PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11259876-8 2001 EGF in combination with FSH (100ng/ml culture medium) significantly (P<0.05) stimulated progesterone secretion by cultured granulosa cells from all three categories of follicles even at the lowest dose (0.1ng/ml culture medium) tested. Progesterone 91-103 epidermal growth factor Homo sapiens 0-3 19138738-8 2009 The results showed that genes presenting the epidermal growth factor (EGF)/MAP-kinase pathway were significantly over-represented by progesterone treatment, whereas, by Mifepristone treatment genes involved in the p53 pathway were also up-regulated (data not shown). Progesterone 133-145 epidermal growth factor Homo sapiens 45-68 19138738-8 2009 The results showed that genes presenting the epidermal growth factor (EGF)/MAP-kinase pathway were significantly over-represented by progesterone treatment, whereas, by Mifepristone treatment genes involved in the p53 pathway were also up-regulated (data not shown). Progesterone 133-145 epidermal growth factor Homo sapiens 70-73 15140868-6 2004 Since it is now evident that EGF and IGF-I act as local factors which stimulate leiomyoma growth, these findings suggest that progesterone may have dual actions, stimulatory and inhibitory, on leiomyoma cell growth and survival, depending on the local growth factor conditions around each leiomyoma. Progesterone 126-138 epidermal growth factor Homo sapiens 29-32 14532844-13 2003 In addition, progesterone stimulated urothelial cell proliferation was inhibited by neutralizing EGF antibody but not by NGF antiserum or K252a. Progesterone 13-25 epidermal growth factor Homo sapiens 97-100 14532844-14 2003 We also found that EGF synthesis and release by urothelial cells was increased by exogenous progesterone. Progesterone 92-104 epidermal growth factor Homo sapiens 19-22 15084247-4 2004 In the present study we identify an effect of EGF on a progesterone target, namely desmoplakin. Progesterone 55-67 epidermal growth factor Homo sapiens 46-49 15084247-8 2004 RESULTS: We found the cell adhesion protein desmoplakin to be upregulated by progesterone - a process that was suppressed by EGF. Progesterone 77-89 epidermal growth factor Homo sapiens 125-128 11773440-9 2002 Moreover, GPR30-dependent, cAMP-mediated attenuation of EGF-induced Erk-1/-2 activity was achieved by ER antagonists such as tamoxifen or ICI 182, 780; yet not by 17alpha-E2 or progesterone. Progesterone 177-189 epidermal growth factor Homo sapiens 56-59 8020171-3 1994 At 1 ng, 2 ng, and 3 ng per ml medium EGF significantly enhanced basal progesterone and estradiol secretion and significantly decreased hCG stimulated estradiol production of preovulatory granulosa cells. Progesterone 71-83 epidermal growth factor Homo sapiens 38-41 11182513-9 2001 EGF (10ng/ml) failed to affect the progesterone synthesis during 72h culture of SGC but significantly enhanced the LGC progesterone production. Progesterone 119-131 epidermal growth factor Homo sapiens 0-3 11035985-13 2000 In addition, decreased EGF may be secondary to the predominant estrogenic milieu present at time of sampling, as it has been proposed that progesterone, and not estrogen, may regulate EGF. Progesterone 139-151 epidermal growth factor Homo sapiens 23-26 11035985-13 2000 In addition, decreased EGF may be secondary to the predominant estrogenic milieu present at time of sampling, as it has been proposed that progesterone, and not estrogen, may regulate EGF. Progesterone 139-151 epidermal growth factor Homo sapiens 184-187 10682457-8 1998 CONCLUSION: These findings suggested that: (1) EGF mRNA levels in leiomyoma were increased only in the luteal phase, therefore, maybe mainly controlled by progesterone; (2) mifepristone inhibited EGF gene expression in leiomyoma. Progesterone 155-167 epidermal growth factor Homo sapiens 47-50 8882285-1 1996 The aim of this study was to investigate the effect of oestradiol and progesterone on epidermal growth factor (EGF) binding in human endometrial glands and stromal cells in culture. Progesterone 70-82 epidermal growth factor Homo sapiens 86-109 8882285-1 1996 The aim of this study was to investigate the effect of oestradiol and progesterone on epidermal growth factor (EGF) binding in human endometrial glands and stromal cells in culture. Progesterone 70-82 epidermal growth factor Homo sapiens 111-114 8882285-6 1996 Oestradiol and progesterone in combination caused a greater increase in EGF receptor concentration than did either steroid alone (control, 100 +/- 11%; oestradiol, 144 +/- 11% control; progesterone, 200 +/- 20% control; oestradiol and progesterone, 288 +/- 6% control). Progesterone 15-27 epidermal growth factor Homo sapiens 72-75 8882285-11 1996 These data demonstrate that oestradiol and progesterone increase the number of EGF receptors in vitro, and suggest that EGF is involved in mediating the actions of these steroids on the processes of proliferation and differentiation in the human endometrium. Progesterone 43-55 epidermal growth factor Homo sapiens 79-82 7872715-5 1994 Addition of progesterone and estradiol significantly increased the release of EGF/TGF-a from benign tumour tissue but did not stimulate release from control ovaries. Progesterone 12-24 epidermal growth factor Homo sapiens 78-81 11182513-6 2001 Stimulatory effect of EGF on the cumulus expansion of OCC isolated from large follicles was accompanied by the increased cumulus cell progesterone production. Progesterone 134-146 epidermal growth factor Homo sapiens 22-25 9281894-6 1997 EGF has also got a suppressive effect on 17 a-hydroxylase enzyme; a key enzyme which is necessary for the hydroxylation of pregnenolone and progesterone in the ovary Hydroxy pregnenolone is a precursor of androstendione, while 17 a-hydroxyprogesterone is a precursor of testosterone. Progesterone 140-152 epidermal growth factor Homo sapiens 0-3 8543926-10 1995 Increase in the amounts of EGF receptor protein and mRNA occurred in association with an increase in serum oestradiol but not progesterone levels. Progesterone 126-138 epidermal growth factor Homo sapiens 27-30 8624430-9 1995 Furthermore, tyrphostin, an EGF-R-specific tyrosine kinase inhibitor, inhibited both basal and growth factor-stimulated progesterone production. Progesterone 120-132 epidermal growth factor Homo sapiens 28-31 8624430-10 1995 CONCLUSION: These data suggest an EGF receptor-mediated physiological role for EGF and TGF-alpha in human luteal function involving an autocrine and/or a paracrine stimulation of progesterone production. Progesterone 179-191 epidermal growth factor Homo sapiens 34-37 1770127-7 1991 However, oestradiol in combination with progesterone and cortisol further increased EGF binding. Progesterone 40-52 epidermal growth factor Homo sapiens 84-87 8364119-0 1993 [The effect of progesterone and tamoxifen on EGF-dependent activation of phospholipid turnover in uterine and breast tumor cells]. Progesterone 15-27 epidermal growth factor Homo sapiens 45-48 8364119-4 1993 However, in 10 out of 11 positively responding to EGF adenocarcinomas progesterone inhibited the EGF-dependent activation of 32P incorporation into the phospholipids already on the 15th min after its addition to the cells. Progesterone 70-82 epidermal growth factor Homo sapiens 50-53 8364119-4 1993 However, in 10 out of 11 positively responding to EGF adenocarcinomas progesterone inhibited the EGF-dependent activation of 32P incorporation into the phospholipids already on the 15th min after its addition to the cells. Progesterone 70-82 epidermal growth factor Homo sapiens 97-100 8364119-9 1993 The results obtained suggest that the EGF-dependent activation of intracellular phospholipid turnover is under the negative control of progesterone. Progesterone 135-147 epidermal growth factor Homo sapiens 38-41 1517385-0 1992 The inhibitory effects of mullerian-inhibiting substance on epidermal growth factor induced proliferation and progesterone production of human granulosa-luteal cells. Progesterone 110-122 epidermal growth factor Homo sapiens 60-83 1517385-6 1992 EGF increased progesterone production per cell after 4 days exposure, but this effect was lost after 8 days. Progesterone 14-26 epidermal growth factor Homo sapiens 0-3 1517385-9 1992 Maintaining EGF at 20 ng/mL and varying rhMIS yielded significant reduction in EGF-mediated proliferation and progesterone production per cell at 2 and 20 ng/mL rhMIS. Progesterone 110-122 epidermal growth factor Homo sapiens 12-15 1517385-10 1992 These experiments demonstrate rhMIS inhibits basal and EGF-stimulated human granulosa-luteal cell proliferation and progesterone production. Progesterone 116-128 epidermal growth factor Homo sapiens 55-58 1531626-9 1992 Second, EGF, TGF beta 1, and EGF plus TGF beta 1 significantly (P less than 0.001) increased delta 5-steroid intermediate (i.e. pregnenolone and DHEA), but not delta 4-steroid intermediate (i.e. progesterone and androstenedione), conversion into testosterone, indicating that the growth factors increased, individually or in combination in an additive manner, 3 beta HSDI activity (respectively, 90.7 +/- 0.6%, 80.6 +/- 2.6%, and 164 +/- 4.5% increase in the presence of EGF, TGF beta 1, and EGF plus TGF beta 1). Progesterone 195-207 epidermal growth factor Homo sapiens 8-11 1531626-9 1992 Second, EGF, TGF beta 1, and EGF plus TGF beta 1 significantly (P less than 0.001) increased delta 5-steroid intermediate (i.e. pregnenolone and DHEA), but not delta 4-steroid intermediate (i.e. progesterone and androstenedione), conversion into testosterone, indicating that the growth factors increased, individually or in combination in an additive manner, 3 beta HSDI activity (respectively, 90.7 +/- 0.6%, 80.6 +/- 2.6%, and 164 +/- 4.5% increase in the presence of EGF, TGF beta 1, and EGF plus TGF beta 1). Progesterone 195-207 epidermal growth factor Homo sapiens 29-32 1531626-9 1992 Second, EGF, TGF beta 1, and EGF plus TGF beta 1 significantly (P less than 0.001) increased delta 5-steroid intermediate (i.e. pregnenolone and DHEA), but not delta 4-steroid intermediate (i.e. progesterone and androstenedione), conversion into testosterone, indicating that the growth factors increased, individually or in combination in an additive manner, 3 beta HSDI activity (respectively, 90.7 +/- 0.6%, 80.6 +/- 2.6%, and 164 +/- 4.5% increase in the presence of EGF, TGF beta 1, and EGF plus TGF beta 1). Progesterone 195-207 epidermal growth factor Homo sapiens 29-32 1531626-9 1992 Second, EGF, TGF beta 1, and EGF plus TGF beta 1 significantly (P less than 0.001) increased delta 5-steroid intermediate (i.e. pregnenolone and DHEA), but not delta 4-steroid intermediate (i.e. progesterone and androstenedione), conversion into testosterone, indicating that the growth factors increased, individually or in combination in an additive manner, 3 beta HSDI activity (respectively, 90.7 +/- 0.6%, 80.6 +/- 2.6%, and 164 +/- 4.5% increase in the presence of EGF, TGF beta 1, and EGF plus TGF beta 1). Progesterone 195-207 epidermal growth factor Homo sapiens 29-32 1309328-5 1992 EGF significantly (P less than 0.05) reduced hCG-induced secretion of estradiol (control, 117 +/- 12 pg/min.follicle; 10 ng/ml EGF, 55 +/- 10) and progesterone (control, 18.2 +/- 1.2 ng/min.follicle; 10 ng/ml EGF, 11.9 +/- 0.8) by the perfused ovary. Progesterone 147-159 epidermal growth factor Homo sapiens 0-3 8408478-1 1993 Epidermal growth factor (EGF) stimulates progesterone production by human granulosa--luteal cells in culture. Progesterone 41-53 epidermal growth factor Homo sapiens 0-23 8408478-1 1993 Epidermal growth factor (EGF) stimulates progesterone production by human granulosa--luteal cells in culture. Progesterone 41-53 epidermal growth factor Homo sapiens 25-28 8408478-7 1993 When EGF was initiated on day 4, the medium had significantly higher progesterone concentration than control samples on days 6, 8, 10 and 12 of culture (P < 0.01). Progesterone 69-81 epidermal growth factor Homo sapiens 5-8 8408478-8 1993 When EGF was withheld until day 6 or 8, progesterone concentrations were not significantly higher than control values. Progesterone 40-52 epidermal growth factor Homo sapiens 5-8 8408478-9 1993 When EGF was added on day 4 and discontinued on day 8 or 10, progesterone concentrations were reduced significantly (P < 0.001) compared with the group where EGF was added continuously from day 4 to 10. Progesterone 61-73 epidermal growth factor Homo sapiens 5-8 8408478-10 1993 These data suggest that: (i) human granulosa--luteal cells require the early exposure and continuous presence of EGF for the stimulatory effect on progesterone secretion, (ii) cells not exposed initially to EGF do not respond in a similar way, (iii) EGF is capable of maintaining progesterone production for a period > 12 days. Progesterone 147-159 epidermal growth factor Homo sapiens 113-116 8445028-8 1993 Further, epidermal growth factor (EGF) stimulated cell proliferation, and continuous exposure to progesterone blocked EGF-induced mitosis. Progesterone 97-109 epidermal growth factor Homo sapiens 118-121 1541863-7 1992 EGF inhibited the secretion of estradiol, and increased the secretion of progesterone by cultured cells. Progesterone 73-85 epidermal growth factor Homo sapiens 0-3 1541863-11 1992 Thus, EGF is likely to act in an autocrine manner to stimulate the proliferation of less mature granulosa cells and to increase progesterone production by mature granulosa cells in association with an inhibitory action on estradiol production. Progesterone 128-140 epidermal growth factor Homo sapiens 6-9 1801845-8 1991 It is therefore suggested that EGF, insulin and selenium may possibly be involved in the regulation of hCG and progesterone secretion in the human placenta. Progesterone 111-123 epidermal growth factor Homo sapiens 31-34 2055947-0 1991 Progesterone augments proliferation induced by epidermal growth factor in a feline mammary adenocarcinoma cell line. Progesterone 0-12 epidermal growth factor Homo sapiens 47-70 1905128-4 1991 The ratios progesterone/estradiol and testosterone/estradiol increase, when EGF is added to the culture medium. Progesterone 11-23 epidermal growth factor Homo sapiens 76-79 2055947-11 1991 Stimulation of K12 cells by PGN or by R5020 induced a two- to threefold increase in the number of high-affinity surface EGF receptors after 24 h. Stimulation of these cells by PGN also affected the relative levels of phosphorylation of the EGF receptor and p185 within minutes, but not of other cellular phosphoproteins. Progesterone 28-31 epidermal growth factor Homo sapiens 120-123 2055947-11 1991 Stimulation of K12 cells by PGN or by R5020 induced a two- to threefold increase in the number of high-affinity surface EGF receptors after 24 h. Stimulation of these cells by PGN also affected the relative levels of phosphorylation of the EGF receptor and p185 within minutes, but not of other cellular phosphoproteins. Progesterone 28-31 epidermal growth factor Homo sapiens 240-243 2055947-11 1991 Stimulation of K12 cells by PGN or by R5020 induced a two- to threefold increase in the number of high-affinity surface EGF receptors after 24 h. Stimulation of these cells by PGN also affected the relative levels of phosphorylation of the EGF receptor and p185 within minutes, but not of other cellular phosphoproteins. Progesterone 176-179 epidermal growth factor Homo sapiens 120-123 2055947-11 1991 Stimulation of K12 cells by PGN or by R5020 induced a two- to threefold increase in the number of high-affinity surface EGF receptors after 24 h. Stimulation of these cells by PGN also affected the relative levels of phosphorylation of the EGF receptor and p185 within minutes, but not of other cellular phosphoproteins. Progesterone 176-179 epidermal growth factor Homo sapiens 240-243 2055947-12 1991 Our results show that PGN enhances the EGF-induced growth of K12 cells and suggest that this effect may be mediated at least partly via an increase in the number or function of high-affinity EGF receptors. Progesterone 22-25 epidermal growth factor Homo sapiens 39-42 2055947-12 1991 Our results show that PGN enhances the EGF-induced growth of K12 cells and suggest that this effect may be mediated at least partly via an increase in the number or function of high-affinity EGF receptors. Progesterone 22-25 epidermal growth factor Homo sapiens 191-194 1947220-3 1991 Epidermal growth factor (EGF) and human transforming growth factor type beta (TGF-beta) decreased basal and gonadotrophin-stimulated inhibin and progesterone in a dose-dependent manner. Progesterone 145-157 epidermal growth factor Homo sapiens 0-23 1947220-3 1991 Epidermal growth factor (EGF) and human transforming growth factor type beta (TGF-beta) decreased basal and gonadotrophin-stimulated inhibin and progesterone in a dose-dependent manner. Progesterone 145-157 epidermal growth factor Homo sapiens 25-28 2209924-15 1990 The secretion of prolactin in the group treated with progesterone alone decreased dose-dependently responding to added EGF on the 8th day of culture. Progesterone 53-65 epidermal growth factor Homo sapiens 119-122 2172119-7 1990 Progesterone treatment stimulated a significant increase in EGF and IGF-1 receptors in gland cultures. Progesterone 0-12 epidermal growth factor Homo sapiens 60-63 2209924-16 1990 In the presence of estradiol and progesterone, the secretion rate decreased to the values similar to the progesterone alone group with the addition of 0.1, 1 ng/ml EGF, and the decrease in prolactin secretion was less with the addition of 10 ng/ml EGF. Progesterone 33-45 epidermal growth factor Homo sapiens 164-167 2209924-16 1990 In the presence of estradiol and progesterone, the secretion rate decreased to the values similar to the progesterone alone group with the addition of 0.1, 1 ng/ml EGF, and the decrease in prolactin secretion was less with the addition of 10 ng/ml EGF. Progesterone 33-45 epidermal growth factor Homo sapiens 248-251 34817509-4 2021 Progesterone functions mainly by interacting with intracellular progesterone receptors to modify the expression of the genes involved in cell proliferation, angiogenesis, and epidermal growth factor production. Progesterone 0-12 epidermal growth factor Homo sapiens 175-198 2173938-3 1990 Similarly, a 470-fold difference in the ability of TGF alpha (ID50 = 0.13 nM) versus EGF (ID50 = 61.3 nM) to half-maximally suppress LH-induced progesterone production was observed in the same cells. Progesterone 144-156 epidermal growth factor Homo sapiens 85-88 2173938-4 1990 Progesterone production stimulated by a cAMP analogue (8-bromo-cAMP, 1 mM) was also attenuated by EGF (ID50 = 75.9 nM) and TGF alpha (ID50 = 0.08 nM), suggesting a post-cAMP site of inhibition by these growth factors on steroidogenesis. Progesterone 0-12 epidermal growth factor Homo sapiens 98-101 3044580-2 1988 Studies with the soluble and particulate fractions prepared after homogenization of T47D cells grown in glass roller bottles revealed equivalent EGF-induced decreases in progesterone binding to receptors in both fractions. Progesterone 170-182 epidermal growth factor Homo sapiens 145-148 2558432-3 1989 None significantly affected intracellular levels of cAMP, and only epidermal growth factor (EGF) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulated progesterone production. Progesterone 156-168 epidermal growth factor Homo sapiens 67-90 2558432-3 1989 None significantly affected intracellular levels of cAMP, and only epidermal growth factor (EGF) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulated progesterone production. Progesterone 156-168 epidermal growth factor Homo sapiens 92-95 2569034-5 1989 Statistically significant inverse correlations were found between the binding capacities of estrogen and EGF receptors as well as between Bmax of progesterone and EGF receptors. Progesterone 146-158 epidermal growth factor Homo sapiens 163-166 3044580-5 1988 The decrease in progesterone binding induced by 20 nM EGF was maximal after 2 min of cellular EGF treatment for receptors recovered in the soluble fraction, but was only half-maximal after 15 min for receptors recovered in the particulate fraction. Progesterone 16-28 epidermal growth factor Homo sapiens 54-57 3044580-5 1988 The decrease in progesterone binding induced by 20 nM EGF was maximal after 2 min of cellular EGF treatment for receptors recovered in the soluble fraction, but was only half-maximal after 15 min for receptors recovered in the particulate fraction. Progesterone 16-28 epidermal growth factor Homo sapiens 94-97 6093706-6 1984 The increase in EGF binding is specific for glucocorticoids, occurring when the HeLa S3 cells are exposed to 10(-7) M cortisol or dexamethasone for 24 h, but not when the cells are similarly treated with testosterone, 5 alpha-dihydroxytestosterone, 17 beta-estradiol, or progesterone. Progesterone 271-283 epidermal growth factor Homo sapiens 16-19 3009155-0 1986 Inhibitory action of epidermal growth factor on progesterone biosynthesis in hen granulosa cells during short term culture: two sites of action. Progesterone 48-60 epidermal growth factor Homo sapiens 21-44 3009155-1 1986 The acute effect of epidermal growth factor (EGF) on progesterone biosynthesis by hen granulosa cells in short term culture was investigated. Progesterone 53-65 epidermal growth factor Homo sapiens 20-43 3009155-1 1986 The acute effect of epidermal growth factor (EGF) on progesterone biosynthesis by hen granulosa cells in short term culture was investigated. Progesterone 53-65 epidermal growth factor Homo sapiens 45-48 3009155-2 1986 Pretreatment of cells for 5 h with EGF at concentrations of 1000-4000 ng/ml inhibited LH-stimulated progesterone production by 54%. Progesterone 100-112 epidermal growth factor Homo sapiens 35-38 3009155-3 1986 Shorter EGF pretreatment times of 1 and 3 h caused 25% and 35% inhibition of LH-stimulated progesterone production, respectively. Progesterone 91-103 epidermal growth factor Homo sapiens 8-11 3009155-4 1986 In additional experiments, EGF was found to inhibit progesterone production in response to 8-bromo-cAMP (1 mM) and forskolin (100 microM) by 34% and 35%, respectively. Progesterone 52-64 epidermal growth factor Homo sapiens 27-30 3009155-5 1986 EGF had no effect on the conversion of 25-hydroxy-cholesterol or pregnenolone to progesterone, indicating that one site at which EGF inhibits progesterone biosynthesis is distal to cAMP generation, but before the side-chain cleavage step. Progesterone 142-154 epidermal growth factor Homo sapiens 129-132 3009155-9 1986 The results demonstrate that the acute inhibitory effect of EGF on LH-stimulated progesterone biosynthesis in hen granulosa cells is due to its action at two sites: one at a site before the production of cAMP and the other at a step beyond cAMP generation. Progesterone 81-93 epidermal growth factor Homo sapiens 60-63 6968677-1 1980 Epidermal growth factor (EGF) stimulates the production of progesterone by JEG-3, a clonal strain of human choriocarcinoma cells. Progesterone 59-71 epidermal growth factor Homo sapiens 0-23 6968677-1 1980 Epidermal growth factor (EGF) stimulates the production of progesterone by JEG-3, a clonal strain of human choriocarcinoma cells. Progesterone 59-71 epidermal growth factor Homo sapiens 25-28 6968677-3 1980 In addition, EGF increases [14C]-acetate incorporation into [14C]-cholesterol in JEG-3 cells, and this may constitute its mechanism of action in enhancing progesterone synthesis. Progesterone 155-167 epidermal growth factor Homo sapiens 13-16