PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10505058-13	1999	The greater proliferation rate of granulosa cells of chickens fed ad libitum, in response to insulin-like growth factor I alone or in combination with gonadotrophins, leading to the simultaneous differentiation of two or three large follicles with high progesterone production in response to LH or insulin-like growth factor I, accelerates the rate of maturation of follicles.	Progesterone	253-265	insulin like growth factor 1	Gallus gallus	93-121	
10505058-0	1999	Differential effects of amount of feeding on cell proliferation and progesterone production in response to gonadotrophins and insulin-like growth factor I by ovarian granulosa cells of broiler breeder chickens selected for fatness or leanness.	Progesterone	68-80	insulin like growth factor 1	Gallus gallus	126-154	
10505058-6	1999	In culture, granulosa cells from the three largest follicles (F1, F2 and F3) increased progesterone production in response to LH, FSH and insulin-like growth factor I but responses were different between the GL and FC lines fed either ad libitum or restricted diets.	Progesterone	87-99	insulin like growth factor 1	Gallus gallus	138-166	
10505058-7	1999	Granulosa cells from the two or three largest follicles in GL and FC (ad libitum) lines produced similar amounts of progesterone in response to LH, FSH and insulin-like growth factor I whereas, in restricted birds, the progesterone production was of the rank order F1 > F2 > F3 in both lines.	Progesterone	116-128	insulin like growth factor 1	Gallus gallus	156-184	
10505058-10	1999	Insulin-like growth factor I combined with LH or FSH significantly increased the progesterone production of granulosa cells from birds fed restricted diets of both lines and this effect increased with increasing follicular size.	Progesterone	81-93	insulin like growth factor 1	Gallus gallus	0-28	
17478073-13	2008	Thus, a variation of energy metabolism through AMPK activation could modulate differently IGF-1-induced progesterone production in F1 and F3/4 granulosa cells.	Progesterone	104-116	insulin like growth factor 1	Gallus gallus	90-95	
17478073-5	2008	In vitro, IGF-1 treatment (10(-8)M, 36h) increased progesterone secretion by four-fold in mixed F3 and F4 (F3/4) granulosa cells and by 1.5-fold in F1 granulosa cells.	Progesterone	51-63	insulin like growth factor 1	Gallus gallus	10-15	
17478073-9	2008	We then studied the effects of AMPK activation by AICAR (5-aminoimidazole-4-carboxamide ribonucleoside), an activator of AMPK, on IGF-1-induced progesterone secretion by F3/4 and F1 granulosa cells.	Progesterone	144-156	insulin like growth factor 1	Gallus gallus	130-135	
7473417-3	1995	IGF-I stimulated progesterone production from granulosa cells of all the follicles with no change in ED50 value during follicular maturation; however, the maximum response was from cells derived from F1 follicles.	Progesterone	17-29	insulin like growth factor 1	Gallus gallus	0-5	
7473417-4	1995	IGF-I plus LH had an additive effect on progesterone production by cells from all follicles.	Progesterone	40-52	insulin like growth factor 1	Gallus gallus	0-5	
7473417-5	1995	In contrast, TGF-alpha inhibited basal and LH- and IGF-I-stimulated progesterone production.	Progesterone	68-80	insulin like growth factor 1	Gallus gallus	51-56	
17010558-9	2007	However, it increased by about two-fold IGF-1-induced progesterone secretion in F2 and F3/4 follicles whereas it halved progesterone production in response to gonadotropins (LH and FSH) in F3/4 follicles.	Progesterone	54-66	insulin like growth factor 1	Gallus gallus	40-45