PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6748648-4 1984 This increase corresponds to the reported increase in ultrafilterable cortisol, itself being presumably the result of the hypersection of progesterone characterizing this physiological condition since progesterone competes with cortisol not only at the level of transcortin but also at that of cytoplasmic glucocorticoid receptors. Progesterone 138-150 serpin family A member 6 Homo sapiens 262-273 2765544-1 1989 Transcortin complexed with progesterone was shown to bind specifically to the plasma membrane of human decidual endometrium. Progesterone 27-39 serpin family A member 6 Homo sapiens 0-11 2819107-3 1989 The sialoglycoprotein specifically binds transcortin complexed to progesterone with Kd approximately 10(-10) M. Progesterone 66-78 serpin family A member 6 Homo sapiens 41-52 2839166-1 1988 Corticosteroid-Binding globulin (CBG) is a plasma protein that binds certain steroid hormones, mainly cortisol and progesterone. Progesterone 115-127 serpin family A member 6 Homo sapiens 0-31 2839166-1 1988 Corticosteroid-Binding globulin (CBG) is a plasma protein that binds certain steroid hormones, mainly cortisol and progesterone. Progesterone 115-127 serpin family A member 6 Homo sapiens 33-36 3125170-9 1988 These results indicate a participation of steroid oxo groups in the binding of progesterone to transcortin. Progesterone 79-91 serpin family A member 6 Homo sapiens 95-106 3579210-5 1987 There was, however, a linear relationship between TBC and the progesterone + cortisol sum, such that a unit increase in TBC was accompanied by an approximate unit increase in the total concentration of the two main transcortin binding steroids. Progesterone 62-74 serpin family A member 6 Homo sapiens 215-226 6847866-4 1983 When 0.5 and 1 X 10(-6) M transcortin, which contained 1 and 2 X 10(-7) M cortisol as a transcortin-bound form, were added to 5 X 10(-6) M progesterone, greater suppression of thymidine incorporation was observed that than produced by progesterone alone (86.1% and 81.3 for 0.5 and 1 X 10(-6) M transcortin, respectively). Progesterone 139-151 serpin family A member 6 Homo sapiens 26-37 6883705-9 1983 Data obtained in ligand competition experiments for different steroid molecules suggest the similarity of the glucocorticoid- and progesterone-binding component found in 30% of BCF samples examined with the plasma corticosteroid-binding globulin (CBG, transcortin) and especially with the transcortin-like component detected in the whey of the human milk. Progesterone 130-142 serpin family A member 6 Homo sapiens 214-245 6883705-9 1983 Data obtained in ligand competition experiments for different steroid molecules suggest the similarity of the glucocorticoid- and progesterone-binding component found in 30% of BCF samples examined with the plasma corticosteroid-binding globulin (CBG, transcortin) and especially with the transcortin-like component detected in the whey of the human milk. Progesterone 130-142 serpin family A member 6 Homo sapiens 247-250 6883705-10 1983 It is suggested that the transcortin-like component may play an important role in controlling kinetics of transport and in regulating the effective levels of cortisol and progesterone in numerous breast cyst fluids. Progesterone 171-183 serpin family A member 6 Homo sapiens 25-36 6847866-5 1983 Moreover, when 5 X 10(-7) M transcortin containing the same amount of cortisol was added with 1, 2, and 5 X 10(-6) M progesterone, a greater suppression (92.6%, 74.1%, and 32.4% of control for 1, 2, and 5 x 10(-6) M progesterone) was demonstrated than that caused by progesterone alone (95.1%, 75.8%, and 49.5% of control for the corresponding concentrations of progesterone). Progesterone 117-129 serpin family A member 6 Homo sapiens 28-39 6847866-5 1983 Moreover, when 5 X 10(-7) M transcortin containing the same amount of cortisol was added with 1, 2, and 5 X 10(-6) M progesterone, a greater suppression (92.6%, 74.1%, and 32.4% of control for 1, 2, and 5 x 10(-6) M progesterone) was demonstrated than that caused by progesterone alone (95.1%, 75.8%, and 49.5% of control for the corresponding concentrations of progesterone). Progesterone 216-228 serpin family A member 6 Homo sapiens 28-39 6847866-5 1983 Moreover, when 5 X 10(-7) M transcortin containing the same amount of cortisol was added with 1, 2, and 5 X 10(-6) M progesterone, a greater suppression (92.6%, 74.1%, and 32.4% of control for 1, 2, and 5 x 10(-6) M progesterone) was demonstrated than that caused by progesterone alone (95.1%, 75.8%, and 49.5% of control for the corresponding concentrations of progesterone). Progesterone 216-228 serpin family A member 6 Homo sapiens 28-39 6847866-5 1983 Moreover, when 5 X 10(-7) M transcortin containing the same amount of cortisol was added with 1, 2, and 5 X 10(-6) M progesterone, a greater suppression (92.6%, 74.1%, and 32.4% of control for 1, 2, and 5 x 10(-6) M progesterone) was demonstrated than that caused by progesterone alone (95.1%, 75.8%, and 49.5% of control for the corresponding concentrations of progesterone). Progesterone 216-228 serpin family A member 6 Homo sapiens 28-39 6180581-6 1982 Progesterone showed a similar multicomponent interaction but differed from DHP in the extent of binding to CBG. Progesterone 0-12 serpin family A member 6 Homo sapiens 107-110 7074030-4 1982 The two monomeric CBG species were separated by preparative gel electrophoresis and were found to bind cortisol, as well as progesterone, with equal affinity. Progesterone 124-136 serpin family A member 6 Homo sapiens 18-21 7158414-2 1982 Ioglycamide was found to cause a decrease in the association constants for the binding of progesterone to both albumin and transcortin. Progesterone 90-102 serpin family A member 6 Homo sapiens 123-134 7284504-4 1981 In newborns with RDS, serum transcortin (binding progesterone) was close to the normal value, but serum progesterone concentration 57% below normal. Progesterone 49-61 serpin family A member 6 Homo sapiens 28-39 7306509-4 1981 The equilibrium association constants of the CBG complexes with cortisol and progesterone show a relatively broad pH maximum between pH 8 and 11. Progesterone 77-89 serpin family A member 6 Homo sapiens 45-48 7306509-8 1981 The association of cortisol and progesterone to human CBG at 4 and 37 degrees C is enthalpy driven, compensating for the unfavorable change in entropy. Progesterone 32-44 serpin family A member 6 Homo sapiens 54-57 588587-1 1977 The binding site of transcortin has been studied by using bromoacetyltestosterone and bromoacetylated derivatives of progesterone which were monohydroxylated at different positions of the steroid nucleus. Progesterone 117-129 serpin family A member 6 Homo sapiens 20-31 19591833-1 2009 In birds, corticosteroid-binding globulin (CBG) binds corticosterone, progesterone and testosterone. Progesterone 70-82 serpin family A member 6 Homo sapiens 10-41 182694-1 1976 A corticosteroid-binding protein was detected in the whey of human colostrum and milk which resembles serum corticosteroid-binding globulin in certain respects: the equilibrium association constants for cortisol and progesterone binding and the apparent molecular size, as determined by Sephadex G-200 chromatography, were similar, and cortisol andd progesterone competed strongly for binding to the same site in each instance. Progesterone 216-228 serpin family A member 6 Homo sapiens 108-139 182694-1 1976 A corticosteroid-binding protein was detected in the whey of human colostrum and milk which resembles serum corticosteroid-binding globulin in certain respects: the equilibrium association constants for cortisol and progesterone binding and the apparent molecular size, as determined by Sephadex G-200 chromatography, were similar, and cortisol andd progesterone competed strongly for binding to the same site in each instance. Progesterone 350-362 serpin family A member 6 Homo sapiens 108-139 4388444-0 1969 Influence of transcortin and albumin on the rate of reduction of progesterone on human placental 20-alpha-hydroxysteroid dehydrogenase. Progesterone 65-77 serpin family A member 6 Homo sapiens 13-24 32502768-0 2020 High binding site occupancy of corticosteroid-binding globulin by progesterone increases fetal free cortisol concentrations. Progesterone 66-78 serpin family A member 6 Homo sapiens 31-62 32502768-2 2020 CBG also has substantial progesterone binding affinity, 3-fold less than cortisol. Progesterone 25-37 serpin family A member 6 Homo sapiens 0-3 32502768-14 2020 CONCLUSION: In a manner unique to fetal life, very high progesterone concentrations are capable of elevating free cortisol concentrations through competition with cortisol at CBG"s hormone binding site, without altered binding affinity through CBG cleavage or altered CBG hormone-binding affinity. Progesterone 56-68 serpin family A member 6 Homo sapiens 175-178 32502768-15 2020 High circulating fetal progesterone concentrations compete for CBG binding with cortisol, leading to a 3-fold increase in the free cortisol fraction in cord blood. Progesterone 23-35 serpin family A member 6 Homo sapiens 63-66 32502768-17 2020 This mechanism may underlie the known association between cortisol, progesterone and CBG, and be relevant principally in the fetal circulation due to the high progesterone concentrations encountered. Progesterone 68-80 serpin family A member 6 Homo sapiens 85-88 29264477-10 2017 Speculatively, increased circulating haCBG concentrations in pregnancy may provide an increased reservoir of CBG-bound cortisol to prepare for the risk of puerperal infection or allow for cortisol binding in the face of competition from increased circulating progesterone concentrations. Progesterone 259-271 serpin family A member 6 Homo sapiens 39-42 24237147-2 2013 The substitution of the progesterone 3-oxo group for a 3-O-methoxyimino group was shown to diminish the affinity of the steroid for transcortin by approximately one order of magnitude irrespective of the substituent"s orientation. Progesterone 24-36 serpin family A member 6 Homo sapiens 132-143 23300763-1 2012 Corticosteroid-binding globulin (CBG) transports glucocorticoids and progesterone in the blood and thereby modulates the tissue availability of these hormones. Progesterone 69-81 serpin family A member 6 Homo sapiens 0-31 23300763-1 2012 Corticosteroid-binding globulin (CBG) transports glucocorticoids and progesterone in the blood and thereby modulates the tissue availability of these hormones. Progesterone 69-81 serpin family A member 6 Homo sapiens 33-36 23300763-5 2012 In the 2.5 A crystal structure of human CBG in complex with progesterone, the RCL is cleaved at a novel site that differs from the known human neutrophil elastase recognition site. Progesterone 60-72 serpin family A member 6 Homo sapiens 40-43 23300763-7 2012 The atomic interactions observed between progesterone and CBG explain the lower affinity of progesterone in comparison to corticosteroids. Progesterone 41-53 serpin family A member 6 Homo sapiens 58-61 23300763-7 2012 The atomic interactions observed between progesterone and CBG explain the lower affinity of progesterone in comparison to corticosteroids. Progesterone 92-104 serpin family A member 6 Homo sapiens 58-61 20631013-4 2010 This mechanism has been noted to be temperature responsive, and we have now investigated the effects of temperature on the binding of human CBG to both cortisol and progesterone. Progesterone 165-177 serpin family A member 6 Homo sapiens 140-143 20631013-5 2010 METHODS: Recombinant human CBG was synthesized and used for binding studies with cortisol and progesterone between 34 and 43 C. Binding was monitored by recording the change in intrinsic protein fluorescence. Progesterone 94-106 serpin family A member 6 Homo sapiens 27-30 22932886-1 2012 Corticosteroid-binding globulin (CBG) is a high-affinity plasma protein that transports glucocorticoids and progesterone. Progesterone 108-120 serpin family A member 6 Homo sapiens 0-31 22932886-1 2012 Corticosteroid-binding globulin (CBG) is a high-affinity plasma protein that transports glucocorticoids and progesterone. Progesterone 108-120 serpin family A member 6 Homo sapiens 33-36 19591833-1 2009 In birds, corticosteroid-binding globulin (CBG) binds corticosterone, progesterone and testosterone. Progesterone 70-82 serpin family A member 6 Homo sapiens 43-46 19591833-3 2009 Thus, an increase in corticosterone or progesterone may displace testosterone bound to CBG, leading to an increase in bioactive free testosterone levels without affecting total testosterone levels in the circulation. Progesterone 39-51 serpin family A member 6 Homo sapiens 87-90 19011238-1 2009 Corticosteroid-binding globulin (CBG) is a non-inhibitory serine proteinase inhibitor (serpin) that transports cortisol and progesterone in blood. Progesterone 124-136 serpin family A member 6 Homo sapiens 0-31 19011238-1 2009 Corticosteroid-binding globulin (CBG) is a non-inhibitory serine proteinase inhibitor (serpin) that transports cortisol and progesterone in blood. Progesterone 124-136 serpin family A member 6 Homo sapiens 33-36 11207196-5 2001 The steroid environment of the CBG in I differed greatly from that in the peripheral maternal and fetal circulations, because the progesterone:cortisol molar ratio in I was 75-fold higher than that in M and 7- to 10-fold higher than that in the fetal circulation. Progesterone 130-142 serpin family A member 6 Homo sapiens 31-34 14871264-2 2004 The protein component that is responsible for the AR-inducing activity of human follicular fluid, has been found to be immunologically identical with corticosteroid-binding globulin (CBG), which is well characterized and serves as a transport protein for progesterone and cortisol in the plasma. Progesterone 255-267 serpin family A member 6 Homo sapiens 150-181 14871264-2 2004 The protein component that is responsible for the AR-inducing activity of human follicular fluid, has been found to be immunologically identical with corticosteroid-binding globulin (CBG), which is well characterized and serves as a transport protein for progesterone and cortisol in the plasma. Progesterone 255-267 serpin family A member 6 Homo sapiens 183-186 17029948-1 2006 Corticosteroid-binding globulin (CBG) is a plasma glycoprotein that is primarily synthesized in the liver and binds cortisol and progesterone with high affinity. Progesterone 129-141 serpin family A member 6 Homo sapiens 0-31 17029948-1 2006 Corticosteroid-binding globulin (CBG) is a plasma glycoprotein that is primarily synthesized in the liver and binds cortisol and progesterone with high affinity. Progesterone 129-141 serpin family A member 6 Homo sapiens 33-36 11207196-8 2001 These data reflect the physiological relevance of the CBG-steroid interaction, especially with very CBG-loaded progesterone at the fetomaternal interface during late pregnancy. Progesterone 111-123 serpin family A member 6 Homo sapiens 54-57 11207196-8 2001 These data reflect the physiological relevance of the CBG-steroid interaction, especially with very CBG-loaded progesterone at the fetomaternal interface during late pregnancy. Progesterone 111-123 serpin family A member 6 Homo sapiens 100-103 9768330-3 1998 Furthermore, a high dose of progesterone or medroxyprogesterone acetate (MPA) suppressed CBG mRNA expression to a greater degree than did chlormadinone acetate or 17 alpha-hydroxyprogesterone caproate with or without E2. Progesterone 28-40 serpin family A member 6 Homo sapiens 89-92 10436419-7 1999 These data suggest that human normal ovaries and ovarian cancers might synthesize CBG intracellularly, ovarian cancers might conserve a progesterone-associated property via CBG, and the regulation of intracelluar CBG expression might be changed in some cancers. Progesterone 136-148 serpin family A member 6 Homo sapiens 173-176 10436419-7 1999 These data suggest that human normal ovaries and ovarian cancers might synthesize CBG intracellularly, ovarian cancers might conserve a progesterone-associated property via CBG, and the regulation of intracelluar CBG expression might be changed in some cancers. Progesterone 136-148 serpin family A member 6 Homo sapiens 173-176 10399051-5 1999 On the other hand, CBG mRNA level was positively correlated with serum estradiol-17 beta and progesterone level (p < 0.01 and p < 0.01, respectively). Progesterone 93-105 serpin family A member 6 Homo sapiens 19-22 8213224-3 1993 The serum levels of SHBG and CBG increased during treatment and a weak association between progesterone dosage and CBG was observed. Progesterone 91-103 serpin family A member 6 Homo sapiens 115-118 8540288-1 1995 This study was designed to investigate the biological significance in intracellular expression of sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) mRNA in uterine endometrium with luteal phase deficiency (designated as out-of-phase endometrium or low serum progesterone level). Progesterone 286-298 serpin family A member 6 Homo sapiens 171-174 8540288-4 1995 On the other hand, SHBG and CBG mRNA levels in the endometria of low serum midluteal progesterone level were significantly (p < 0.05) reduced and raised, respectively, compared with normal levels. Progesterone 85-97 serpin family A member 6 Homo sapiens 28-31 8540288-5 1995 These findings suggest that the synthesis of endometrial steroid-binding proteins in the out-of-phase endometrium is conserved, as that in the in-phase endometrium, whereas the decreased progesterone level might up-regulate CBG expression with down-regulation of SHBG expression. Progesterone 187-199 serpin family A member 6 Homo sapiens 224-227 9472947-12 1998 Endometrial CBG-like binding activity could mediate actions of cortisol or progesterone on uterine function. Progesterone 75-87 serpin family A member 6 Homo sapiens 12-15 7878688-1 1994 Corticosteroid-binding globulin (CBG or transcortin) is a specific plasma glycoprotein, which binds steroid hormones (cortisol, corticosterone, and progesterone), and plays a role in transporting these steroids, altering their concentrations in blood, and influencing their biological actions. Progesterone 148-160 serpin family A member 6 Homo sapiens 0-31 7878688-1 1994 Corticosteroid-binding globulin (CBG or transcortin) is a specific plasma glycoprotein, which binds steroid hormones (cortisol, corticosterone, and progesterone), and plays a role in transporting these steroids, altering their concentrations in blood, and influencing their biological actions. Progesterone 148-160 serpin family A member 6 Homo sapiens 33-36 7878688-1 1994 Corticosteroid-binding globulin (CBG or transcortin) is a specific plasma glycoprotein, which binds steroid hormones (cortisol, corticosterone, and progesterone), and plays a role in transporting these steroids, altering their concentrations in blood, and influencing their biological actions. Progesterone 148-160 serpin family A member 6 Homo sapiens 40-51 7878688-5 1994 In the secretory phase, the endometrial CBG mRNA level was negatively correlated with the serum progesterone level (P < 0.01). Progesterone 96-108 serpin family A member 6 Homo sapiens 40-43 7878688-6 1994 While there was no positive correlation between the levels of endometrial CBG mRNA and serum estradiol (E2), there was a positive correlation between the endometrial CBG mRNA level and the serum E2/progesterone ratio (P < 0.05). Progesterone 198-210 serpin family A member 6 Homo sapiens 166-169 1659892-4 1991 It was found to have a subunit structure, with a homooligomeric sialoglycoprotein consisting of four 20 kDa protomeric species being involved in the recognition of the CBG molecules complexed with progesterone or cortisol. Progesterone 197-209 serpin family A member 6 Homo sapiens 168-171 1862072-1 1991 Human corticosteroid binding globulin (hCBG) is a 50- to 55-kDa serum glycoprotein that binds cortisol and progesterone with high affinity. Progesterone 107-119 serpin family A member 6 Homo sapiens 39-43 8419363-1 1993 Human corticosteroid binding-globulin (CBG) is a plasma glycoprotein that binds and regulates the biological activity of glucocorticoids and progesterone. Progesterone 141-153 serpin family A member 6 Homo sapiens 6-37 8419363-1 1993 Human corticosteroid binding-globulin (CBG) is a plasma glycoprotein that binds and regulates the biological activity of glucocorticoids and progesterone. Progesterone 141-153 serpin family A member 6 Homo sapiens 39-42