PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17551930-4	2007	In RMG, membrane-impermeable progesterone conjugate induced calcium influx and subsequent phosphatidylinositol 3-kinase-mediated phosphorylation of PKC and ERK-1/2.	Progesterone	29-41	mitogen-activated protein kinase 3	Homo sapiens	156-163	
18559923-10	2008	In cultured endometrial stromal cells (ESCs), estrogen plus progesterone increased ERK1/2 phosphorylation within 15 min (P < 0.05).	Progesterone	60-72	mitogen-activated protein kinase 3	Homo sapiens	83-89	
11861509-7	2002	Our findings demonstrate that the requirement for ERK1/2 activation as a regulator of progesterone synthesis in hGL cells is stimulus dependent, and that the MEK inhibitor-sensitive step is distal to cAMP generation, but proximal to the conversion of cholesterol to pregnenolone.	Progesterone	86-98	mitogen-activated protein kinase 3	Homo sapiens	50-56	
12727988-3	2003	Moreover, the potent MAPK inhibitors, PD98059 and UO126, augment progesterone production in these cell cultures concomitantly with specific elevation of intracellular steroidogenic acute regulatory protein (StAR).	Progesterone	65-77	mitogen-activated protein kinase 3	Homo sapiens	21-25	
11861509-0	2002	Requirement for ERK1/2 activation in the regulation of progesterone production in human granulosa-lutein cells is stimulus specific.	Progesterone	55-67	mitogen-activated protein kinase 3	Homo sapiens	16-22	
9623609-9	1998	Since only capacitated spermatozoa are able to respond to progesterone, these data strongly indicate that ERKs are involved in the regulation of capacitation.	Progesterone	58-70	mitogen-activated protein kinase 3	Homo sapiens	106-110	
11735115-0	2001	Role of ERK1/2 in the differential synthesis of progesterone and estradiol by granulosa cells.	Progesterone	48-60	mitogen-activated protein kinase 3	Homo sapiens	8-14	
11735115-3	2001	Here, we provide evidence that two members of the mitogen-activated protein kinase family, extracellular signal-regulated kinase-1 and -2 (ERK1/2) can differentially regulate FSH-stimulated estradiol and progesterone production.	Progesterone	204-216	mitogen-activated protein kinase 3	Homo sapiens	139-145	
11735115-8	2001	Collectively, this study clearly identified ERK1/2 as the first intracellular signaling molecules that differentially regulate FSH-induced progesterone and estradiol synthesis in GCs.	Progesterone	139-151	mitogen-activated protein kinase 3	Homo sapiens	44-50	
31075703-9	2019	Augmentation of the progesterone biosynthetic pathway is mediated through the PPARgamma-dependent activation of EGFR and ERK1/2, leading to increased expression of STAR mRNA.	Progesterone	20-32	mitogen-activated protein kinase 3	Homo sapiens	121-127	
34478807-8	2022	These results together suggest that dual inhibition of AKT and ERK1/2 pathways suppresses the estrogen-dominant state and concomitantly increases the progesterone-responsive state of the endometrium.	Progesterone	150-162	mitogen-activated protein kinase 3	Homo sapiens	63-69	
31233701-5	2019	Addition of ERK1/2 (U0126), EGFR (AG1478) and PPARgamma (GW9662) inhibitors prevented the ROSI-induced STAR mRNA expression and progesterone production after 48h.	Progesterone	128-140	mitogen-activated protein kinase 3	Homo sapiens	12-18	
31233701-9	2019	Overall, these data suggested that PPARgamma, EGFR and ERK1/2 were involved in the stimulatory effect of ROSI on STAR expression and progesterone production in undifferentiated human cumulus granulosa cells.	Progesterone	133-145	mitogen-activated protein kinase 3	Homo sapiens	55-61	
34865992-11	2022	Alternatively, progesterone slightly decreased the phosphorylation of pro-proliferative Erk1/2 and Akt kinases and upregulated the anti-proliferative pSmad1-Id1/2 axis in IL-6-incubated PASMCs.	Progesterone	15-27	mitogen-activated protein kinase 3	Homo sapiens	88-94	
31421164-3	2019	Unlike MPA, Pg acts through VEGF, nitric oxide, PI3K and ERK1/2 signaling pathways.	Progesterone	12-14	mitogen-activated protein kinase 3	Homo sapiens	57-63	
25140399-13	2014	The inhibition of the Smad3 and ERK1/2 signaling pathways attenuated the TGF-beta1-induced downregulation of StAR expression and progesterone production.	Progesterone	129-141	mitogen-activated protein kinase 3	Homo sapiens	32-38	
28651331-0	2017	IL-1beta Upregulates StAR and Progesterone Production Through the ERK1/2- and p38-Mediated CREB Signaling Pathways in Human Granulosa-Lutein Cells.	Progesterone	30-42	mitogen-activated protein kinase 3	Homo sapiens	66-72	
28333280-27	2017	WIDER IMPLICATIONS OF THE FINDINGS: We have determined that hCG induces the PR through the Erk1/2 pathway in ESCs which may render them more sensitive to progesterone, increasing our understanding about the effects of hCG at the embryo-maternal interface.	Progesterone	154-166	mitogen-activated protein kinase 3	Homo sapiens	91-97	
26393302-8	2015	The inhibition of Smad3 or ERK1/2 signaling pathways attenuated the GDF-8-induced down-regulation of StAR and production of progesterone.	Progesterone	124-136	mitogen-activated protein kinase 3	Homo sapiens	27-33	
26708895-6	2015	Progesterone could induce prompt phosphorylation of ERK 1/2 and its promoting effects on FN synthesis was reversed by PD98059.	Progesterone	0-12	mitogen-activated protein kinase 3	Homo sapiens	52-59	
26062636-9	2015	Progesterone (1 and 100 pM for 30 min) attenuated arginine uptake and increased phosphorylated CAT-1, phosphorylated protein kinase Calpha (PKCalpha), and phosphorylated ERK1/2 protein content.	Progesterone	0-12	mitogen-activated protein kinase 3	Homo sapiens	170-176	
28651331-5	2017	Furthermore, IL-1beta activated the extracellular signal-regulated kinase (ERK)1/2 and p38 pathways and inhibition of the ERK1/2 and p38 pathways attenuated the IL-1beta-induced phosphorylation of CREB, StAR expression, and progesterone synthesis in granulosa-lutein cells.	Progesterone	224-236	mitogen-activated protein kinase 3	Homo sapiens	122-128	
27113901-8	2016	Moreover, activation of ERK1/2, but not PI3K/Akt, signaling was required for the AREG-induced up-regulation of StAR expression and progesterone production.	Progesterone	131-143	mitogen-activated protein kinase 3	Homo sapiens	24-30	
26062636-12	2015	While estradiol increases arginine transport and CAT-1 activity through modulation of constitutive signaling transduction pathways involving ERK, progesterone inhibits arginine transport and CAT-1 via both PKCalpha and ERK1/2 phosphorylation, an effect that predominates over estradiol.	Progesterone	146-158	mitogen-activated protein kinase 3	Homo sapiens	219-225	
22294087-6	2012	Progesterone was also able to induce phosphorylation of ERK1/2 in these cells.	Progesterone	0-12	mitogen-activated protein kinase 3	Homo sapiens	56-62	
23058370-9	2012	Functional withdrawal of progesterone results in increased p-ERK1/2, and is thus one pathway initiating abruption-associated PTD.	Progesterone	25-37	mitogen-activated protein kinase 3	Homo sapiens	61-67	
22775762-6	2012	These results imply that although the spermatozoa are sensitive to low concentrations of progesterone, they only activate motility and tyrosine kinase activation; higher concentrations are required to induce hyperactivation and acrosome reaction probably by activating multiple kinase pathways including the MAPK and AKT.	Progesterone	89-101	mitogen-activated protein kinase 3	Homo sapiens	308-312	
22294087-7	2012	Pretreatment of JEG-3 cells with a specific MAPK inhibitor (UO126) inhibited progesterone"s inhibitory effect on cell death.	Progesterone	77-89	mitogen-activated protein kinase 3	Homo sapiens	44-48	
21720253-3	2011	The expression levels of p-ERK1/2 and t-ERK1/2 in RL95-2 and KLE after stimulation by E2, progesterone (P), and TAM were detected by Western blotting.	Progesterone	90-102	mitogen-activated protein kinase 3	Homo sapiens	40-46	
21720253-3	2011	The expression levels of p-ERK1/2 and t-ERK1/2 in RL95-2 and KLE after stimulation by E2, progesterone (P), and TAM were detected by Western blotting.	Progesterone	90-102	mitogen-activated protein kinase 3	Homo sapiens	27-33	
21448845-13	2011	Both MAPK-Erk1/2 and MAPK-p38 participate in IGF-I-induced signaling pathways for progesterone production, while insulin-induced progesterone production requires MAPK-p38, but not MAPK-Erk1/2.	Progesterone	82-94	mitogen-activated protein kinase 3	Homo sapiens	10-16	
18710710-11	2009	Progesterone stimulated phosphorylation of eNOS within 30 minutes, and this effect was completely blocked by an inhibitor of PI3/Akt pathway, wortmannin, and by the extracellular signal-regulated kinase 1,2 pathway blocker UO126.	Progesterone	0-12	mitogen-activated protein kinase 3	Homo sapiens	165-204	
19849856-14	2009	In summary, leptin acts through the MAPK pathway to downregulate cAMP-induced StAR protein expression and progesterone production in immortalized human granulosa cells.	Progesterone	106-118	mitogen-activated protein kinase 3	Homo sapiens	36-40	
21761355-5	2010	Instead, we demonstrate that by selectively antagonizing ERK1/2 signaling in breast cancer cells, 2ME limits the transactivation potential of ligand-bound PR and inhibits the expression of endogenous progesterone targets, such as TF and signal transducer and activator of transcription 5.	Progesterone	200-212	mitogen-activated protein kinase 3	Homo sapiens	57-63	
20407880-7	2010	The level of ERK1/2 phosphorylation was increased by a lower progesterone concentration, but reduced by a higher concentration (1 x 10(-6) mol/L).	Progesterone	61-73	mitogen-activated protein kinase 3	Homo sapiens	13-19