PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28434777-4 2017 Previously, our group identified the heat shock protein 60 (HSP60) as part of mitochondrial contact sites in human placenta, suggesting its participation in progesterone synthesis. Progesterone 157-169 heat shock protein family D (Hsp60) member 1 Homo sapiens 37-58 28434777-4 2017 Previously, our group identified the heat shock protein 60 (HSP60) as part of mitochondrial contact sites in human placenta, suggesting its participation in progesterone synthesis. Progesterone 157-169 heat shock protein family D (Hsp60) member 1 Homo sapiens 60-65 28434777-5 2017 Here, we examined the role of HSP60 in progesterone synthesis. Progesterone 39-51 heat shock protein family D (Hsp60) member 1 Homo sapiens 30-35 28434777-6 2017 Our results show that over-expression of HSP60 in human placental choriocarcinoma cells (JEG-3) and human embryonic kidney 293 cells (HEK293) promotes progesterone synthesis. Progesterone 151-163 heat shock protein family D (Hsp60) member 1 Homo sapiens 41-46 28434777-7 2017 Furthermore, incubation of the HSP60 recombinant protein with intact isolated mitochondria from JEG-3 cells also promotes progesterone synthesis in a dose-related fashion. Progesterone 122-134 heat shock protein family D (Hsp60) member 1 Homo sapiens 31-36 28434777-10 2017 Ours results demonstrate that HSP60 participates in mitochondrial progesterone synthesis. Progesterone 66-78 heat shock protein family D (Hsp60) member 1 Homo sapiens 30-35