PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23344959-3 2013 Activation of CatSper (by raising pHi or stimulating with progesterone) caused sustained [Ca(2+)]i elevation but did not induce hyperactivation, the whiplash-like behavior required for progression along the oviduct and penetration of the zona pellucida. Progesterone 58-70 cation channel sperm associated 1 Homo sapiens 14-21 23530196-5 2013 Here, by recording ionic currents from spermatozoa of an infertile CatSper-deficient patient, we demonstrate that CatSper is indeed the principal Ca(2+) channel of human spermatozoa, and that it is strongly potentiated by progesterone. Progesterone 222-234 cation channel sperm associated 1 Homo sapiens 67-74 23530196-6 2013 In addition, by recording CatSper currents from human epididymal and testicular spermatozoa, we show that CatSper sensitivity to progesterone arises early in sperm development and increases gradually to a peak when spermatozoa are ejaculated. Progesterone 129-141 cation channel sperm associated 1 Homo sapiens 26-33 23530196-6 2013 In addition, by recording CatSper currents from human epididymal and testicular spermatozoa, we show that CatSper sensitivity to progesterone arises early in sperm development and increases gradually to a peak when spermatozoa are ejaculated. Progesterone 129-141 cation channel sperm associated 1 Homo sapiens 106-113 23530196-7 2013 These results unambiguously establish an important role of CatSper channel in human sperm nongenomic progesterone signaling and demonstrate that the molecular mechanism responsible for activation of CatSper by progesterone arises early in sperm development concurrently with the CatSper channel itself. Progesterone 101-113 cation channel sperm associated 1 Homo sapiens 59-66 23530196-7 2013 These results unambiguously establish an important role of CatSper channel in human sperm nongenomic progesterone signaling and demonstrate that the molecular mechanism responsible for activation of CatSper by progesterone arises early in sperm development concurrently with the CatSper channel itself. Progesterone 210-222 cation channel sperm associated 1 Homo sapiens 59-66 23530196-7 2013 These results unambiguously establish an important role of CatSper channel in human sperm nongenomic progesterone signaling and demonstrate that the molecular mechanism responsible for activation of CatSper by progesterone arises early in sperm development concurrently with the CatSper channel itself. Progesterone 210-222 cation channel sperm associated 1 Homo sapiens 199-206 23530196-7 2013 These results unambiguously establish an important role of CatSper channel in human sperm nongenomic progesterone signaling and demonstrate that the molecular mechanism responsible for activation of CatSper by progesterone arises early in sperm development concurrently with the CatSper channel itself. Progesterone 210-222 cation channel sperm associated 1 Homo sapiens 199-206 23530196-3 2013 Although it has been suggested that progesterone-dependent Ca(2+) influx into human spermatozoa is primarily mediated by cationic channel of sperm (CatSper), the principal flagellar Ca(2+) channel of sperm, conclusive loss-of-function genetic evidence for activation of CatSper by progesterone has yet to be provided. Progesterone 36-48 cation channel sperm associated 1 Homo sapiens 148-155 23530196-3 2013 Although it has been suggested that progesterone-dependent Ca(2+) influx into human spermatozoa is primarily mediated by cationic channel of sperm (CatSper), the principal flagellar Ca(2+) channel of sperm, conclusive loss-of-function genetic evidence for activation of CatSper by progesterone has yet to be provided. Progesterone 36-48 cation channel sperm associated 1 Homo sapiens 270-277 23530196-4 2013 Moreover, it is not clear whether the responsiveness of CatSper to progesterone is an innate property of human spermatozoa or is acquired as the result of exposure to the seminal plasma. Progesterone 67-79 cation channel sperm associated 1 Homo sapiens 56-63 33589564-10 2021 In summary, progesterone-induced sperm release required both active CatSper channels and proteasomal degradation, suggesting that hyperactivation and proteolysis are vital parts of the mechanism by which sperm move from the oviduct reservoir to the site of fertilization. Progesterone 12-24 cation channel sperm associated 1 Homo sapiens 68-75 22354039-2 2012 In humans, CatSper is directly activated by progesterone and prostaglandins-female factors that stimulate Ca(2+) influx. Progesterone 44-56 cation channel sperm associated 1 Homo sapiens 11-18 21880255-0 2011 [Chemotaxis of spermatozoa is regulated by progesterone binding on calcium channel CATSPER]. Progesterone 43-55 cation channel sperm associated 1 Homo sapiens 83-90 21412338-5 2011 Here we show that progesterone activates the sperm-specific, pH-sensitive CatSper Ca(2+) channel. Progesterone 18-30 cation channel sperm associated 1 Homo sapiens 74-81 21412338-13 2011 The identification of CatSper channel blockers will greatly facilitate the study of Ca(2+) signalling in sperm and help to define further the physiological role of progesterone and CatSper. Progesterone 164-176 cation channel sperm associated 1 Homo sapiens 22-29 21412339-8 2011 By applying the patch-clamp technique to mature human spermatozoa, we found that nanomolar concentrations of progesterone dramatically potentiate CatSper, a pH-dependent Ca(2+) channel of the sperm flagellum. Progesterone 109-121 cation channel sperm associated 1 Homo sapiens 146-153 21412339-9 2011 We demonstrate that human CatSper is synergistically activated by elevation of intracellular pH and extracellular progesterone. Progesterone 114-126 cation channel sperm associated 1 Homo sapiens 26-33 21412339-10 2011 Interestingly, human CatSper can be further potentiated by prostaglandins, but apparently through a binding site other than that of progesterone. Progesterone 132-144 cation channel sperm associated 1 Homo sapiens 21-28 21441941-0 2011 The mystery is solved--CatSper is the principal calcium channel activated by progesterone in human spermatozoa. Progesterone 77-89 cation channel sperm associated 1 Homo sapiens 23-30 34381781-2 2021 Prime examples are progesterone and prostaglandin E1 that activate CatSper without involving classical nuclear and G protein-coupled receptors, respectively. Progesterone 19-31 cation channel sperm associated 1 Homo sapiens 67-74 34718225-0 2022 Steroidal Antagonists of Progesterone- and PGE1-Induced Activation of the Cation Channel of Sperm (CatSper). Progesterone 25-37 cation channel sperm associated 1 Homo sapiens 99-106 34718225-2 2022 As CatSper is potently activated by progesterone, we evaluated a range of steroids to define the structure-activity relationships for channel activation and found that CatSper is activated by a broad range of steroids with diverse structural modifications. Progesterone 36-48 cation channel sperm associated 1 Homo sapiens 3-10 34718225-2 2022 As CatSper is potently activated by progesterone, we evaluated a range of steroids to define the structure-activity relationships for channel activation and found that CatSper is activated by a broad range of steroids with diverse structural modifications. Progesterone 36-48 cation channel sperm associated 1 Homo sapiens 168-175 34718225-8 2022 Significance Statement The steroids medroxyprogesterone acetate, levonorgestrel and aldosterone selectively antagonize progesterone- and prostaglandin E1-induced calcium influx through the CatSper cation channel in human sperm. Progesterone 119-131 cation channel sperm associated 1 Homo sapiens 189-196 34325773-5 2021 An increase in intracellular pH and progesterone (P4) activate cation channels of spermatozoa (CatSper). Progesterone 36-48 cation channel sperm associated 1 Homo sapiens 95-102 32622245-0 2020 Pentachlorophenol inhibits CatSper function to compromise progesterone"s action on human sperm. Progesterone 58-70 cation channel sperm associated 1 Homo sapiens 27-34 35476800-3 2022 Studies have shown that the cation channel of sperm (CatSper), cAMP, cGMP, protein kinases, and tyrosine phosphorylation are involved in the nongenomic signalling of progesterone (P4) in sperm. Progesterone 166-178 cation channel sperm associated 1 Homo sapiens 53-60 31862909-9 2019 Progesterone increased sperm intracellular Ca2+, which was abrogated by blocking the sperm-specific Ca2+ channel CatSper with NNC 055-0396. Progesterone 0-12 cation channel sperm associated 1 Homo sapiens 113-120 32774306-3 2020 Methods: Direct effects of BADGE and the endogenous ligand of human CatSper, progesterone, on Ca2+ signaling in human and boar sperm cells were evaluated side-by-side using a Ca2+ fluorimetric assay measuring changes in intracellular Ca2+. Progesterone 77-89 cation channel sperm associated 1 Homo sapiens 68-75 32004625-8 2020 Additionally, 10 and 100 muM anethole decreased both basal and progesterone-increased tyrosine phosphorylation, [Ca2+]i, and the current of CATSPER, a cation channel of sperm predominant for Ca2+ influx. Progesterone 63-75 cation channel sperm associated 1 Homo sapiens 140-147 32926144-8 2020 The two plant triterpenoids, lupeol and pristimerin, were unable to inhibit progesterone-induced Ca2+-signals, whereas the CatSper inhibitor RU1968 strongly inhibited progesterone-induced Ca2+-signals. Progesterone 167-179 cation channel sperm associated 1 Homo sapiens 123-130 31862909-11 2019 An inhibitor of the non-genomic progesterone receptor that activates CatSper similarly blocked sperm release. Progesterone 32-44 cation channel sperm associated 1 Homo sapiens 69-76 31862909-12 2019 This is the first report indicating that release of sperm from the sperm reservoir is induced by progesterone action through CatSper channels. Progesterone 97-109 cation channel sperm associated 1 Homo sapiens 125-132 30936599-17 2019 The activity of CatSper and Hv1 channels are required for progesterone-induced ROS generation by NOX5 enzyme. Progesterone 58-70 cation channel sperm associated 1 Homo sapiens 16-23 30936599-0 2019 Inhibition of CatSper and Hv1 Channels and NOX5 Enzyme Affect Progesterone-Induced Increase of Intracellular Calcium Concentration and ROS Generation in Human Sperm. Progesterone 62-74 cation channel sperm associated 1 Homo sapiens 14-21 29697805-2 2018 SUMMARY ANSWER: Single cell analysis of progesterone-induced (CatSper-mediated) [Ca2+]i showed that reduced progesterone-sensitivity is a common feature of sperm from sub-fertile patients and is correlated with fertilization rate. Progesterone 40-52 cation channel sperm associated 1 Homo sapiens 62-69 29697805-2 2018 SUMMARY ANSWER: Single cell analysis of progesterone-induced (CatSper-mediated) [Ca2+]i showed that reduced progesterone-sensitivity is a common feature of sperm from sub-fertile patients and is correlated with fertilization rate. Progesterone 108-120 cation channel sperm associated 1 Homo sapiens 62-69 28938737-2 2017 SUMMARY ANSWER: hFF potently stimulates CatSper and increases [Ca2+]i, primarily due to high concentrations of progesterone, however, other components of hFF also contribute to [Ca2+]i signaling, including modulation of CatSper channel activity and inhibition of [Ca2+]i oscillations. Progesterone 111-123 cation channel sperm associated 1 Homo sapiens 40-47 28874401-3 2018 Multiple chemical UV filters have been shown to induce a Ca2+ influx through CatSper, thus mimicking the effect of progesterone on Ca2+ signaling. Progesterone 115-127 cation channel sperm associated 1 Homo sapiens 77-84 29398748-0 2018 Inhibition of the CatSper Channel and NOX5 Enzyme Activity Affects the Functions of the Progesterone-Stimulated Human Sperm. Progesterone 88-100 cation channel sperm associated 1 Homo sapiens 18-25 28938737-21 2017 WIDER IMPLICATIONS OF THE FINDINGS: This study directly demonstrates that hFF activates CatSper and establishes that the biologically important effects of hFF reflect, at least in part, action on this channel, primarily via progesterone. Progesterone 224-236 cation channel sperm associated 1 Homo sapiens 88-95 28938737-3 2017 WHAT IS KNOWN ALREADY: CatSper, the principal Ca2+ channel in spermatozoa, is progesterone-sensitive and essential for fertility. Progesterone 78-90 cation channel sperm associated 1 Homo sapiens 23-30 27583790-2 2016 We hypothesized that chemical UV filters may mimic the physiological action of progesterone on CatSper, thus affecting Ca2+ signaling in human sperm cells. Progesterone 79-91 cation channel sperm associated 1 Homo sapiens 95-102 28810916-4 2017 Furthermore, the Catsper channel is regulated by some physiological stimulants, such as progesterone, cyclic nucleotides (e.g., cAMP, cGMP), zona pellucida (ZP) glycoproteins and bovine serum albumin (BSA). Progesterone 88-100 cation channel sperm associated 1 Homo sapiens 17-24 28507119-6 2017 However, physiological concentrations of testosterone and hydrocortisone inhibited CatSper activation by progesterone. Progesterone 105-117 cation channel sperm associated 1 Homo sapiens 83-90 28507119-9 2017 Interestingly, both compounds competed with progesterone and pregnenolone sulfate and significantly reduced CatSper activation by either steroid. Progesterone 44-56 cation channel sperm associated 1 Homo sapiens 108-115 28507119-11 2017 These results indicate that (i) pregnenolone sulfate together with progesterone are the main steroids that activate CatSper and (ii) pristimerin and lupeol can act as contraceptive compounds by averting sperm hyperactivation, thus preventing fertilization. Progesterone 67-79 cation channel sperm associated 1 Homo sapiens 116-123 27583790-11 2016 Nine UV filters primarily activated CatSper and thereby mimicked the effect of progesterone. Progesterone 79-91 cation channel sperm associated 1 Homo sapiens 36-43 25983333-2 2015 SUMMARY ANSWER: CatSper1 expression is positively related to progressive and hyperactivated (HA) motility, [Ca(2+)]i responsiveness to progesterone but not the acrosome reaction (AR). Progesterone 135-147 cation channel sperm associated 1 Homo sapiens 16-24 27134080-9 2016 In fluorescence imaging with human sperm, we observed an increase in Cd(2+) influx potentiated by progesterone, a potent activator of CatSper. Progesterone 98-110 cation channel sperm associated 1 Homo sapiens 134-141 26453676-3 2015 WHAT IS KNOWN ALREADY: In human spermatozoa, Ca(2+) influx induced by progesterone is mediated by CatSper, a sperm-specific Ca(2+) channel. Progesterone 70-82 cation channel sperm associated 1 Homo sapiens 98-105 25983333-6 2015 CatSper1 expression was related to routine semen parameters, motility kinematic parameters and basal and progesterone-stimulated [Ca(2+)]i and the AR. Progesterone 105-117 cation channel sperm associated 1 Homo sapiens 0-8 25983333-14 2015 A significant positive correlation was found between CatSper1 protein expression and the increase of [Ca(2+)]i in response to progesterone (r = 0.36, P < 0.05, n = 40) but not with basal [Ca(2+)]i. Progesterone 126-138 cation channel sperm associated 1 Homo sapiens 53-61 24430778-0 2014 The CatSper calcium channel in human sperm: relation with motility and involvement in progesterone-induced acrosome reaction. Progesterone 86-98 cation channel sperm associated 1 Homo sapiens 4-11 24430778-1 2014 STUDY QUESTION: Does CatSper have a role in the achievement of human sperm motility and in the Progesterone (P)-induced acrosome reaction (AR)? Progesterone 95-107 cation channel sperm associated 1 Homo sapiens 21-28