PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26989199-4 2016 We show that ABHD2 is highly expressed in spermatozoa, binds progesterone, and acts as a progesterone-dependent lipid hydrolase by depleting the endocannabinoid 2-arachidonoylglycerol (2AG) from plasma membrane. Progesterone 61-73 abhydrolase domain containing 2, acylglycerol lipase Homo sapiens 13-18 26989199-6 2016 This study reveals that progesterone-activated endocannabinoid depletion by ABHD2 is a general mechanism by which progesterone exerts its genome-independent action and primes sperm for fertilization. Progesterone 24-36 abhydrolase domain containing 2, acylglycerol lipase Homo sapiens 76-81 33752482-0 2021 Progesterone activates the cyclic AMP-protein kinase A signalling pathway by upregulating ABHD2 in fertile men. Progesterone 0-12 abhydrolase domain containing 2, acylglycerol lipase Homo sapiens 90-95 33752482-1 2021 OBJECTIVE: This was a prospective study to investigate whether progesterone affects sperm activity by regulating the cyclic AMP-protein kinase A (cAMP-PKA) signalling pathway via alpha/beta hydrolase domain-containing protein 2 (ABHD2). Progesterone 63-75 abhydrolase domain containing 2, acylglycerol lipase Homo sapiens 179-227 33752482-1 2021 OBJECTIVE: This was a prospective study to investigate whether progesterone affects sperm activity by regulating the cyclic AMP-protein kinase A (cAMP-PKA) signalling pathway via alpha/beta hydrolase domain-containing protein 2 (ABHD2). Progesterone 63-75 abhydrolase domain containing 2, acylglycerol lipase Homo sapiens 229-234 33752482-4 2021 The expression of ABHD2 in the presence of progesterone was detected in all groups, and cAMP and PKA levels were detected by ELISA in fertile men after treatment with ABHD2 antibody and PKA inhibitor H-89, respectively. Progesterone 43-55 abhydrolase domain containing 2, acylglycerol lipase Homo sapiens 18-23 33752482-7 2021 Progesterone increased mRNA and protein levels of ABHD2 in healthy spermatozoa but not in spermatozoa from infertile men. Progesterone 0-12 abhydrolase domain containing 2, acylglycerol lipase Homo sapiens 50-55 33752482-8 2021 The levels of cAMP and PKA were increased by progesterone in healthy spermatozoa, and the progesterone-increased cAMP and PKA were decreased by ABHD2 antibody and H-89, respectively. Progesterone 90-102 abhydrolase domain containing 2, acylglycerol lipase Homo sapiens 144-149