PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3257189-4 1988 Contrary to our expectation, IL-1 markedly inhibited the LH-stimulated progesterone production in a dose-dependent manner. Progesterone 71-83 interleukin 1 alpha Homo sapiens 29-33 3257189-6 1988 In addition to effects on LH-induced differentiation, IL-1 exhibited an inhibitory effect on basal (unstimulated) progesterone production as well. Progesterone 114-126 interleukin 1 alpha Homo sapiens 54-58 2826581-5 1987 Dex-mediated inhibition of IL-1 release appeared to be glucocorticoid receptor-mediated and was abrogated by progesterone. Progesterone 109-121 interleukin 1 alpha Homo sapiens 27-31 18628526-3 2008 However, the control by estradiol (E) and progesterone (P) of endometrial IL-1alpha expression and bioactivity remains unknown. Progesterone 42-54 interleukin 1 alpha Homo sapiens 74-83 32638280-10 2021 There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol. Progesterone 114-126 interleukin 1 alpha Homo sapiens 55-63 31176046-8 2019 Autophagy inhibitor 3-MA blocked the protective effects of PG in mediating NLRP3 inflammasome and IL-1beta processing. Progesterone 59-61 interleukin 1 alpha Homo sapiens 98-106 33278766-9 2021 Conversely, progesterone was negatively correlated with IL-1beta and several metabolites in the kynurenine pathway, including quinolinic acid. Progesterone 12-24 interleukin 1 alpha Homo sapiens 56-64 12226929-11 2002 Progesterone and 17 beta-estradiol downregulated costimulatory proliferative activity of IL-1 alpha or beta. Progesterone 0-12 interleukin 1 alpha Homo sapiens 89-99 10729317-3 2000 In humans, prostaglandin E(2) (PGE(2)) enhances while interleukin (IL)-1 inhibits the decidualizing effect of progesterone. Progesterone 110-122 interleukin 1 alpha Homo sapiens 54-72 11519352-4 2001 IL-1 has been considered as the inductor of several ovulation-associated events such as prostaglandin and progesterone biosynthesis, plasminogen activator production, glycosaminoglycan generation, and enhancement of vascular permeability. Progesterone 106-118 interleukin 1 alpha Homo sapiens 0-4 10770206-0 2000 Progesterone exposure prevents matrix metalloproteinase-3 (MMP-3) stimulation by interleukin-1alpha in human endometrial stromal cells. Progesterone 0-12 interleukin 1 alpha Homo sapiens 81-99 10770206-2 2000 Several laboratories have shown that inflammatory cytokines, including interleukin-lalpha (IL-1alpha), can oppose progesterone suppression of MMPs in the human endometrium. Progesterone 114-126 interleukin 1 alpha Homo sapiens 91-100 10770206-5 2000 Although IL-1alpha is a potent stimulator of MMP-3 in proliferative phase endometrium in organ culture, we demonstrate that progesterone exposure in vivo reduces IL-1alpha stimulation of MMP-3 in secretory phase tissue. Progesterone 124-136 interleukin 1 alpha Homo sapiens 162-171 10770206-6 2000 This loss of sensitivity to IL-1alpha was duplicated in isolated stromal cells treated with progesterone in vitro, and IL-1alpha stimulation of MMP-3 returned in a dose-dependent manner with progesterone withdrawal. Progesterone 92-104 interleukin 1 alpha Homo sapiens 28-37 8548848-6 1996 After 6 hr stimulation with IL-1 alpha suppression of E-selectin was observed with progesterone (P < 0.001). Progesterone 83-95 interleukin 1 alpha Homo sapiens 28-38 10440637-15 1999 CONCLUSIONS: Estradiol and progesterone inhibited the production of IL-1 from human peripheral monocytes. Progesterone 27-39 interleukin 1 alpha Homo sapiens 68-72 8756544-11 1996 Importantly, progesterone suppressed both basal and IL-1 alpha-stimulated IL-8 expression in stromal and granulosa-lutein cell types. Progesterone 13-25 interleukin 1 alpha Homo sapiens 52-62 8126130-15 1994 We conclude that monocyte IL-1 alpha, IL-1 beta, and TNF alpha may regulate trophoblast progesterone production through paracrine effects. Progesterone 88-100 interleukin 1 alpha Homo sapiens 26-36 7714166-1 1994 Interleukin-1 (IL-1) has been reported previously to inhibit the in-vitro decidualization of human endometrial stromal cells as assessed by progesterone-induced prolactin production and morphological transformation. Progesterone 140-152 interleukin 1 alpha Homo sapiens 0-13 8126130-9 1994 The monocyte cytokines [IL-1 alpha (5 U/mL), IL-1 beta (5 U/mL), and TNF alpha (1000 U/mL) significantly stimulated trophoblast progesterone production (nanograms per mL): JEG-3 control, 4.1 +/- 0.5; IL-1 alpha, 7.8 +/- 0.9; IL-1 beta, 8.8 +/- 0.5; and TNF alpha 7.2 +/- 0.8 (P < 0.05). Progesterone 128-140 interleukin 1 alpha Homo sapiens 24-34 8822445-0 1995 Interleukin-1 alpha and -beta modulation of luteinized human granulosa cell oestrogen and progesterone biosynthesis. Progesterone 90-102 interleukin 1 alpha Homo sapiens 0-19 8822445-1 1995 This study was designed to test the hypothesis that interleukin-1 alpha (IL-1 alpha) and beta directly affect progesterone, and oestradiol production in cultures of purified human granulosa cells. Progesterone 110-122 interleukin 1 alpha Homo sapiens 52-71 8822445-1 1995 This study was designed to test the hypothesis that interleukin-1 alpha (IL-1 alpha) and beta directly affect progesterone, and oestradiol production in cultures of purified human granulosa cells. Progesterone 110-122 interleukin 1 alpha Homo sapiens 73-83 8822445-5 1995 Our results indicate that progesterone synthesis by basal and human chorionic gonadotrophin (HCG)-stimulated granulosa cells co-cultured with white blood cells was inhibited by 5.0 ng/ml of IL-1 alpha and IL-1 beta at 48 h of culture. Progesterone 26-38 interleukin 1 alpha Homo sapiens 190-200 7714166-1 1994 Interleukin-1 (IL-1) has been reported previously to inhibit the in-vitro decidualization of human endometrial stromal cells as assessed by progesterone-induced prolactin production and morphological transformation. Progesterone 140-152 interleukin 1 alpha Homo sapiens 15-19 7714166-7 1994 These results indicated that TNF alpha and IL-1 suppress both progesterone-induced and cAMP-mediated prolactin production in endometrial stromal cells, and that this inhibition was not attributable to direct effects on progesterone metabolism or related to Ca(2+)-mediated signal transduction. Progesterone 62-74 interleukin 1 alpha Homo sapiens 43-47 8077304-1 1993 Interleukin-1 (IL-1), a potent stimulant of bone resorption, has been implicated in the pathogenesis of postmenopausal osteoporosis, because monocyte IL-1 bioactivity increases after the menopause and is decreased by estrogen and progesterone (EP) replacement. Progesterone 230-242 interleukin 1 alpha Homo sapiens 0-13 8077304-1 1993 Interleukin-1 (IL-1), a potent stimulant of bone resorption, has been implicated in the pathogenesis of postmenopausal osteoporosis, because monocyte IL-1 bioactivity increases after the menopause and is decreased by estrogen and progesterone (EP) replacement. Progesterone 230-242 interleukin 1 alpha Homo sapiens 15-19 1337276-10 1992 The stimulation of estradiol secretion and the inhibition of cell proliferation induced by IFN-alpha in cultured porcine granulosa cells in this study are in contrast with the effects of IL-1, which, as we reported previously, inhibited both progesterone and estradiol secretion and stimulated cell growth in these cell cultures. Progesterone 242-254 interleukin 1 alpha Homo sapiens 187-191 8508557-5 1993 Progesterone and testosterone at similar concentrations inhibited IL-1 secretion but had no significant effect on IL-6 secretion or on the production of cell-associated IL-1. Progesterone 0-12 interleukin 1 alpha Homo sapiens 66-70 8508557-8 1993 It is suggested that 17-beta-estradiol may promote IL-1 and IL-6 production and release, while gestation hormone, progesterone, and testosterone may inhibit IL-1 release in vivo. Progesterone 114-126 interleukin 1 alpha Homo sapiens 157-161 1522186-0 1992 The correlation of interleukin 1 and tumour necrosis factor to oestradiol, progesterone and testosterone levels in periovulatory follicular fluid of in-vitro fertilization patients. Progesterone 75-87 interleukin 1 alpha Homo sapiens 19-59 1291559-0 1992 Interactions between interferon gamma, tumour necrosis factor alpha, and interleukin-1 in modulating progesterone and oestradiol production by human luteinized granulosa cells in culture. Progesterone 101-113 interleukin 1 alpha Homo sapiens 73-86 1291559-6 1992 In addition, IL-1 and TNF alpha, neither of which was effective alone, acted synergistically to reduce significantly HCG-stimulated progesterone production by 30%. Progesterone 132-144 interleukin 1 alpha Homo sapiens 13-17 1522186-2 1992 The present study was performed in order to evaluate the correlation between interleukin 1 (IL-1) and tumour necrosis factor (TNF) concentrations in follicular fluid and its oestradiol, progesterone and testosterone levels. Progesterone 186-198 interleukin 1 alpha Homo sapiens 77-90 1522186-2 1992 The present study was performed in order to evaluate the correlation between interleukin 1 (IL-1) and tumour necrosis factor (TNF) concentrations in follicular fluid and its oestradiol, progesterone and testosterone levels. Progesterone 186-198 interleukin 1 alpha Homo sapiens 92-96 1522186-6 1992 There was a significant (P less than 0.01) positive correlation between IL-1 and progesterone levels. Progesterone 81-93 interleukin 1 alpha Homo sapiens 72-76 2378930-0 1990 Interleukin-1 alpha increases thecal progesterone production of preovulatory follicles in cyclic hamsters. Progesterone 37-49 interleukin 1 alpha Homo sapiens 0-19 1662225-4 1991 IL-1 alpha stimulated basal as well as LH-induced progesterone accumulation. Progesterone 50-62 interleukin 1 alpha Homo sapiens 0-10 2378930-2 1990 IL-1 alpha increased progesterone secretion by preovulatory follicles during a 24-h incubation in RPMI-1640 medium containing hCG (100 mIU/ml) (progesterone levels: 17.5 +/- 2.2 vs. 10.6 +/- 1.9 ng/follicle/ml, p less than 0.05). Progesterone 21-33 interleukin 1 alpha Homo sapiens 0-10 2378930-7 1990 IL-1 alpha at 5-50 U/ml maximally stimulated progesterone production in the preovulatory follicles, and no significant effect of IL-1 alpha was observed until the 12th hour of incubation. Progesterone 45-57 interleukin 1 alpha Homo sapiens 0-10 2378930-9 1990 IL-1 alpha in the presence of hCG also significantly increased progesterone secretion by atretic preovulatory follicles. Progesterone 63-75 interleukin 1 alpha Homo sapiens 0-10 2226666-6 1990 In a third study, IL-1 from untreated postmenopausal women was found to be higher than in either untreated premenopausal or estrogen/progesterone-treated postmenopausal women. Progesterone 133-145 interleukin 1 alpha Homo sapiens 18-22 2298860-3 1990 In addition, the production of IL-1 appears to be modulated by the gonadal estradiol and progesterone, leading to this study of IL-1 secretion by cultured peripheral monocytes isolated at varying times during the menstrual cycle and pregnancy. Progesterone 89-101 interleukin 1 alpha Homo sapiens 31-35 2298860-8 1990 Thus, peripheral monocyte IL-1 secretion appears to be increased by luteal levels of progesterone, although further elevation of progesterone during pregnancy returns IL-1 levels to the preovulatory baseline. Progesterone 85-97 interleukin 1 alpha Homo sapiens 26-30 2298860-8 1990 Thus, peripheral monocyte IL-1 secretion appears to be increased by luteal levels of progesterone, although further elevation of progesterone during pregnancy returns IL-1 levels to the preovulatory baseline. Progesterone 129-141 interleukin 1 alpha Homo sapiens 167-171 2298860-10 1990 Thus, IL-1 secretion from cultured monocytes appears to increase with luteal concentrations of progesterone and decrease to preovulatory levels at higher concentrations of the steroid during pregnancy, which may account for the dissociation of high progesterone levels and elevated basal body temperature during late pregnancy. Progesterone 95-107 interleukin 1 alpha Homo sapiens 6-10 2298860-10 1990 Thus, IL-1 secretion from cultured monocytes appears to increase with luteal concentrations of progesterone and decrease to preovulatory levels at higher concentrations of the steroid during pregnancy, which may account for the dissociation of high progesterone levels and elevated basal body temperature during late pregnancy. Progesterone 249-261 interleukin 1 alpha Homo sapiens 6-10 2544398-9 1989 These results indicate that the inhibitory effect of IL-1 on LH-stimulated progesterone secretion is due to its actions at at least two different sites along the LH-stimulated, cAMP-mediated, progesterone biosynthetic pathway, the LH receptor level and adenylate cyclase systems. Progesterone 75-87 interleukin 1 alpha Homo sapiens 53-57 2544398-9 1989 These results indicate that the inhibitory effect of IL-1 on LH-stimulated progesterone secretion is due to its actions at at least two different sites along the LH-stimulated, cAMP-mediated, progesterone biosynthetic pathway, the LH receptor level and adenylate cyclase systems. Progesterone 192-204 interleukin 1 alpha Homo sapiens 53-57 2783571-1 1989 Interleukin-1 (IL-1) significantly inhibited basal progesterone secretion and influenced the cell number in high density cultures of porcine granulosa cells harvested from small (1-2 mm) or medium (3-5 mm) follicles. Progesterone 51-63 interleukin 1 alpha Homo sapiens 0-13 2783571-1 1989 Interleukin-1 (IL-1) significantly inhibited basal progesterone secretion and influenced the cell number in high density cultures of porcine granulosa cells harvested from small (1-2 mm) or medium (3-5 mm) follicles. Progesterone 51-63 interleukin 1 alpha Homo sapiens 15-19 2783571-2 1989 These two effects of IL-1 showed similar but inverse dose-response relationships: Significant effects were observed at concentrations higher than 50 pg/ml, and the maximal effective concentration was 5 ng/ml, which reduced progesterone secretion by 53.5 +/- 2.1%. Progesterone 223-235 interleukin 1 alpha Homo sapiens 21-25 3146356-1 1988 Recombinant human interleukin-1 (IL-1) inhibits the follicle-stimulating hormone (FSH)-induced development of luteinizing hormone (LH) receptors and suppresses progesterone secretion in cultured rat granulosa cells. Progesterone 160-172 interleukin 1 alpha Homo sapiens 18-37 34106437-5 2021 Progesterone stimulation decreased the expression of TLR2, TLR5, and Nod2 genes (alone and/or in combination with TLR/NLR agonists) and decreased the expression of IL-1beta and IL-8 genes increased by stimulation with specific agonists for TLR2, TLR4, TLR5, Nod1, and Nod2. Progesterone 0-12 interleukin 1 alpha Homo sapiens 164-172 2787741-1 1989 Very recently, it has been reported that interleukin-1 (IL-1) has an inhibitory effect on progesterone production by porcine granulosa cells in vitro. Progesterone 90-102 interleukin 1 alpha Homo sapiens 41-54 2787741-1 1989 Very recently, it has been reported that interleukin-1 (IL-1) has an inhibitory effect on progesterone production by porcine granulosa cells in vitro. Progesterone 90-102 interleukin 1 alpha Homo sapiens 56-60 2522659-3 1989 IL-1 activity in the monocyte culture medium derived from untreated postmenopausal women (nonosteoporotic and osteoporotic) was higher than in the medium derived from either untreated premenopausal or estrogen/progesterone-treated postmenopausal women. Progesterone 210-222 interleukin 1 alpha Homo sapiens 0-4 2967196-1 1988 Interleukin-1 (IL-1), a monocyte and macrophage product, is the mediator of a wide variety of immune responses, including fever, and increases during the luteal phase of the menstrual cycle, concomitantly with progesterone (P). Progesterone 210-222 interleukin 1 alpha Homo sapiens 0-13 2967196-1 1988 Interleukin-1 (IL-1), a monocyte and macrophage product, is the mediator of a wide variety of immune responses, including fever, and increases during the luteal phase of the menstrual cycle, concomitantly with progesterone (P). Progesterone 210-222 interleukin 1 alpha Homo sapiens 15-19