PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11511305-0	2001	17beta-estradiol, progesterone, and dihydrotestosterone suppress the growth of human melanoma by inhibiting interleukin-8 production.	Progesterone	18-30	C-X-C motif chemokine ligand 8	Homo sapiens	108-121	
15943769-4	2005	The production of vascular endothelial growth factor (VEGF), interleukin (IL)-6 and IL-8 by HGF increased following stimulation with estradiol or progesterone, at concentrations comparable to those present in the plasma of pregnant women.	Progesterone	146-158	C-X-C motif chemokine ligand 8	Homo sapiens	84-88	
11912286-7	2002	The immunoreactive levels of endometrial IL-8 and MCP-1 were up-regulated by the administration of progesterone during the receptive phase of the cycle.	Progesterone	99-111	C-X-C motif chemokine ligand 8	Homo sapiens	41-45	
15613411-8	2005	The effects of estradiol (5 x 10(-8) m), progesterone (10(-7) m), or both on IL-8 mRNA and protein levels were analyzed by RT-PCR and ELISA, respectively.	Progesterone	41-53	C-X-C motif chemokine ligand 8	Homo sapiens	77-81	
12672669-0	2003	Progesterone represses interleukin-8 and cyclo-oxygenase-2 in human lower segment fibroblast cells and amnion epithelial cells.	Progesterone	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	23-36	
11511305-11	2001	These data suggest that 17beta-estradiol, progesterone, and dihydrotestosterone suppress the growth of melanoma by inhibiting interleukin-8 production in a receptor-dependent manner.	Progesterone	42-54	C-X-C motif chemokine ligand 8	Homo sapiens	126-139	
10076137-5	1999	RESULTS: Interleukin 8 release from cervical explants was stimulated by prostaglandin E2 and nitric oxide and inhibited by progesterone and dexamethasone.	Progesterone	123-135	C-X-C motif chemokine ligand 8	Homo sapiens	9-22	
10404837-6	1999	Midluteal endometrium showed minimal IL-8 expression, whereas endometrium obtained from women administered progesterone for 4 days from (LH peak + 8 days), to simulate luteal regression, demonstrated significantly increased localization of IL-8 mRNA, 48 h after withdrawal of progesterone.	Progesterone	107-119	C-X-C motif chemokine ligand 8	Homo sapiens	240-244	
21356375-7	2011	IL-8 was increased by PGE(2) and hypoxia in secretory but not proliferative explants, which suggests that exposure to progesterone is essential.	Progesterone	118-130	C-X-C motif chemokine ligand 8	Homo sapiens	0-4	
9920091-1	1999	The role of progesterone (P4) in the regulation of inflammatory mediators interleukin-8 (IL-8), monocyte chemoattractant protein-1, and cyclooxygenase-2 (COX-2) and in the recruitment of leukocyte subpopulations in the endometrium has been examined, by employing a model of P4 withdrawal and maintenance in vivo.	Progesterone	12-24	C-X-C motif chemokine ligand 8	Homo sapiens	74-87	
9920091-1	1999	The role of progesterone (P4) in the regulation of inflammatory mediators interleukin-8 (IL-8), monocyte chemoattractant protein-1, and cyclooxygenase-2 (COX-2) and in the recruitment of leukocyte subpopulations in the endometrium has been examined, by employing a model of P4 withdrawal and maintenance in vivo.	Progesterone	12-24	C-X-C motif chemokine ligand 8	Homo sapiens	89-93	
8027281-6	1994	The IL-8 produced in uterine tissues might act synergistically with prostaglandin E (PGE), a likely site for this interaction being blood vessels where PGE production is also repressed by progesterone.	Progesterone	188-200	C-X-C motif chemokine ligand 8	Homo sapiens	4-8	
32792990-6	2020	In subsequent dose response studies, medroxyprogesterone acetate, but not progesterone, at doses of 10-6-10-8 M inhibited interleukin-1beta induced interleukin-8 and matrix metalloproteinase 1 mRNA expression.	Progesterone	44-56	C-X-C motif chemokine ligand 8	Homo sapiens	148-161	
29236553-5	2018	lipopolysaccharide co-treatment with progesterone significantly decreased the bacterial endotoxin-induced IL-1beta, TNF-alpha, IL-6, IL-8, and MIP-1alpha secretion.	Progesterone	37-49	C-X-C motif chemokine ligand 8	Homo sapiens	133-137	
27542947-19	2016	In co-culture, IL8 secretion was also suppressed on luteal phase day 15 (P = 0.013) versus follicular phase day 7, but IL8 secretion increased continuously under high E2/progesterone treatment (P = 0.003 for D13 versus D3).	Progesterone	170-182	C-X-C motif chemokine ligand 8	Homo sapiens	119-122	
26446923-9	2015	In comparison to the explants treated only with LPS, pre-treatment with 0.01-1.0 muM progesterone significantly blunted (73, 56, 56, 75, 25, 48 %) the secretion of TNF-alpha, IL-1beta, IL-6, IL-8, MIP-1alpha, IL-10, respectively.	Progesterone	85-97	C-X-C motif chemokine ligand 8	Homo sapiens	191-195	
24581581-10	2014	In marginal structural models, IL-1beta, IL-6, IL-8 were associated with lower estradiol and progesterone concentrations.	Progesterone	93-105	C-X-C motif chemokine ligand 8	Homo sapiens	47-51	
24128422-2	2014	We investigated the effect of lipopolysacharide (LPS) and progesterone (P4) upon expression of TLR-4/MyD88, TNFalpha, IL-6, IL-8, IL-10, and HBD2 on the human amniotic epithelium.	Progesterone	58-70	C-X-C motif chemokine ligand 8	Homo sapiens	124-128	
8756544-11	1996	Importantly, progesterone suppressed both basal and IL-1 alpha-stimulated IL-8 expression in stromal and granulosa-lutein cell types.	Progesterone	13-25	C-X-C motif chemokine ligand 8	Homo sapiens	74-78	
8027281-4	1994	In endometrium, the stage of the menstrual cycle did not affect IL-8 production but a 10(-6) M concentration of progesterone or dexamethasone significantly reduced the concentration of IL-8 in medium after 24 h. After a further 24 h with lipopolysaccharide (LPS) stimulation, only MPA and dexamethasone inhibited production significantly.	Progesterone	112-124	C-X-C motif chemokine ligand 8	Homo sapiens	185-189	
1347804-4	1992	Choriodecidual cells in culture produced substantial amounts of interleukin-8; release was inhibited by progesterone and stimulated by the antiprogestagen mifepristone.	Progesterone	104-116	C-X-C motif chemokine ligand 8	Homo sapiens	64-77	
34106437-5	2021	Progesterone stimulation decreased the expression of TLR2, TLR5, and Nod2 genes (alone and/or in combination with TLR/NLR agonists) and decreased the expression of IL-1beta and IL-8 genes increased by stimulation with specific agonists for TLR2, TLR4, TLR5, Nod1, and Nod2.	Progesterone	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	177-181	
34106437-6	2021	Moreover, progesterone decreased thrombin-induced IL-8 gene expression.	Progesterone	10-22	C-X-C motif chemokine ligand 8	Homo sapiens	50-54	
26321412-4	2015	IL-8 also promotes trophoblast cell migration and invasion, and stimulates the secretion of progesterone.	Progesterone	92-104	C-X-C motif chemokine ligand 8	Homo sapiens	0-4