PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32365105-9 2020 Progesterone partially blocked thrombin-induced myometrial contractions, which was accompanied by suppression of the thrombin-induced increase of PTGS2 and IL1B mRNA expressions as well as suppression of PAR1 expression. Progesterone 0-12 interleukin 1 beta Homo sapiens 156-160 32792990-6 2020 In subsequent dose response studies, medroxyprogesterone acetate, but not progesterone, at doses of 10-6-10-8 M inhibited interleukin-1beta induced interleukin-8 and matrix metalloproteinase 1 mRNA expression. Progesterone 44-56 interleukin 1 beta Homo sapiens 122-139 29236553-5 2018 lipopolysaccharide co-treatment with progesterone significantly decreased the bacterial endotoxin-induced IL-1beta, TNF-alpha, IL-6, IL-8, and MIP-1alpha secretion. Progesterone 37-49 interleukin 1 beta Homo sapiens 106-114 29239061-0 2018 Progesterone inhibited endoplasmic reticulum stress associated apoptosis induced by interleukin-1beta via the GRP78/PERK/CHOP pathway in BeWo cells. Progesterone 0-12 interleukin 1 beta Homo sapiens 84-101 29239061-10 2018 IL-1beta could induce ERS and associated cell apoptosis by activating the GRP78/PERK/CHOP signal pathway, which could be inhibited by progesterone. Progesterone 134-146 interleukin 1 beta Homo sapiens 0-8 28651331-0 2017 IL-1beta Upregulates StAR and Progesterone Production Through the ERK1/2- and p38-Mediated CREB Signaling Pathways in Human Granulosa-Lutein Cells. Progesterone 30-42 interleukin 1 beta Homo sapiens 0-8 28651331-4 2017 Moreover, IL-1beta activated the phosphorylation of cyclic adenosine monophosphate response element-binding protein (CREB), and knockdown of CREB attenuated the induction of StAR expression and progesterone synthesis by IL-1beta in granulosa-lutein cells. Progesterone 194-206 interleukin 1 beta Homo sapiens 10-18 28651331-5 2017 Furthermore, IL-1beta activated the extracellular signal-regulated kinase (ERK)1/2 and p38 pathways and inhibition of the ERK1/2 and p38 pathways attenuated the IL-1beta-induced phosphorylation of CREB, StAR expression, and progesterone synthesis in granulosa-lutein cells. Progesterone 224-236 interleukin 1 beta Homo sapiens 13-21 28651331-2 2017 However, the exact effect of IL-1beta on progesterone synthesis in granulosa cells and the underlying mechanism remain unclear. Progesterone 41-53 interleukin 1 beta Homo sapiens 29-37 28651331-5 2017 Furthermore, IL-1beta activated the extracellular signal-regulated kinase (ERK)1/2 and p38 pathways and inhibition of the ERK1/2 and p38 pathways attenuated the IL-1beta-induced phosphorylation of CREB, StAR expression, and progesterone synthesis in granulosa-lutein cells. Progesterone 224-236 interleukin 1 beta Homo sapiens 161-169 28651331-6 2017 In conclusion, IL-1beta could upregulate StAR expression and stimulate progesterone biosynthesis through increase in CREB phosphorylation via activating the ERK1/2 and p38 pathways in human granulosa-lutein cells. Progesterone 71-83 interleukin 1 beta Homo sapiens 15-23 28651331-3 2017 By using cultured granulosa-lutein cells collected from women undergoing in vitro fertilization or intracytoplasmic sperm injection, we found that IL-1beta upregulated steroidogenic acute regulatory protein (StAR) expression and progesterone synthesis in granulosa-lutein cells, which was comparable with luteinizing hormone effect and could be abolished by an IL-1 receptor antagonist. Progesterone 229-241 interleukin 1 beta Homo sapiens 147-155 24581581-10 2014 In marginal structural models, IL-1beta, IL-6, IL-8 were associated with lower estradiol and progesterone concentrations. Progesterone 93-105 interleukin 1 beta Homo sapiens 31-39 26803522-7 2016 Meanwhile, a reduction in the serum levels of IL-1beta, MDA and S-100B was noticed in progesterone group 24h after injury (P<0.05, P<0.001 and P<0.05, respectively), and there was an increase in serum levels of IL-6 and TGF-beta1 (P<0.01 and P<0.05, respectively). Progesterone 86-98 interleukin 1 beta Homo sapiens 46-54 26446923-9 2015 In comparison to the explants treated only with LPS, pre-treatment with 0.01-1.0 muM progesterone significantly blunted (73, 56, 56, 75, 25, 48 %) the secretion of TNF-alpha, IL-1beta, IL-6, IL-8, MIP-1alpha, IL-10, respectively. Progesterone 85-97 interleukin 1 beta Homo sapiens 175-183 23030238-8 2013 LPS-induced IL-6, IL-1beta, and BLC expression was attenuated in human monocytes treated with estrogen and progesterone. Progesterone 107-119 interleukin 1 beta Homo sapiens 18-26 24161591-2 2014 In this study, we have used human myometrial cells to investigate whether cAMP potentiates the ability of progesterone to repress IL-1beta-driven COX-2 expression. Progesterone 106-118 interleukin 1 beta Homo sapiens 130-138 12788874-0 2003 Interleukin-1 beta stimulates progesterone production by in vitro human luteal cells: evidence of a mediatory role of prostaglandins. Progesterone 30-42 interleukin 1 beta Homo sapiens 0-18 22294087-5 2012 Cell death of JEG-3 cells in response to IL-1beta was significantly decreased by co-treatment with 100 nM and 1000 nM progesterone and completely abolished at a progesterone concentration of 1000 nM. Progesterone 118-130 interleukin 1 beta Homo sapiens 41-49 22294087-5 2012 Cell death of JEG-3 cells in response to IL-1beta was significantly decreased by co-treatment with 100 nM and 1000 nM progesterone and completely abolished at a progesterone concentration of 1000 nM. Progesterone 161-173 interleukin 1 beta Homo sapiens 41-49 16772530-7 2006 Using chromatin immunoprecipitation, we observed that IL-1beta stimulated recruitment of NF-kappaB p65 to both proximal and distal NF-kappaB elements of the COX-2 promoter; these effects were diminished by coincubation with progesterone. Progesterone 224-236 interleukin 1 beta Homo sapiens 54-62 22064385-0 2012 Interleukin 1beta regulates progesterone metabolism in human cervical fibroblasts. Progesterone 28-40 interleukin 1 beta Homo sapiens 0-17 22064385-9 2012 Interleukin 1beta treatment significantly increased progesterone metabolism by these cells. Progesterone 52-64 interleukin 1 beta Homo sapiens 0-17 22064385-11 2012 Our results indicate that a major proinflammatory cytokine, IL-1beta, can facilitate local progesterone metabolism in a cell type critical for maintaining cervical structure via regulating expression of AKR1C1 and 2. Progesterone 91-103 interleukin 1 beta Homo sapiens 60-68 23209664-3 2012 We used reporter constructs to demonstrate that interleukin 1beta (IL-1beta) inhibits progesterone driven PRE activation via p65 activation and that IL-1beta reduced progesterone driven gene expression (FKBP5). Progesterone 86-98 interleukin 1 beta Homo sapiens 48-65 23209664-3 2012 We used reporter constructs to demonstrate that interleukin 1beta (IL-1beta) inhibits progesterone driven PRE activation via p65 activation and that IL-1beta reduced progesterone driven gene expression (FKBP5). Progesterone 86-98 interleukin 1 beta Homo sapiens 67-75 20843944-9 2010 We confirmed significant down-regulation of a number of genes that have been well characterized as progesterone sensitive (IL-1B, IL-6, PTGS2, and GJA1). Progesterone 99-111 interleukin 1 beta Homo sapiens 123-128 16272305-3 2005 Estradiol inhibited the IL-1beta-mediated mRNA expression and secretion of human beta-defensin-2 and CXCL8 by uterine epithelial cells while progesterone had no effect. Progesterone 141-153 interleukin 1 beta Homo sapiens 24-32 12788874-1 2003 We have investigated whether IL-1 beta, a cytokine with an important role in ovarian physiology, is also involved in progesterone (P) synthesis in human luteal cells, and whether this effect is mediated via the cyclooxygenase (COX) pathway. Progesterone 117-129 interleukin 1 beta Homo sapiens 29-38 12377625-6 2002 A positive correlation was observed between the sera concentrations of IL-1beta and estradiol on the day when human chorionic gonadotrophin (hCG) was injected (r=0.92, P<0.001), while on the same day the concentration of IL-1beta was shown to be inversely correlated with progesterone levels (r=-0.34, P<0.05). Progesterone 275-287 interleukin 1 beta Homo sapiens 71-79 12710746-10 2003 CONCLUSIONS: Production by GF of numerous MMPs in response to IL-1beta was significantly reduced by progesterone. Progesterone 100-112 interleukin 1 beta Homo sapiens 62-70 12361727-7 2002 After 6 days of preincubation, all three stimuli increased progesterone production, and this preincubation period was used in the remainder of the study.LH and IL-1beta increased the intracellular levels of 5,6-epoxyeicosatrienoic acid (5,6-EpETrE) maximally after 10 min, whereas db. Progesterone 59-71 interleukin 1 beta Homo sapiens 160-168 12515149-0 2000 [The change in placental estradiol-progesterone ratio and its relationship with the fetal membrane"s response to IL-1 beta in labor]. Progesterone 35-47 interleukin 1 beta Homo sapiens 113-122 10871649-4 2000 The IL-1beta-induced MCP-1 expression was even higher following pretreatment of cells with both oestradiol (10(-9) mol/l) and progesterone (5x10(-8) mol/l). Progesterone 126-138 interleukin 1 beta Homo sapiens 4-12 10735588-8 2000 IL-1 beta (5-50 ng/mL) increased the basal, but not LH-dependent, progesterone production from these cells in a dose-dependent manner after 96 and 144 hr of culture (P<0.05). Progesterone 66-78 interleukin 1 beta Homo sapiens 0-9 10690908-4 2000 In the present study we report that estradiol (E2) enhances endometriotic cell responsiveness to the proinflammatory cytokine interleukin-1beta by up-regulating interleukin-1-induced monocyte chemotactic protein-1 (MCP-1) expression at the level of both protein secretion and messenger ribonucleic acid (mRNA) synthesis, whereas progesterone had no significant effects. Progesterone 329-341 interleukin 1 beta Homo sapiens 126-143 9168406-4 1997 Isolated peripheral blood mononuclear cells from healthy women, but not CFS patients, exhibited significant menstrual cycle-related differences in IL-1 beta secretion that were related to estradiol and progesterone levels (R2 = 0.65, P < 0.01). Progesterone 202-214 interleukin 1 beta Homo sapiens 147-156 10566679-1 1999 The present investigation examined the effect of interleukin-1beta (IL-1beta) on progesterone production by human luteal cells and the expression and localization of the IL-1 system in the human corpus luteum (CL). Progesterone 81-93 interleukin 1 beta Homo sapiens 68-76 10566679-6 1999 The treatment of mixed luteal cells (total luteal cells) with IL-1beta inhibited by 60% hCG-stimulated progesterone production. Progesterone 103-115 interleukin 1 beta Homo sapiens 62-70 9811536-3 1998 Interleukin (IL)-1 and tumour necrosis factor (TNF)-alpha suppress 17beta-estradiol (E2) and progesterone release from granulosa and luteal cells in vitro. Progesterone 93-105 interleukin 1 beta Homo sapiens 0-18 9305807-1 1997 We have investigated the roles of interleukin-1beta as a regulator of progesterone and chorionic gonadotrophin production from human placental cells. Progesterone 70-82 interleukin 1 beta Homo sapiens 34-51 9305807-4 1997 Immortalised trophoblast cells responded to IL-1beta by increasing progesterone production through a cyclic AMP-dependent mechanism, but hCG production by these cells was unaffected by IL-1beta or dibutyryl cyclic AMP. Progesterone 67-79 interleukin 1 beta Homo sapiens 44-52 9305807-5 1997 Further studies are needed to identify the role of IL-1beta as a possible regulator of progesterone production in primary placental cells. Progesterone 87-99 interleukin 1 beta Homo sapiens 51-59 9168406-8 1997 These results suggest that an abnormality exists in IL-1 beta secretion in CFS patients that may be related to altered sensitivity to estradiol and progesterone. Progesterone 148-160 interleukin 1 beta Homo sapiens 52-61 9047011-10 1997 Interestingly, IL-1 beta inhibited this hCG stimulation of progesterone production. Progesterone 59-71 interleukin 1 beta Homo sapiens 15-24 9239666-14 1996 Treatment with IFN/TNF, TNF, and IL-1 also decreased progesterone secretion, although statistical significance was not achieved. Progesterone 53-65 interleukin 1 beta Homo sapiens 33-37 9047011-0 1997 Interleukin-1 beta modulates prostaglandin and progesterone production by primate luteal cells in vitro. Progesterone 47-59 interleukin 1 beta Homo sapiens 0-18 9047011-3 1997 In the present study we examined the effects of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha), and interferon-gamma (IFN-gamma) on progesterone and prostaglandin (PGE2, PGF2 alpha) production by primate luteal cells in vitro. Progesterone 157-169 interleukin 1 beta Homo sapiens 48-66 7792388-0 1995 Interleukin-1 beta-stimulated PGE2 production from early first trimester human decidual cells is inhibited by dexamethasone and progesterone. Progesterone 128-140 interleukin 1 beta Homo sapiens 0-18 8641202-2 1996 In FSH-treated cells, IL1 beta (0.3-30 ng/ml) inhibited progesterone biosynthesis in a dose-dependent manner, an effect that was also observed in cells exposed to increasing concentrations of bacterial SMase (0.003-0.3 U/ml) or the membrane-permeable ceramide analogue N-hexanoylsphingosine (C6-cer:0.1-10 microM). Progesterone 56-68 interleukin 1 beta Homo sapiens 22-30 7546248-0 1995 Prevention of human recombinant interleukin-1 beta (rhIL-1 beta) embryolethality with progesterone or indomethacin. Progesterone 86-98 interleukin 1 beta Homo sapiens 32-50 7623327-2 1995 Gonadotrophin-stimulated progesterone production is inhibited by interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), or gamma-interferon (IFN-gamma), the last two cytokine being more effective than IL-1. Progesterone 25-37 interleukin 1 beta Homo sapiens 65-83 7623327-2 1995 Gonadotrophin-stimulated progesterone production is inhibited by interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), or gamma-interferon (IFN-gamma), the last two cytokine being more effective than IL-1. Progesterone 25-37 interleukin 1 beta Homo sapiens 85-94 7623327-2 1995 Gonadotrophin-stimulated progesterone production is inhibited by interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), or gamma-interferon (IFN-gamma), the last two cytokine being more effective than IL-1. Progesterone 25-37 interleukin 1 beta Homo sapiens 85-89 8641202-0 1996 Interleukin-1 beta stimulates sphingomyelin hydrolysis in cultured granulosa cells: evidence for a regulatory role of ceramide on progesterone and prostaglandin biosynthesis. Progesterone 130-142 interleukin 1 beta Homo sapiens 0-18 8822445-5 1995 Our results indicate that progesterone synthesis by basal and human chorionic gonadotrophin (HCG)-stimulated granulosa cells co-cultured with white blood cells was inhibited by 5.0 ng/ml of IL-1 alpha and IL-1 beta at 48 h of culture. Progesterone 26-38 interleukin 1 beta Homo sapiens 205-214 7792388-5 1995 Progesterone (10(-7)-10(-6) M) and dexamethasone (10(-7)-10(-6) M) inhibited basal and interleukin-1 beta-stimulated prostaglandin production, and decreased the numbers of COX-2 positive cells. Progesterone 0-12 interleukin 1 beta Homo sapiens 87-105 2584355-0 1989 Progesterone and estradiol modulate interleukin-1 beta messenger ribonucleic acid levels in cultured human peripheral monocytes. Progesterone 0-12 interleukin 1 beta Homo sapiens 36-54 2584355-8 1989 In both cases, IL-1 beta mRNA levels decreased by 80-90% as the progesterone concentration increased to 10(-5) M and by 70-90% as the estradiol concentration increased similarly. Progesterone 64-76 interleukin 1 beta Homo sapiens 15-24 2584355-9 1989 A similar 80% decrease in IL-1 beta mRNA was observed with peritoneal macrophages incubated with increasing amounts of progesterone. Progesterone 119-131 interleukin 1 beta Homo sapiens 26-35 8126130-9 1994 The monocyte cytokines [IL-1 alpha (5 U/mL), IL-1 beta (5 U/mL), and TNF alpha (1000 U/mL) significantly stimulated trophoblast progesterone production (nanograms per mL): JEG-3 control, 4.1 +/- 0.5; IL-1 alpha, 7.8 +/- 0.9; IL-1 beta, 8.8 +/- 0.5; and TNF alpha 7.2 +/- 0.8 (P < 0.05). Progesterone 128-140 interleukin 1 beta Homo sapiens 45-54 8126130-15 1994 We conclude that monocyte IL-1 alpha, IL-1 beta, and TNF alpha may regulate trophoblast progesterone production through paracrine effects. Progesterone 88-100 interleukin 1 beta Homo sapiens 38-47 8437102-7 1993 Progesterone 6 beta-hydroxylation and P-450 IIIA protein increased by 2-fold in both untreated arthritic rat liver microsomes and those treated by the lowest dose of IL-1. Progesterone 0-12 interleukin 1 beta Homo sapiens 166-170 2541588-9 1989 Moreover, the conversion of exogenously added androgen precursors (progesterone and 17 alpha-hydroxyprogesterone) to testosterone by human chorionic gonadotropin-stimulated cells was suppressed by interleukin-1 beta suggesting that the activity of the 17 alpha-hydroxylase enzyme may be decreased. Progesterone 67-79 interleukin 1 beta Homo sapiens 197-215