 Incubation of cytotrophoblasts with insulin or IGF-I for 24 h significantly increased the ability of these cells to convert pregnenolone to progesterone by 75.8 +/- 16.5% (+/- SE) and 65.4 +/- 12.7%, respectively. Progesterone 140-152 insulin like growth factor 1 Homo sapiens 47-52 2551637-10 1989 Since pregnant diabetic women manifest peripheral hyperinsulinemia, and IGF-I levels in fetal cord sera from diabetic pregnancies may be elevated, these observations may help explain the elevated serum progesterone levels associated with pregnancy in the diabetic patient. Progesterone 202-214 insulin like growth factor 1 Homo sapiens 72-77 2786804-4 1989 IGF-I increased (P less than 0.05) the basal and hCG-induced secretion of progesterone and androstenedione at the highest doses, but did not affect basal secretion of estradiol or testosterone. Progesterone 74-86 insulin like growth factor 1 Homo sapiens 0-5 2968034-7 1988 Although the maximal effective doses of IGF-I and insulin produced a comparable increment in progesterone secretion and LH/hCG receptor induction, combined treatment with IGF-I and insulin did not prove additive. Progesterone 93-105 insulin like growth factor 1 Homo sapiens 40-45 3732135-1 1986 Estradiol amplified synergistically the dose- and time-dependent stimulatory actions of human somatomedin-C on progesterone biosynthesis by cultured swine granulosa cells. Progesterone 111-123 insulin like growth factor 1 Homo sapiens 94-107 3311719-11 1987 Insulin treatment did not affect P450 SCC activity, whereas IGF-I treatment significantly stimulated P450 SCC activity by 19-36%, as measured by the conversion of 25-hydroxycholesterol to progesterone. Progesterone 188-200 insulin like growth factor 1 Homo sapiens 60-65 3311719-13 1987 Since pregnant diabetic women manifest peripheral hyperinsulinemia, and IGF-I levels in fetal cord sera from diabetic pregnancies are elevated, these observations may help explain the lower serum estrogen and elevated progesterone levels associated with diabetic pregnancy. Progesterone 218-230 insulin like growth factor 1 Homo sapiens 72-77 4040752-1 1985 Isolated swine granulosa cells incubated in chemically defined medium in vitro responded to synthetically pure human somatomedin C/IGF-I in a dose and time-dependent fashion with increased pregnenolone, progesterone and estradiol biosynthesis. Progesterone 203-215 insulin like growth factor 1 Homo sapiens 117-130 3753972-2 1986 Nanomolar concentrations of pure human somatomedin C stimulated biosynthesis of progesterone and 20 alpha-hydroxypregn-4-en-3-one. Progesterone 80-92 insulin like growth factor 1 Homo sapiens 39-52 4040752-1 1985 Isolated swine granulosa cells incubated in chemically defined medium in vitro responded to synthetically pure human somatomedin C/IGF-I in a dose and time-dependent fashion with increased pregnenolone, progesterone and estradiol biosynthesis. Progesterone 203-215 insulin like growth factor 1 Homo sapiens 131-136