PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32244545-10 2020 Furthermore, progesterone-calcitriol potentiated the anti-growth effects of DDP on cancer cells by attenuating the expression of SMAD2/3, multidrug resistance protein- 1 (MDR-1), and ABC transporters (ABCG1, and ABCG2), thereby impeding the efflux of chemo drugs from cancer cells. Progesterone 13-25 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 212-217 23988382-2 2013 Previous studies have shown that steroid hormones, like progesterone (PROG), regulate BCRP expression. Progesterone 56-68 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 86-90 18692485-2 2008 We show here for the first time that dexamethasone (DEX) and progesterone (PROG) are able to strongly inhibit ABCG2 expression in progesterone receptor (PR)-positive MCF7 and PR-negative MDA-MB-231 breast cells. Progesterone 61-73 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 110-115 22348324-0 2012 Progesterone receptor downregulates breast cancer resistance protein expression via binding to the progesterone response element in breast cancer. Progesterone 99-111 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 36-68 22348324-8 2012 While at a cellular level, after being treated by progesterone and 17beta-estradiol, BCRP mRNA and protein levels were significantly reduced in a concentration-dependent manner in MCF-7/P-BCRP cells with PR bound to the identified PRE in BCRP promoter. Progesterone 50-62 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 85-89 22348324-8 2012 While at a cellular level, after being treated by progesterone and 17beta-estradiol, BCRP mRNA and protein levels were significantly reduced in a concentration-dependent manner in MCF-7/P-BCRP cells with PR bound to the identified PRE in BCRP promoter. Progesterone 50-62 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 188-192 22348324-8 2012 While at a cellular level, after being treated by progesterone and 17beta-estradiol, BCRP mRNA and protein levels were significantly reduced in a concentration-dependent manner in MCF-7/P-BCRP cells with PR bound to the identified PRE in BCRP promoter. Progesterone 50-62 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 188-192 22581381-10 2012 Estradiol, testosterone, progesterone and androstenedione inhibited BCRP-mediated uptake of (3)H-estrone sulphate (E(1)S) most potently, with calculated inhibitory constant (Ki) values of 5.0 +- 0.2, 36 +- 14, 14.7 +- 1.3 and 217 +- 13 muM, respectively. Progesterone 25-37 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 68-72 18692485-2 2008 We show here for the first time that dexamethasone (DEX) and progesterone (PROG) are able to strongly inhibit ABCG2 expression in progesterone receptor (PR)-positive MCF7 and PR-negative MDA-MB-231 breast cells. Progesterone 75-79 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 110-115 18086804-6 2008 This issue of Molecular Pharmacology includes a study (p. 845) now conclusively demonstrating that progesterone acts via the progesterone A and B receptors to regulate BCRP expression in a placental cell line. Progesterone 99-111 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 168-172 18042733-2 2008 Previous studies have shown that steroid hormones such as 17beta-estradiol and progesterone can affect BCRP expression in cancer cells. Progesterone 79-91 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 103-107 18042733-3 2008 In this study, we investigated the molecular mechanism by which BCRP expression in human placental choriocarcinoma BeWo cells is regulated by progesterone. Progesterone 142-154 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 64-68 18042733-7 2008 Consistently, transcriptional activity of the BCRP promoter was induced 2- to 6-fold by 10(-8) to 10(-5) M progesterone in PRB-transfected cells. Progesterone 107-119 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 46-50 18042733-9 2008 Mutations in a novel progesterone response element (PRE) identified between -243 to -115 bp of the BCRP promoter region significantly attenuated the progesterone-response in PRB-transfected cells, and deletion of the PRE nearly completely abrogated the progesterone effect. Progesterone 21-33 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 99-103 18042733-9 2008 Mutations in a novel progesterone response element (PRE) identified between -243 to -115 bp of the BCRP promoter region significantly attenuated the progesterone-response in PRB-transfected cells, and deletion of the PRE nearly completely abrogated the progesterone effect. Progesterone 149-161 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 99-103 18042733-9 2008 Mutations in a novel progesterone response element (PRE) identified between -243 to -115 bp of the BCRP promoter region significantly attenuated the progesterone-response in PRB-transfected cells, and deletion of the PRE nearly completely abrogated the progesterone effect. Progesterone 149-161 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 99-103 17524480-4 2007 We hypothesised that there are changes in placental Bcrp1 (the mouse orthologue of human BCRP) expression during pregnancy and that these correlate with changes in progesterone production that occur in late gestation. Progesterone 164-176 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 89-93 18042733-11 2008 Collectively, progesterone induces BCRP expression in BeWo cells via PRB but not PRA. Progesterone 14-26 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 35-39 16849015-8 2006 In addition, progesterone suppressed the induction of ABCG2 expression by 17-beta-estradiol at 1-10 microM. Progesterone 13-25 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 54-59 16849015-9 2006 CONCLUSION: The expression of ABCG2 in the placenta is regulated by estrogen and progesterone during gestation. Progesterone 81-93 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 30-35 12668685-6 2003 Interestingly, the BCRP-associated ATPase activity in L. lactis was significantly stimulated by (i) sterols including cholesterol and estradiol, (ii) natural steroids such as progesterone and testosterone, and (iii) the anti-estrogen anticancer drug tamoxifen. Progesterone 175-187 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 19-23 16352672-0 2006 Regulation of BCRP/ABCG2 expression by progesterone and 17beta-estradiol in human placental BeWo cells. Progesterone 39-51 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 14-18 16352672-0 2006 Regulation of BCRP/ABCG2 expression by progesterone and 17beta-estradiol in human placental BeWo cells. Progesterone 39-51 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 19-24 16352672-3 2006 Hence, we examined the effects of progesterone (P4) and 17beta-estradiol (E2) on BCRP expression in the human placental BeWo cells. Progesterone 34-46 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 81-85 16244436-6 2005 Expression levels of the ABCG2 gene and protein in BeWo cells were decreased by progesterone treatment. Progesterone 80-92 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 25-30