PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7541943-1	1995	Recombinant human insulin-like growth factor binding protein-3 (rhIGFBP-3) effects on basal, insulin-like growth factor I (IGF-I)-, and follicle-stimulating hormone (FSH)-stimulated progesterone (P4) secretion and [3H]aminoisobutyric acid (AIB) uptake by primary porcine granulosa cells (MDGs) and MDGs that have been passaged once (MDGp1) were assessed.	Progesterone	182-194	insulin like growth factor binding protein 3	Homo sapiens	18-62	
7525255-15	1994	Although treatment with IGFBP-3 alone decreased both estrogen and progesterone production, cotreatment with IGFBP-3 and hCG resulted in a slight decrease in estrogen production but an increase in progesterone production.	Progesterone	66-78	insulin like growth factor binding protein 3	Homo sapiens	24-31	
7525255-15	1994	Although treatment with IGFBP-3 alone decreased both estrogen and progesterone production, cotreatment with IGFBP-3 and hCG resulted in a slight decrease in estrogen production but an increase in progesterone production.	Progesterone	196-208	insulin like growth factor binding protein 3	Homo sapiens	24-31	
7525255-15	1994	Although treatment with IGFBP-3 alone decreased both estrogen and progesterone production, cotreatment with IGFBP-3 and hCG resulted in a slight decrease in estrogen production but an increase in progesterone production.	Progesterone	196-208	insulin like growth factor binding protein 3	Homo sapiens	108-115	
7525259-6	1994	However, among healthy follicles (atretic follicles removed from analyses to better examine follicular maturation), IGFBP-3 increased (P < 0.01) between days 1 and 7 and was positively correlated with follicle diameter (r = 0.514; P < 0.05) and the FF concentration of progesterone (r = 0.556; P < 0.01), indicators of the degree of follicular maturation.	Progesterone	275-287	insulin like growth factor binding protein 3	Homo sapiens	116-123	
17492948-3	2007	This secondary analysis, based on a large randomized trial, aimed to estimate the effect of the route of administration of 17beta-oestradiol in combined hormone replacement therapy with progesterone on IGF-1 and IGFBP-3 levels.	Progesterone	186-198	insulin like growth factor binding protein 3	Homo sapiens	212-219	
7530723-7	1994	Significant (P < 0.05) effects were found at PGF2 alpha concentrations of 10(-8), 10(-7) and 10(-6) M. Because IGFBP-3 inhibits progesterone production stimulated by insulin-like growth factor (IGF)-I, the PGF2 alpha-induced stimulation of IGFBP-3 production may be one of the mechanisms whereby PGF2 alpha exerts its luteolytic effect via the IGF system.	Progesterone	131-143	insulin like growth factor binding protein 3	Homo sapiens	114-121	
16244494-2	2005	METHODS: We studied the action of leptin (0, 1, 10, or 100 ng/ml) and immunoneutralization of IGF-I using specific antiserum (0.1%) on the release of progesterone (P), estradiol (E), oxytocin (OT), IGF-I, IGFBP-3, and prostaglandins F (PGF) by these cells using radioimmunoassay/immunoradiometric assay.	Progesterone	150-162	insulin like growth factor binding protein 3	Homo sapiens	205-212	
15809018-2	2005	The aim of the present study was to investigate direct effects of estrogen (E2) or progesterone (P4) given separately vs. estrogen+progesterone on local IGF-I, IGFBP-3 and IGFBP-2 secretion.	Progesterone	83-95	insulin like growth factor binding protein 3	Homo sapiens	160-167	
15809018-5	2005	In hormone-dependent and hormone-independent tissues, treatment with estrogen+progesterone increased IGF-I and IGFBP-2 secretion with concomitant decrease in IGFBP-3, in the same manner as E2 or P4 given alone.	Progesterone	78-90	insulin like growth factor binding protein 3	Homo sapiens	158-165	
14674122-0	2003	The impact of progesterone on simultaneous, local secretion of IGFBP-3 and IGF-I [IGFBP-3/IGF-I index] by human malignant and non-malignant breast explants depends on tissue steroid receptor phenotype.	Progesterone	14-26	insulin like growth factor binding protein 3	Homo sapiens	63-70	
14674122-0	2003	The impact of progesterone on simultaneous, local secretion of IGFBP-3 and IGF-I [IGFBP-3/IGF-I index] by human malignant and non-malignant breast explants depends on tissue steroid receptor phenotype.	Progesterone	14-26	insulin like growth factor binding protein 3	Homo sapiens	82-89	
15629674-7	2005	Furthermore, expression of the main modulators of IGF action, the IGFBPs, was found to be regulated by estrogen and progesterone in both cell lines.	Progesterone	116-128	insulin like growth factor binding protein 3	Homo sapiens	66-72	
15629674-8	2005	IGFBP-4 was up-regulated by estrogen in the ECC-1 cell line, and IGFBP-3 and IGFBP-6 were down-regulated by progesterone in the PRAB-36 cell line.	Progesterone	108-120	insulin like growth factor binding protein 3	Homo sapiens	65-72