PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28651331-3 2017 By using cultured granulosa-lutein cells collected from women undergoing in vitro fertilization or intracytoplasmic sperm injection, we found that IL-1beta upregulated steroidogenic acute regulatory protein (StAR) expression and progesterone synthesis in granulosa-lutein cells, which was comparable with luteinizing hormone effect and could be abolished by an IL-1 receptor antagonist. Progesterone 229-241 steroidogenic acute regulatory protein Homo sapiens 208-212 26574040-4 2016 One consequence of such signaling within the GC layer is the initial capacity for steroidogenesis (predominantly progesterone production) mediated by increased expression of mRNA encoding steroidogenic acute regulatory protein (STAR) and the cholesterol side-chain cleavage enzyme (CYP11A). Progesterone 113-125 steroidogenic acute regulatory protein Homo sapiens 188-226 26574040-4 2016 One consequence of such signaling within the GC layer is the initial capacity for steroidogenesis (predominantly progesterone production) mediated by increased expression of mRNA encoding steroidogenic acute regulatory protein (STAR) and the cholesterol side-chain cleavage enzyme (CYP11A). Progesterone 113-125 steroidogenic acute regulatory protein Homo sapiens 228-232 26001835-0 2015 Activin A, B and AB decrease progesterone production by down-regulating StAR in human granulosa cells. Progesterone 29-41 steroidogenic acute regulatory protein Homo sapiens 72-76 24678481-3 2014 These rapid changes in StAR and Cyp19a1 gene expression after the LH surge efficiently facilitate progesterone production, which plays a crucial role in ovulation and the following luteinization. Progesterone 98-110 steroidogenic acute regulatory protein Homo sapiens 23-27 24140593-0 2013 BMP15 suppresses progesterone production by down-regulating StAR via ALK3 in human granulosa cells. Progesterone 17-29 steroidogenic acute regulatory protein Homo sapiens 60-64 22155568-0 2012 Luteinizing hormone (LH) regulates production of androstenedione and progesterone via control of histone acetylation of StAR and CYP17 promoters in ovarian theca cells. Progesterone 69-81 steroidogenic acute regulatory protein Homo sapiens 120-124 23200943-4 2013 First, we examined the expression of genes encoding proteins associated with progesterone biosynthesis: steroidogenic acute regulatory protein (STAR); a side chain cleavage enzyme (CYP11A1); and 3beta-hydroxysteroid dehydrogenase/ketosteroid isomerase (HSD3B). Progesterone 77-89 steroidogenic acute regulatory protein Homo sapiens 104-142 23200943-4 2013 First, we examined the expression of genes encoding proteins associated with progesterone biosynthesis: steroidogenic acute regulatory protein (STAR); a side chain cleavage enzyme (CYP11A1); and 3beta-hydroxysteroid dehydrogenase/ketosteroid isomerase (HSD3B). Progesterone 77-89 steroidogenic acute regulatory protein Homo sapiens 144-148 23200943-12 2013 This down-regulation of STAR, CYP11A1 and PGR in endometrial cancer may lead to decreased progesterone biosynthesis and actions although the effects on progesterone levels should be further studied. Progesterone 90-102 steroidogenic acute regulatory protein Homo sapiens 24-28 23200943-12 2013 This down-regulation of STAR, CYP11A1 and PGR in endometrial cancer may lead to decreased progesterone biosynthesis and actions although the effects on progesterone levels should be further studied. Progesterone 152-164 steroidogenic acute regulatory protein Homo sapiens 24-28 20660033-7 2010 RESULTS: Activin A alone reduced basal and FSH-induced progesterone production by decreasing the expression of StAR protein, which regulates the rate-limiting step in steroidogenesis but not P450 side-chain cleavage enzyme and 3beta-hydroxysteroid dehydrogenase. Progesterone 55-67 steroidogenic acute regulatory protein Homo sapiens 111-115 19849856-10 2009 Furthermore, we show that leptin inhibits expression of the cAMP-stimulated steroidogenic acute regulatory (StAR) protein, the rate limiting de novo protein in progesterone synthesis. Progesterone 160-172 steroidogenic acute regulatory protein Homo sapiens 108-112 20045459-3 2010 Human steroidogenic factor-1 (hSF-1) induction of the steroidogenic acute regulatory protein (StAR) gene, and the steroidogenic enzymes CYP11A1 and HSD3B2 is central to progesterone biosynthesis. Progesterone 169-181 steroidogenic acute regulatory protein Homo sapiens 54-92 20045459-3 2010 Human steroidogenic factor-1 (hSF-1) induction of the steroidogenic acute regulatory protein (StAR) gene, and the steroidogenic enzymes CYP11A1 and HSD3B2 is central to progesterone biosynthesis. Progesterone 169-181 steroidogenic acute regulatory protein Homo sapiens 94-98 18490834-16 2008 These data implied that CS has an inhibitory effect on progesterone production by regulating the expression of StAR and P450scc gene expression. Progesterone 55-67 steroidogenic acute regulatory protein Homo sapiens 111-115 15819722-10 2005 The presence of StAR, a cholesterol transporter for steroidogenesis in human epithelial ovarian carcinoma, may reflect the ability of these tumors to produce progesterone in situ that could influence biological behavior of these tumors, especially through progesterone dependent inhibition of tumor cell proliferation. Progesterone 158-170 steroidogenic acute regulatory protein Homo sapiens 16-20 15819722-10 2005 The presence of StAR, a cholesterol transporter for steroidogenesis in human epithelial ovarian carcinoma, may reflect the ability of these tumors to produce progesterone in situ that could influence biological behavior of these tumors, especially through progesterone dependent inhibition of tumor cell proliferation. Progesterone 256-268 steroidogenic acute regulatory protein Homo sapiens 16-20 15713365-9 2005 Thus, luteolytic capacity involves a critical change in responsiveness of DAX-1, StAR, and LH receptor to PGF2alpha that results in inhibition of luteal progesterone biosynthesis. Progesterone 153-165 steroidogenic acute regulatory protein Homo sapiens 81-85 12297550-0 2002 Relationship between steroidogenic acute regulatory protein expression and progesterone production in hen granulosa cells during follicle development. Progesterone 75-87 steroidogenic acute regulatory protein Homo sapiens 21-59 15269104-2 2004 It has previously been established that culturing such cells with FSH for 18-20 h induces LH-R, P450scc, and StAR expression, which enables the initiation of progesterone production. Progesterone 158-170 steroidogenic acute regulatory protein Homo sapiens 109-113 15112327-13 2004 Adding HGF suppressed the forskolin-induced steroidogenic acute regulatory protein (StAR) expression, which is a key regulator in progesterone synthesis. Progesterone 130-142 steroidogenic acute regulatory protein Homo sapiens 84-88 12485839-3 2002 As some steroids, such as progesterone, can also be synthesized de novo in the central and peripheral nervous systems and display neuroprotective and neurotrophic effects, we decided to verify the effect of cAMP on StAR gene expression in cultured Schwann cells. Progesterone 26-38 steroidogenic acute regulatory protein Homo sapiens 215-219 12297550-4 2002 Moreover, we demonstrate in granulosa cells collected from preovulatory follicles that although an acute increase in progesterone production in response to LH treatment requires rapid transcription and translation of StAR, the magnitude of progesterone production is rate-limited by one or more factors other than StAR (e.g., the P450 cholesterol side-chain enzyme). Progesterone 117-129 steroidogenic acute regulatory protein Homo sapiens 217-221 12297550-4 2002 Moreover, we demonstrate in granulosa cells collected from preovulatory follicles that although an acute increase in progesterone production in response to LH treatment requires rapid transcription and translation of StAR, the magnitude of progesterone production is rate-limited by one or more factors other than StAR (e.g., the P450 cholesterol side-chain enzyme). Progesterone 117-129 steroidogenic acute regulatory protein Homo sapiens 314-318 12297550-5 2002 Finally, the rapid turnover of StAR protein, such as occurs following the withdrawal of LH, provides an additional mechanism for the tight regulation of progesterone production that occurs during the hen ovulatory cycle, and explains the rapid loss of steroidogenesis in the postovulatory follicle. Progesterone 153-165 steroidogenic acute regulatory protein Homo sapiens 31-35 12297550-7 2002 Furthermore, subsequent to follicle selection into the preovulatory hierarchy, StAR transcription and translation is necessary but not sufficient for the full potentiation of the preovulatory surge of serum progesterone. Progesterone 207-219 steroidogenic acute regulatory protein Homo sapiens 79-83 11900886-4 2002 Changes in the level of the steroidogenic acute regulatory protein (StAR), a gene whose expression is controlled by LH most likely account for the cyclic pattern of progesterone production. Progesterone 165-177 steroidogenic acute regulatory protein Homo sapiens 28-66 11900886-4 2002 Changes in the level of the steroidogenic acute regulatory protein (StAR), a gene whose expression is controlled by LH most likely account for the cyclic pattern of progesterone production. Progesterone 165-177 steroidogenic acute regulatory protein Homo sapiens 68-72 31178965-5 2019 We found that LPS significantly inhibits progesterone production and downregulates the expressions of progesterone synthesis-associated genes (StAR, CYP11A1, and 3beta-HSD). Progesterone 102-114 steroidogenic acute regulatory protein Homo sapiens 143-147 11739437-9 2001 These results demonstrated that aberrant expression of StAR in ectopic endometriotic tissues leading to increased peritoneal progesterone is associated with the formation of endometriosis. Progesterone 125-137 steroidogenic acute regulatory protein Homo sapiens 55-59 11278318-5 2001 Inhibition of ERK activity enhanced gonadotropin-stimulated progesterone production, which was correlated with increased expression of the steroidogenic acute regulatory protein (StAR), a key regulator of progesterone synthesis. Progesterone 60-72 steroidogenic acute regulatory protein Homo sapiens 139-177 11278318-5 2001 Inhibition of ERK activity enhanced gonadotropin-stimulated progesterone production, which was correlated with increased expression of the steroidogenic acute regulatory protein (StAR), a key regulator of progesterone synthesis. Progesterone 60-72 steroidogenic acute regulatory protein Homo sapiens 179-183 11278318-5 2001 Inhibition of ERK activity enhanced gonadotropin-stimulated progesterone production, which was correlated with increased expression of the steroidogenic acute regulatory protein (StAR), a key regulator of progesterone synthesis. Progesterone 205-217 steroidogenic acute regulatory protein Homo sapiens 139-177 11278318-5 2001 Inhibition of ERK activity enhanced gonadotropin-stimulated progesterone production, which was correlated with increased expression of the steroidogenic acute regulatory protein (StAR), a key regulator of progesterone synthesis. Progesterone 205-217 steroidogenic acute regulatory protein Homo sapiens 179-183 11278318-6 2001 Therefore, it is likely that gonadotropin-stimulated progesterone formation is regulated by a pathway that includes PKA and StAR, and this process is down-regulated by ERK, due to attenuation of StAR expression. Progesterone 53-65 steroidogenic acute regulatory protein Homo sapiens 124-128 11172811-12 2001 Moreover, it seems that the cytosolic 37 kDa protein, which is responsible for the steroidogenic activity of StAR, is the primary proteasomal substrate and that the inhibition of its degradation by MG132 causes the up-regulation of progesterone production. Progesterone 232-244 steroidogenic acute regulatory protein Homo sapiens 109-113 34487832-8 2021 The mRNA and protein expression of CYP11A1 and STAR, two key enzymes in the biosynthesis of progesterone, were both suppressed. Progesterone 92-104 steroidogenic acute regulatory protein Homo sapiens 47-51 34096286-3 2021 We found that isorhamnetin promoted the secretion of estrogen and inhibited the secretion of progesterone and testosterone by modulating steroidogenesis-associated proteins and mRNA such as CYP19A1, StAR, and 3beta-HSD in ovarian GCs. Progesterone 93-105 steroidogenic acute regulatory protein Homo sapiens 199-203 35300988-4 2022 In our study, PITX2 significantly facilitated the secretion level of estrogen and progesterone through increasing CYP11A1, CYP19A1, and STAR mRNA and protein expressions in GCs. Progesterone 82-94 steroidogenic acute regulatory protein Homo sapiens 136-140 33290750-6 2020 Moreover, the expression of steroid metabolism-related genes (3betaHSD, Cyp11a1, StAR and Cyp19a1) in these two groups was down-regulated, with lower levels of estradiol (E2) and progesterone (P). Progesterone 179-191 steroidogenic acute regulatory protein Homo sapiens 81-85 33290750-6 2020 Moreover, the expression of steroid metabolism-related genes (3betaHSD, Cyp11a1, StAR and Cyp19a1) in these two groups was down-regulated, with lower levels of estradiol (E2) and progesterone (P). Progesterone 193-194 steroidogenic acute regulatory protein Homo sapiens 81-85 32497815-9 2020 The COV434 cell line microRNA-knockdown model showed that these two important microRNAs regulated the StAR-induced Cd effect on progesterone secretion. Progesterone 128-140 steroidogenic acute regulatory protein Homo sapiens 102-106 31710595-5 2020 Excessive StAR probably transported much more cholesterol into the inner membrane of the mitochondria and finally resulted in overproduction of progesterone. Progesterone 144-156 steroidogenic acute regulatory protein Homo sapiens 10-14 31619582-0 2019 Melatonin induces progesterone production in human granulosa-lutein cells through upregulation of StAR expression. Progesterone 18-30 steroidogenic acute regulatory protein Homo sapiens 98-102 31619582-1 2019 Steroidogenic acute regulatory protein (StAR) mediates the rate-limiting step in ovarian steroidogenesis and progesterone (P4) synthesis. Progesterone 109-121 steroidogenic acute regulatory protein Homo sapiens 0-38 31619582-1 2019 Steroidogenic acute regulatory protein (StAR) mediates the rate-limiting step in ovarian steroidogenesis and progesterone (P4) synthesis. Progesterone 109-121 steroidogenic acute regulatory protein Homo sapiens 40-44 31075703-9 2019 Augmentation of the progesterone biosynthetic pathway is mediated through the PPARgamma-dependent activation of EGFR and ERK1/2, leading to increased expression of STAR mRNA. Progesterone 20-32 steroidogenic acute regulatory protein Homo sapiens 164-168