PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32792990-6 2020 In subsequent dose response studies, medroxyprogesterone acetate, but not progesterone, at doses of 10-6-10-8 M inhibited interleukin-1beta induced interleukin-8 and matrix metalloproteinase 1 mRNA expression. Progesterone 44-56 C-X-C motif chemokine ligand 8 Homo sapiens 148-161 24128422-2 2014 We investigated the effect of lipopolysacharide (LPS) and progesterone (P4) upon expression of TLR-4/MyD88, TNFalpha, IL-6, IL-8, IL-10, and HBD2 on the human amniotic epithelium. Progesterone 58-70 C-X-C motif chemokine ligand 8 Homo sapiens 124-128 29236553-5 2018 lipopolysaccharide co-treatment with progesterone significantly decreased the bacterial endotoxin-induced IL-1beta, TNF-alpha, IL-6, IL-8, and MIP-1alpha secretion. Progesterone 37-49 C-X-C motif chemokine ligand 8 Homo sapiens 133-137 27542947-19 2016 In co-culture, IL8 secretion was also suppressed on luteal phase day 15 (P = 0.013) versus follicular phase day 7, but IL8 secretion increased continuously under high E2/progesterone treatment (P = 0.003 for D13 versus D3). Progesterone 170-182 C-X-C motif chemokine ligand 8 Homo sapiens 119-122 26446923-9 2015 In comparison to the explants treated only with LPS, pre-treatment with 0.01-1.0 muM progesterone significantly blunted (73, 56, 56, 75, 25, 48 %) the secretion of TNF-alpha, IL-1beta, IL-6, IL-8, MIP-1alpha, IL-10, respectively. Progesterone 85-97 C-X-C motif chemokine ligand 8 Homo sapiens 191-195 26321412-4 2015 IL-8 also promotes trophoblast cell migration and invasion, and stimulates the secretion of progesterone. Progesterone 92-104 C-X-C motif chemokine ligand 8 Homo sapiens 0-4 24581581-10 2014 In marginal structural models, IL-1beta, IL-6, IL-8 were associated with lower estradiol and progesterone concentrations. Progesterone 93-105 C-X-C motif chemokine ligand 8 Homo sapiens 47-51 15943769-4 2005 The production of vascular endothelial growth factor (VEGF), interleukin (IL)-6 and IL-8 by HGF increased following stimulation with estradiol or progesterone, at concentrations comparable to those present in the plasma of pregnant women. Progesterone 146-158 C-X-C motif chemokine ligand 8 Homo sapiens 84-88 21356375-7 2011 IL-8 was increased by PGE(2) and hypoxia in secretory but not proliferative explants, which suggests that exposure to progesterone is essential. Progesterone 118-130 C-X-C motif chemokine ligand 8 Homo sapiens 0-4 15613411-8 2005 The effects of estradiol (5 x 10(-8) m), progesterone (10(-7) m), or both on IL-8 mRNA and protein levels were analyzed by RT-PCR and ELISA, respectively. Progesterone 41-53 C-X-C motif chemokine ligand 8 Homo sapiens 77-81 11511305-0 2001 17beta-estradiol, progesterone, and dihydrotestosterone suppress the growth of human melanoma by inhibiting interleukin-8 production. Progesterone 18-30 C-X-C motif chemokine ligand 8 Homo sapiens 108-121 11511305-11 2001 These data suggest that 17beta-estradiol, progesterone, and dihydrotestosterone suppress the growth of melanoma by inhibiting interleukin-8 production in a receptor-dependent manner. Progesterone 42-54 C-X-C motif chemokine ligand 8 Homo sapiens 126-139 12672669-0 2003 Progesterone represses interleukin-8 and cyclo-oxygenase-2 in human lower segment fibroblast cells and amnion epithelial cells. Progesterone 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 23-36 11912286-7 2002 The immunoreactive levels of endometrial IL-8 and MCP-1 were up-regulated by the administration of progesterone during the receptive phase of the cycle. Progesterone 99-111 C-X-C motif chemokine ligand 8 Homo sapiens 41-45 8027281-4 1994 In endometrium, the stage of the menstrual cycle did not affect IL-8 production but a 10(-6) M concentration of progesterone or dexamethasone significantly reduced the concentration of IL-8 in medium after 24 h. After a further 24 h with lipopolysaccharide (LPS) stimulation, only MPA and dexamethasone inhibited production significantly. Progesterone 112-124 C-X-C motif chemokine ligand 8 Homo sapiens 185-189 10404837-6 1999 Midluteal endometrium showed minimal IL-8 expression, whereas endometrium obtained from women administered progesterone for 4 days from (LH peak + 8 days), to simulate luteal regression, demonstrated significantly increased localization of IL-8 mRNA, 48 h after withdrawal of progesterone. Progesterone 107-119 C-X-C motif chemokine ligand 8 Homo sapiens 240-244 10076137-5 1999 RESULTS: Interleukin 8 release from cervical explants was stimulated by prostaglandin E2 and nitric oxide and inhibited by progesterone and dexamethasone. Progesterone 123-135 C-X-C motif chemokine ligand 8 Homo sapiens 9-22 9920091-1 1999 The role of progesterone (P4) in the regulation of inflammatory mediators interleukin-8 (IL-8), monocyte chemoattractant protein-1, and cyclooxygenase-2 (COX-2) and in the recruitment of leukocyte subpopulations in the endometrium has been examined, by employing a model of P4 withdrawal and maintenance in vivo. Progesterone 12-24 C-X-C motif chemokine ligand 8 Homo sapiens 74-87 9920091-1 1999 The role of progesterone (P4) in the regulation of inflammatory mediators interleukin-8 (IL-8), monocyte chemoattractant protein-1, and cyclooxygenase-2 (COX-2) and in the recruitment of leukocyte subpopulations in the endometrium has been examined, by employing a model of P4 withdrawal and maintenance in vivo. Progesterone 12-24 C-X-C motif chemokine ligand 8 Homo sapiens 89-93 8756544-11 1996 Importantly, progesterone suppressed both basal and IL-1 alpha-stimulated IL-8 expression in stromal and granulosa-lutein cell types. Progesterone 13-25 C-X-C motif chemokine ligand 8 Homo sapiens 74-78 8027281-6 1994 The IL-8 produced in uterine tissues might act synergistically with prostaglandin E (PGE), a likely site for this interaction being blood vessels where PGE production is also repressed by progesterone. Progesterone 188-200 C-X-C motif chemokine ligand 8 Homo sapiens 4-8 34106437-5 2021 Progesterone stimulation decreased the expression of TLR2, TLR5, and Nod2 genes (alone and/or in combination with TLR/NLR agonists) and decreased the expression of IL-1beta and IL-8 genes increased by stimulation with specific agonists for TLR2, TLR4, TLR5, Nod1, and Nod2. Progesterone 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 177-181 1347804-4 1992 Choriodecidual cells in culture produced substantial amounts of interleukin-8; release was inhibited by progesterone and stimulated by the antiprogestagen mifepristone. Progesterone 104-116 C-X-C motif chemokine ligand 8 Homo sapiens 64-77 34106437-6 2021 Moreover, progesterone decreased thrombin-induced IL-8 gene expression. Progesterone 10-22 C-X-C motif chemokine ligand 8 Homo sapiens 50-54