PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21868758-7 2011 We further show that CRPC cells expressing a progesterone responsive T877A mutant AR are not CYP17A1 dependent, but that AR activity in these cells is still steroid dependent and mediated by upstream CYP11A1-dependent intraturmoral pregnenolone/progesterone synthesis. Progesterone 45-57 androgen receptor Homo sapiens 82-84 15316697-8 2004 We also demonstrated that a synthetic estrogen diethylstilbestrol and progesterone-related drugs such as chlormadinone acetate and allylestrenol dose-dependently inhibited the activity of AR in DU-145 and PC-3 cells. Progesterone 70-82 androgen receptor Homo sapiens 188-190 20007693-11 2010 Our results indicate that the specific amino acid residue at position 701, its interaction with the backbone of Ser(778), and the steroidal 17alpha-hydroxyl group of the ligand are all important for the distinct transcriptional responses to progesterone and cortisol of AR mutants, including the prostate cancer mutant L701H. Progesterone 241-253 androgen receptor Homo sapiens 270-272 17602304-8 2008 The androgen receptor mutations AR(877) and AR(715) displayed a 37.5- and 5.2-fold increase in transactivation activity by progesterone and a 12.6- and 5.4-fold increase by estrogen compared to the AR(WT), respectively. Progesterone 123-135 androgen receptor Homo sapiens 4-21 17602621-11 2007 17beta-Estradiol and progesterone were found to be specific activators only for the genomic signaling pathway of AR. Progesterone 21-33 androgen receptor Homo sapiens 113-115 17223690-2 2007 Interaction of wild-type AR LBD with the random phage display peptide D11FxxLF was observed with dihydrotestosterone (DHT), testosterone, R1881, estradiol, spironolactone, progesterone, and cortisol resulting in distinct dose dependency (EC50) values for each ligand and correlating well with the reported rank order potency of these agonists. Progesterone 172-184 androgen receptor Homo sapiens 25-27 15161534-8 2004 RESULTS: Growth of LNCaPas-AR was inhibited significantly (P < 0.05) compared with that of LNCaP and LNCaPNeo at 1 nmol/L R1881, 10 nmol/L 17beta-estradiol, and 1 nmol/L progesterone, respectively. Progesterone 173-185 androgen receptor Homo sapiens 27-29 15161534-2 2004 Prostate cancer cell line LNCaP contains AR that can be activated by androgen, estrogen and progesterone. Progesterone 92-104 androgen receptor Homo sapiens 41-43 14667996-0 2003 A role for the androgen receptor in the endometrial antiproliferative effects of progesterone antagonists. Progesterone 81-93 androgen receptor Homo sapiens 15-32 14667996-4 2003 Recent studies of ours in both women and macaques revealed that the endometrial androgen receptor (AR) was increased by progesterone antagonist treatment. Progesterone 120-132 androgen receptor Homo sapiens 80-97 14667996-4 2003 Recent studies of ours in both women and macaques revealed that the endometrial androgen receptor (AR) was increased by progesterone antagonist treatment. Progesterone 120-132 androgen receptor Homo sapiens 99-101 14667996-5 2003 Because androgens are known to suppress estrogen-dependent endometrial proliferation, we hypothesized that the AR was involved in the antiproliferative effects induced by progesterone antagonists. Progesterone 171-183 androgen receptor Homo sapiens 111-113 14667996-9 2003 These data implicate the AR as a functional component of the mechanism through which progesterone antagonists induce endometrial antiproliferative effects in the presence of estrogens. Progesterone 85-97 androgen receptor Homo sapiens 25-27 12941814-12 2003 In addition, activation of a common tumor-derived AR allele by 17 beta-estradiol and progesterone was inhibited through ectopic expression of cyclin D1. Progesterone 85-97 androgen receptor Homo sapiens 50-52 11673900-6 2001 As expected, AR-mediated responses were also elicited by high concentrations of the steroids progesterone, 17beta-estradiol, d-aldosterone, and dexamethasone, with observed EC50 values 10 to 350,000 times higher than that for R1881. Progesterone 93-105 androgen receptor Homo sapiens 13-15 11935209-8 2002 Another steroid hormone that interacts with the androgen receptor in LNCaP cells (progesterone) also promoted apoptosis of these cells. Progesterone 82-94 androgen receptor Homo sapiens 48-65 12449343-5 2002 Indeed, because of the alterations detected in the AR gene, many noncognate activators, including estrogen, progesterone, peptide growth factors, and cytokines, are able to induce transactivation of the AR under androgen-depleted conditions. Progesterone 108-120 androgen receptor Homo sapiens 51-53 12449343-5 2002 Indeed, because of the alterations detected in the AR gene, many noncognate activators, including estrogen, progesterone, peptide growth factors, and cytokines, are able to induce transactivation of the AR under androgen-depleted conditions. Progesterone 108-120 androgen receptor Homo sapiens 203-205 12361945-2 2002 The AR is part of a large family of steroid receptors that also includes the glucocorticoid, progesterone, and mineralocorticoid receptors. Progesterone 93-105 androgen receptor Homo sapiens 4-6 11397870-8 2001 E(2) + RU 486 or E(2) + P + RU 486 treatment produced a striking up-regulation of glandular epithelial AR staining and enhanced the stromal AR signal. Progesterone 24-25 androgen receptor Homo sapiens 103-105 11397870-8 2001 E(2) + RU 486 or E(2) + P + RU 486 treatment produced a striking up-regulation of glandular epithelial AR staining and enhanced the stromal AR signal. Progesterone 24-25 androgen receptor Homo sapiens 140-142 11320241-4 2001 This structural difference in the binding pocket can explain the ability of the mutant AR found in LNCaP cells (T877A) to accommodate progesterone and other ligands that the wild-type receptor cannot. Progesterone 134-146 androgen receptor Homo sapiens 87-89 8828509-4 1996 In agreement with the aberrant ligand specificity of the mutated androgen receptor in LNCaP cells, stimulation of lipid accumulation was also apparent after treatment with progesterone and estradiol. Progesterone 172-184 androgen receptor Homo sapiens 65-82 9079641-2 1997 A consensus glucocorticoid response element (GRE) can mediate transactivation by AR and other members of the AR/glucocorticoid (GR)/progesterone (PR)/mineralocorticoid (MR) receptor subfamily. Progesterone 132-144 androgen receptor Homo sapiens 81-83 21597729-4 1995 Despite the finding that the androgen receptor of LNCaP aberrantly recognizes a variety of steroids, including estrogen and progesterone, as androgenic agonists, there are no studies which examine the effect of estrogen antagonists and progesterone antagonist on baseline and androgen-stimulated LNCaP growth. Progesterone 124-136 androgen receptor Homo sapiens 29-46 8845582-5 1995 AR, along with receptors for a number of C-21 steroids such as glucocorticoid, mineralocorticoid, and progesterone, share the same 15 base pair consensus element composed of 5"-GGA/TACAnnnTGTTCT-3". Progesterone 102-114 androgen receptor Homo sapiens 0-2 35492874-3 2022 High doses of progesterone activate canonical and non-canonical androgen receptor (AR) target genes. Progesterone 14-26 androgen receptor Homo sapiens 64-81 8145761-0 1993 Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone. Progesterone 113-125 androgen receptor Homo sapiens 7-24 35492874-3 2022 High doses of progesterone activate canonical and non-canonical androgen receptor (AR) target genes. Progesterone 14-26 androgen receptor Homo sapiens 83-85 35201849-0 2022 A Case of Prostate Cancer Harboring Androgen Receptor T878A Progesterone-Responsive Mutant Emerging After Abiraterone Acetate Treatment Responding to Darolutamide. Progesterone 60-72 androgen receptor Homo sapiens 36-53 28711501-4 2017 We show that the progestins bind to the androgen receptor (AR) with similar affinities to each other and progesterone, while none bind estrogen receptor (ER)-beta, and only norethisterone acetate, levonorgestrel and gestodene bind ERalpha. Progesterone 105-117 androgen receptor Homo sapiens 40-57 2422638-7 1986 [3H]Mibolerone binding to the androgen receptor was competed effectively with unlabeled dihydrotestosterone, R1881, and mibolerone but not by progesterone, diethylstilbestrol or R5020, in the presence of triamcinolone acetonide. Progesterone 142-154 androgen receptor Homo sapiens 30-47 2728128-3 1989 The androgen receptor shows considerable cross binding activity with progesterone and estradiol but not with the glucocorticoid triamcinolone acetonide. Progesterone 69-81 androgen receptor Homo sapiens 4-21 3263955-8 1988 The affinity of steroids for the androgen receptor decreased in the order of: R1881 (relative binding affinity: 100.0) greater than dihydrotestosterone (67.7) greater than progesterone (29.4) greater than testosterone (23.8) greater than estradiol (4.3) greater than triamcinolone acetonide (less than 0.1). Progesterone 172-184 androgen receptor Homo sapiens 33-50 28711501-4 2017 We show that the progestins bind to the androgen receptor (AR) with similar affinities to each other and progesterone, while none bind estrogen receptor (ER)-beta, and only norethisterone acetate, levonorgestrel and gestodene bind ERalpha. Progesterone 105-117 androgen receptor Homo sapiens 59-61 28277313-3 2017 The aim of our study is to assess the role of AR expression in ECs and correlate its expression with estrogen (ER) and progesterone (PR). Progesterone 119-131 androgen receptor Homo sapiens 46-48 31966643-7 2017 Positive expression of AR was significantly correlated with smaller tumor size, early T stage, fewer lymph node metastases, early AJCC stage, lower histologic grade, estrogen receptor/progesterone receptor positivity, more luminal A type, less TNBC, longer disease-free survival and overall survival, fewer distant metastasis and no deaths from breast cancer (all P < 0.05). Progesterone 184-196 androgen receptor Homo sapiens 23-25