PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10888271-4	2000	We have shown that polyamines, hormones (including estrogen, testosterone and progesterone), antihormones (including tamoxifen and flutamide) and various antidepressants and antihistamines, all inhibit histamine binding to P450; we have postulated that, through binding to the heme moiety, intracellular histamine regulates cell function by modulating the catalytic activity of P450 enzymes, an action that may be perturbed by endogenous and exogenous substances.	Progesterone	78-90	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	223-227	
10403825-5	1999	This P450 exhibited 6beta-hydroxylation activity toward both testosterone and progesterone.	Progesterone	78-90	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	5-9	
8969926-6	1996	Incubation of the purified enzyme with steroid in a reaction vessel containing a platinum electrode and a Ag/AgCl electrode couple poised at -650 mV, together with the electromotively active redox mediator, cobalt sepulchrate, results in the 17 alpha-hydroxylation of progesterone at rates as high as 25 nmoles of progesterone hydroxylated/min/nmole of P450.	Progesterone	268-280	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	353-357	
9328296-1	1997	Roles of human cytochrome P450 (P450 or CYP) 2C9, 2C19, and 3A4 in the oxidation of progesterone and testosterone were studied in recombinant P450 enzymes and in human liver microsomes.	Progesterone	84-96	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	32-48	
8969926-6	1996	Incubation of the purified enzyme with steroid in a reaction vessel containing a platinum electrode and a Ag/AgCl electrode couple poised at -650 mV, together with the electromotively active redox mediator, cobalt sepulchrate, results in the 17 alpha-hydroxylation of progesterone at rates as high as 25 nmoles of progesterone hydroxylated/min/nmole of P450.	Progesterone	314-326	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	353-357	
8632407-10	1996	P450 17: K(m)progesterone = 7 microM, K(i)16 = 9 microM, K(i)20 = 80 nM).	Progesterone	13-25	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-4	
31339834-1	2019	PURPOSE: Hydroxylation activity at the 6beta-position of steroid hormones (testosterone, progesterone, and cortisol) by human cytochromes P450 (P450 or CYP) 3A4 and CYP3A5 and their molecular docking energy values were compared to understand the catalytic properties of the major forms of human CYP3A, namely, CYP3A4 and CYP3A5.	Progesterone	89-101	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	126-160	
22837389-0	2013	Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone.	Progesterone	76-88	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	43-47	
22837389-4	2013	The results showed that estradiol enhances CYP2A6, CYP2B6, and CYP3A4 expression, whereas progesterone induces CYP2A6, CYP2B6, CYP2C8, CYP3A4, and CYP3A5 expression.	Progesterone	90-102	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	119-125	
3502608-3	1987	The levels of mRNAs for the rate-limiting enzymes in the conversion of cholesterol into progesterone, namely cholesterol side-chain cleavage cytochrome P-450 and its electron donor, adrenodoxin, were higher in corpora lutea than in follicles.	Progesterone	88-100	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	152-157	
3502608-4	1987	Conversely the levels of mRNA specific for the key regulatory enzyme in the conversion of pregnenolone or progesterone to androgen, namely 17 alpha-hydroxylase cytochrome P-450, were high in all antral follicles examined but were low in young corpora lutea and undetectable in more mature corpora lutea.	Progesterone	106-118	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	171-176	
3795953-3	1986	Progesterone and 17 alpha-hydroxyprogesterone, the enzyme"s substrates, bound stoichiometrically to microsomal P-450 with unusually high affinity (Kd = 23-51 nM).	Progesterone	0-12	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	111-116