PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12142244-6	2002	IGFBPs have been detected in the CL of domestic animals, and inhibitory effects on IGF-I-stimulated progesterone production have been demonstrated.	Progesterone	100-112	IGFI	Bos taurus	83-88	
17976073-3	2007	Incubation of luteal tissue in vitro demonstrated stimulatory activity of LH and IGF-I, and to a greater degree IGF-II, on luteal progesterone synthesis.	Progesterone	130-142	IGFI	Bos taurus	81-86	
16648300-4	2006	In FSH plus IGF-I-treated granulosa cells obtained from small follicles, 300 ng/ml GDF-9 reduced (P < 0.05) progesterone production by 15% and 600 ng/ml GDF-9 completely blocked (P < 0.01) the IGF-I-induced increase in progesterone production.	Progesterone	111-123	IGFI	Bos taurus	12-17	
16648300-4	2006	In FSH plus IGF-I-treated granulosa cells obtained from small follicles, 300 ng/ml GDF-9 reduced (P < 0.05) progesterone production by 15% and 600 ng/ml GDF-9 completely blocked (P < 0.01) the IGF-I-induced increase in progesterone production.	Progesterone	225-237	IGFI	Bos taurus	12-17	
15956304-8	2005	In experiment 4, E2 (300 ng/mL) decreased IGF-I- and insulin-induced thecal cell progesterone production by 70 to 77%, whereas E2 increased basal, IGF-I, and insulin-induced androstenedione production.	Progesterone	81-93	IGFI	Bos taurus	42-47	
15501579-7	2004	In the absence of LH, 2-day treatment of IGF-I or -II had no effect on thecal androstenedione production but increased (P < 0.05) thecal progesterone production.	Progesterone	140-152	IGFI	Bos taurus	41-53	
15501579-8	2004	In the presence of LH, 100 ng/ml of IGF-I increased progesterone and androstenedione production to a greater degree than did 100 ng/ml of IGF-II.	Progesterone	52-64	IGFI	Bos taurus	36-41	
21315524-5	2011	In small-follicle granulosa cells, resistin attenuated the stimulatory effect of IGF-I on progesterone and estradiol production of small-follicle granulosa cells.	Progesterone	90-102	IGFI	Bos taurus	81-86	
16648300-8	2006	In FSH plus IGF-I-treated granulosa cells obtained from large follicles, GDF-9 caused a dose-dependent decrease (P<0.05) in IGF-I-induced progesterone (by 13-48%) and estradiol (by 20-51%) production.	Progesterone	141-153	IGFI	Bos taurus	12-17	
16648300-8	2006	In FSH plus IGF-I-treated granulosa cells obtained from large follicles, GDF-9 caused a dose-dependent decrease (P<0.05) in IGF-I-induced progesterone (by 13-48%) and estradiol (by 20-51%) production.	Progesterone	141-153	IGFI	Bos taurus	127-132	
16293942-10	2006	This improvement is probably due to prevention of premature increases of estradiol-17beta and progesterone concentrations, which occurred in cows with low IGF-I concentrations treated with Ovsynch, by the CIDR treatment.	Progesterone	94-106	IGFI	Bos taurus	155-160	
8838024-5	1996	In the absence of bFGF and the presence of LH, 30 ng/ml of IGF-I increased thecal cell numbers and production of androstenedione and progesterone.	Progesterone	133-145	IGFI	Bos taurus	59-64	
9166698-5	1997	A higher dose of IGF-I (i.e., 100 ng/ml) overcame the inhibitory effects of IGFBP-3 on IGF-I-induced cell proliferation and on progesterone and androstenedione production by thecal cells.	Progesterone	127-139	IGFI	Bos taurus	17-22	
12044613-8	2002	Insulin, IGF-I and FSH also increased (P<0.05) granulosa cell numbers and progesterone production but their maximal effects were less (i.e., < 4-fold increase) than their effects on estradiol production.	Progesterone	77-89	IGFI	Bos taurus	9-14	
8655449-7	1995	However, IGF-I and insulin increased (P < .05) androstenedione and progesterone production in the presence of LH.	Progesterone	70-82	IGFI	Bos taurus	9-14	
8655449-9	1995	The stimulatory effects of IGF-I on cell proliferation and progesterone production were not detected in the presence of 100 ng/mL insulin.	Progesterone	59-71	IGFI	Bos taurus	27-32	
2401866-2	1990	In this work, the regulation of granulosa and luteal cells by prostaglandins and insulin (or insulin-like growth factor-I; IGF-I) has been explored by comparing their effects on oxytocin and progesterone production in cell culture.	Progesterone	191-203	IGFI	Bos taurus	123-128