PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21918635-11 2011 We found that estrogens, including estradiol and estrone, had a higher affinity for hPR A and B monomers in comparison with the dimer, hPR AB, and that of the endogenous progesterone ligand. Progesterone 170-182 S100 calcium binding protein A6 Homo sapiens 84-95 23913445-9 2013 Antagonism of the classical progesterone receptors by mifepristone revealed that the observed progesterone effects are transmitted through PR-A and PR-B. Progesterone 28-40 S100 calcium binding protein A6 Homo sapiens 139-143 22419721-5 2012 DESIGN: Effects of PR-A and PR-B on the capacity for progesterone to modulate gene expression was determined using an immortalized human myometrial cell line stably transfected with inducible PR-A and PR-B expression transgenes and conditioned to express various PR-A and PR-B levels. Progesterone 53-65 S100 calcium binding protein A6 Homo sapiens 192-196 22419721-7 2012 RESULTS: PR-A and PR-B were each transcriptionally active in response to progesterone and affected the expression of distinct gene cohorts. Progesterone 73-85 S100 calcium binding protein A6 Homo sapiens 9-13 22419721-4 2012 OBJECTIVE: Our objective was to determine how PR-A and PR-B regulate progesterone action in human myometrial cells and specifically the expression of genes encoding contraction-associated proteins and proinflammatory mediators. Progesterone 69-81 S100 calcium binding protein A6 Homo sapiens 46-50 22419721-5 2012 DESIGN: Effects of PR-A and PR-B on the capacity for progesterone to modulate gene expression was determined using an immortalized human myometrial cell line stably transfected with inducible PR-A and PR-B expression transgenes and conditioned to express various PR-A and PR-B levels. Progesterone 53-65 S100 calcium binding protein A6 Homo sapiens 19-23 22419721-5 2012 DESIGN: Effects of PR-A and PR-B on the capacity for progesterone to modulate gene expression was determined using an immortalized human myometrial cell line stably transfected with inducible PR-A and PR-B expression transgenes and conditioned to express various PR-A and PR-B levels. Progesterone 53-65 S100 calcium binding protein A6 Homo sapiens 192-196 19837932-8 2009 CONCLUSIONS: We demonstrated in this study that endogenous progesterone might counteract the induction of prostaglandin synthesis by cortisol via PRA transdominant repression of GR function, whereas high levels of progesterone might further inhibit the induction by cortisol via competitive binding to GR in human amnion fibroblasts. Progesterone 59-71 S100 calcium binding protein A6 Homo sapiens 146-149 19284643-1 2009 BACKGROUND: The mechanism that initiates human parturition has been proposed to be "functional progesterone withdrawal" whereby the 116 kDa B-isoform of the progesterone receptor (PR-B) switches in favour of the 94 kDa A-isoform (PR-A) in reproductive tissues. Progesterone 95-107 S100 calcium binding protein A6 Homo sapiens 230-234 19701771-7 2009 The effect of progesterone was reverted by the progesterone receptor (PR) antagonist RU-486 or following transfection with small interference RNA (siRNA) against both PRA and PRB isoforms. Progesterone 14-26 S100 calcium binding protein A6 Homo sapiens 167-170 18421469-7 2008 PR-A expression could be significantly upregulated with progesterone, again on mRNA and protein level. Progesterone 56-68 S100 calcium binding protein A6 Homo sapiens 0-4 19339781-0 2009 Effects of progesterone and its antagonist mifepristone on progesterone receptor a expression in human umbilical vein endothelial cells. Progesterone 11-23 S100 calcium binding protein A6 Homo sapiens 59-82 19339781-7 2009 Expression of PR-A could be significantly upregulated with progesterone and mifepristone. Progesterone 59-71 S100 calcium binding protein A6 Homo sapiens 14-18 19095059-9 2009 We observed that overexpression of PR-A significantly diminished the increase in U373 cells number produced after progesterone treatment. Progesterone 114-126 S100 calcium binding protein A6 Homo sapiens 35-39 17341556-4 2007 The capacity for PR-A and PR-B, alone and in combination, to mediate genomic progesterone responsiveness measured by the activity of a progesterone-responsive reporter plasmid was examined by artificially modulating their levels in the PHM1-31 myometrial cell line. Progesterone 77-89 S100 calcium binding protein A6 Homo sapiens 17-21 17893877-1 2008 It is known that progesterone receptor (PR) isoform A (PR-A) and isoform B (PR-B) may mediate different effects of progesterone. Progesterone 17-29 S100 calcium binding protein A6 Homo sapiens 55-59 17785366-9 2007 Transient transfection with deletion mutants of bcl-2 promoter showed that the -1281/-258-bp region conferred responsiveness to progesterone induction in the presence of PR-A. Progesterone 128-140 S100 calcium binding protein A6 Homo sapiens 170-174 17341556-8 2007 PR-A had no effect alone but markedly decreased PR-B-mediated progesterone responsiveness. Progesterone 62-74 S100 calcium binding protein A6 Homo sapiens 0-4 16985038-2 2006 The effects of progesterone may be mediated in part through the progesterone receptor, which exists in two functionally distinct protein isoforms, hPR-A and hPR-B. Progesterone 15-27 S100 calcium binding protein A6 Homo sapiens 147-152 14973372-6 2003 We demonstrate that the two PR isoforms, PR-A and PR-B, have mostly nonoverlapping molecular signatures when liganded by progesterone, with PR-B the more active form. Progesterone 121-133 S100 calcium binding protein A6 Homo sapiens 41-45 16384861-1 2006 Progesterone receptor (PR), a ligand-inducible transcription factor, mediates the physiological actions of progesterone (P) through two distinct isoforms, PR-A and PR-B, and numerous nuclear coregulators. Progesterone 107-119 S100 calcium binding protein A6 Homo sapiens 155-159 16442706-1 2006 Transcriptional regulation by progesterone is mediated primarily through the two progesterone receptor (PR) isoforms, PR-A and PR-B. Progesterone 30-42 S100 calcium binding protein A6 Homo sapiens 118-122 16254035-0 2006 The progesterone receptor in human term amniochorion and placenta is isoform C. The mechanism that initiates human parturition has been proposed to be functional progesterone withdrawal whereby the 116-kDa B isoform of the progesterone receptor (PR-B) switches in favor of the 94-kDa A isoform (PR-A) in reproductive tissues. Progesterone 4-16 S100 calcium binding protein A6 Homo sapiens 295-299 14667972-10 2003 Regulated differential expression of PR-A versus PR-B also appears to fine tune the effect of progesterone on specific genes. Progesterone 94-106 S100 calcium binding protein A6 Homo sapiens 37-41 17965625-1 2006 The physiological effects of progesterone (P) are mediated by two isoforms of progesterone receptors (PRs): PR-A and PR-B. Progesterone 29-41 S100 calcium binding protein A6 Homo sapiens 108-112 15520195-10 2004 Zymographic analysis revealed that Pg drastically inhibited matrix metalloproteinase-9 (MMP-9) activity in cells transfected with either PR-A or PR-B. Progesterone 35-37 S100 calcium binding protein A6 Homo sapiens 137-141 15280552-2 2004 In humans and other vertebrates, the biological activity of progesterone is mediated by modulation of the transcriptional activity of two progesterone receptors, PR-A and PR-B. Progesterone 60-72 S100 calcium binding protein A6 Homo sapiens 162-166 15120691-5 2004 As PR-A represses progesterone actions mediated by PR-B, the extent of progesterone responsiveness is inversely related to the PR-A/PR-B expression ratio. Progesterone 18-30 S100 calcium binding protein A6 Homo sapiens 3-7 15120691-5 2004 As PR-A represses progesterone actions mediated by PR-B, the extent of progesterone responsiveness is inversely related to the PR-A/PR-B expression ratio. Progesterone 18-30 S100 calcium binding protein A6 Homo sapiens 127-131 15120691-5 2004 As PR-A represses progesterone actions mediated by PR-B, the extent of progesterone responsiveness is inversely related to the PR-A/PR-B expression ratio. Progesterone 71-83 S100 calcium binding protein A6 Homo sapiens 3-7 15120691-5 2004 As PR-A represses progesterone actions mediated by PR-B, the extent of progesterone responsiveness is inversely related to the PR-A/PR-B expression ratio. Progesterone 71-83 S100 calcium binding protein A6 Homo sapiens 127-131 11500241-3 2001 In progesterone responsive tissues, the relative ratio of PR-A and PR-B is considered to contribute to the tissue-specific actions of progesterone. Progesterone 3-15 S100 calcium binding protein A6 Homo sapiens 58-62 12050275-2 2002 Instead, these events could be facilitated by changes in the responsiveness of the myometrium to progesterone and estrogens via changes in PR and ER expression. Progesterone 97-109 S100 calcium binding protein A6 Homo sapiens 139-141 12050275-9 2002 These data indicate that in the term human myometrium, responsiveness to progesterone is controlled by the expression of PR-A relative to PR-B and that a significant increase in this ratio underlies functional progesterone withdrawal. Progesterone 73-85 S100 calcium binding protein A6 Homo sapiens 121-125 11500241-3 2001 In progesterone responsive tissues, the relative ratio of PR-A and PR-B is considered to contribute to the tissue-specific actions of progesterone. Progesterone 134-146 S100 calcium binding protein A6 Homo sapiens 58-62 10548881-3 1999 In most cell lines, hPR-A functions as a transcriptional repressor of progesterone-responsive promoters, whereas hPR-B functions as a transcriptional activator of the same genes. Progesterone 70-82 S100 calcium binding protein A6 Homo sapiens 20-25 11117526-10 2000 The high transactivation capacity of hPR-A was also activated by other ligands, progesterone, Org 2058, and norethindrone. Progesterone 80-92 S100 calcium binding protein A6 Homo sapiens 37-42 10473602-8 1999 Using a luciferase reporter construct containing base pairs -252 to +24 of the IGFBP-5 promoter, we found that both PR(A) and PR(B) isoforms mediated PG stimulation of promoter activity. Progesterone 150-152 S100 calcium binding protein A6 Homo sapiens 116-121 9467558-5 1998 If this smaller PR species exhibits similar differences in function as have been evidenced in vitro for PR A relative to PR B, it is possible that this PR species may be an important component in determination of progesterone response in breast cancer. Progesterone 213-225 S100 calcium binding protein A6 Homo sapiens 104-108 9835356-6 1998 These findings suggest that human corpus luteum might intracellularly synthesize PR-A and PR-B, and thus be involved in the steroid functional regulation of the corpus luteum, especially at the early and mid secretory phases, and that progesterone might regulate the synthesis of PR-A and PR-B. Progesterone 235-247 S100 calcium binding protein A6 Homo sapiens 280-284 9467558-11 1998 In summary, this study has shown that a truncated PR protein, found in breast cancers, is ligand-binding and seems to be derived from PR A, indicating that it may have a role in progesterone signaling, although a deeper understanding of its role, if any, in breast cancer remains to be established. Progesterone 178-190 S100 calcium binding protein A6 Homo sapiens 134-138 9159448-1 1997 The two forms of the progesterone receptor, PR-A and PR-B, are independently regulated at the transcriptional level, and show distinct responses to progesterone antagonists. Progesterone 21-33 S100 calcium binding protein A6 Homo sapiens 44-48 9314568-12 1997 Since PR-B:PR-A can alter gene expression in response to progestins and antiprogestins in vitro, the temporal changes in PR-B:PR-A in the monkey corpus luteum may contribute to functional differences in luteal responses to progesterone and other steroids in vivo. Progesterone 223-235 S100 calcium binding protein A6 Homo sapiens 126-130 9408241-4 1997 Western blot analysis showed that progesterone or medroxyprogesterone acetate increased the two isoforms, PR-A and PR-B, in stromal cells but reduced them in glandular epithelial cells. Progesterone 34-46 S100 calcium binding protein A6 Homo sapiens 106-110 8387487-2 1993 Progesterone antagonists bind to two naturally occurring isoforms of human progesterone receptors (hPR), hPRB and the NH2-terminally truncated hPRA, and usually inhibit agonist-stimulated transcription. Progesterone 0-12 S100 calcium binding protein A6 Homo sapiens 143-147 8603052-2 1996 Two PR proteins, PR A (81-83 kDa) and PR B (116-120 kDa), have been described and different physiological activities ascribed to each on the basis of in vitro studies, suggesting that their ratio of expression may control progesterone responsiveness in target cells. Progesterone 222-234 S100 calcium binding protein A6 Homo sapiens 17-21 7969170-1 1994 The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B). Progesterone 27-39 S100 calcium binding protein A6 Homo sapiens 110-115 8163495-3 1994 Interestingly, in cell contexts where PR-A is transcriptionally inactive, it acts as a progesterone-dependent inhibitor of estrogen receptor function. Progesterone 87-99 S100 calcium binding protein A6 Homo sapiens 38-42 8387487-8 1993 When hPRA alone are transiently expressed in COS-1 cells, transcription of a reporter gene is stimulated by the agonist R5020 and by 8-Br-cAMP and is synergistic when both are present; but the 8-Br-cAMP-dependent component of transcription proceeds in the absence of hPRA, in the absence of the progesterone response element, and in the presence of a DNA-binding domain mutant of hPRA that cannot bind to the progesterone response element. Progesterone 295-307 S100 calcium binding protein A6 Homo sapiens 5-9 8387487-8 1993 When hPRA alone are transiently expressed in COS-1 cells, transcription of a reporter gene is stimulated by the agonist R5020 and by 8-Br-cAMP and is synergistic when both are present; but the 8-Br-cAMP-dependent component of transcription proceeds in the absence of hPRA, in the absence of the progesterone response element, and in the presence of a DNA-binding domain mutant of hPRA that cannot bind to the progesterone response element. Progesterone 409-421 S100 calcium binding protein A6 Homo sapiens 5-9 31435600-2 2019 Two progesterone receptor (PR) isoforms, namely PR-A and PR-B, mediate the special effects of progesterone. Progesterone 4-16 S100 calcium binding protein A6 Homo sapiens 48-52 34794738-9 2021 The finding of lower expression of PR-alpha in endometriotic nodule in our study may be related to decrease in progesterone effect which could not inhibit the decrease in the expression of T-cadherin and E-cadherin, thus the invasiveness of DIE tissue. Progesterone 111-123 S100 calcium binding protein A6 Homo sapiens 35-43 32302297-6 2020 These results suggest that the regulation of progesterone signaling by PR-A and PR-B may also have diverged in the human lineage and that non-human animal models of progesterone signaling may not faithfully recapitulate human biology. Progesterone 45-57 S100 calcium binding protein A6 Homo sapiens 71-75 1779977-4 1991 Moreover, as analyzed by gel-mobility shift, recombinant PR-A and PR-B each bound to specific progesterone response elements in a strictly hormone-dependent manner. Progesterone 94-106 S100 calcium binding protein A6 Homo sapiens 57-61 34224241-8 2021 High doses of progesterone increased the expression of Ki67 mRNA, while low doses increased the expression of PR-A mRNA in cultured leiomyoma cells and tissue explants. Progesterone 14-26 S100 calcium binding protein A6 Homo sapiens 110-114 32618512-8 2020 Further study showed that progesterone increased PR-A-SP1 complex formation and facilitated PR-A/B and SP1 binding to eNOS promoter. Progesterone 26-38 S100 calcium binding protein A6 Homo sapiens 92-98 30782101-3 2019 Progesterone plays crucial role in endometrial receptivity by acting through progesterone receptor (PGR) isoforms PR-A and PR-B whose expression is epigenetically regulated by DNA methylation, in a specific promoter region for each isoform. Progesterone 0-12 S100 calcium binding protein A6 Homo sapiens 114-118 31271717-3 2019 The role of progesterone and changes in the receptor status towards prevalence of PR-A with a decreased response of endometrial tissue to progesterone and inhibition of apoptosis are described. Progesterone 12-24 S100 calcium binding protein A6 Homo sapiens 82-86 27653036-1 2016 The hypothesis that phosphorylation of progesterone receptor (PR) isoforms, PR-A and PR-B, in myometrial cells affects progesterone action in the context of human parturition was tested. Progesterone 39-51 S100 calcium binding protein A6 Homo sapiens 76-80 27886516-4 2017 One mechanism for functional progesterone withdrawal is increased abundance of PR-A, which decreases progesterone responsiveness by inhibiting the transcriptional activity of PR-B. Progesterone 29-41 S100 calcium binding protein A6 Homo sapiens 79-83 27653036-5 2016 Prevention of pSer345 (by site-directed mutagenesis) abolished the capacity for PR-A to inhibit anti-inflammatory actions of progesterone mediated by PR-B but had no effect on the transrepressive activity of PR-A at a canonical progesterone response element. Progesterone 125-137 S100 calcium binding protein A6 Homo sapiens 80-84 25791399-8 2015 CONCLUSION: The results of the present study demonstrate that PRA could play an inhibitory role in the cell proliferation of PNETs, possibly by inhibiting PRB-mediated signals in the presence of progesterone, which could result in decreased CCND1 expression. Progesterone 195-207 S100 calcium binding protein A6 Homo sapiens 62-65 26037298-2 2015 Progesterone mediates its biological activity via the 2 progesterone receptor (PR) isoforms (PR-A and PR-B). Progesterone 0-12 S100 calcium binding protein A6 Homo sapiens 93-97 26037298-3 2015 Effects of progesterone are determined by the PR-A:PR-B ratio such that a PR-B-dominant state promotes progesterone signaling, whereas a PR-A-dominant state decreases progesterone responsiveness. Progesterone 11-23 S100 calcium binding protein A6 Homo sapiens 46-50 26037298-3 2015 Effects of progesterone are determined by the PR-A:PR-B ratio such that a PR-B-dominant state promotes progesterone signaling, whereas a PR-A-dominant state decreases progesterone responsiveness. Progesterone 11-23 S100 calcium binding protein A6 Homo sapiens 137-141 26037298-3 2015 Effects of progesterone are determined by the PR-A:PR-B ratio such that a PR-B-dominant state promotes progesterone signaling, whereas a PR-A-dominant state decreases progesterone responsiveness. Progesterone 103-115 S100 calcium binding protein A6 Homo sapiens 46-50