PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17981605-6 2008 Among the most promising agents for the modulation of the Th1/Th2 balance are progestogens such as progesterone and dydrogesterone. Progesterone 99-111 negative elongation factor complex member C/D Homo sapiens 58-61 23422356-4 2013 Our results indicate that, in early gestation, IL-4 and -10 serum concentrations are elevated and might depend on progesterone that could act as a potent inhibitor of Th1 responses inducing, conversely, the production of Th2-type cytokines (i.e., IL-10 and IL-4). Progesterone 114-126 negative elongation factor complex member C/D Homo sapiens 167-170 18788472-6 2008 Among the promising agents for the modulation of the Th1/Th2 balance are progestogens like progesterone and dydrogesterone; this review also discusses recent evidence that progestogens are capable of modulating cytokine production patterns in pregnancy loss. Progesterone 91-103 negative elongation factor complex member C/D Homo sapiens 53-56 16704920-1 2006 One of the most important immunological modifications during pregnancy is the Th1/Th2 shift, due to the progressive increase of progesterone and estrogens during pregnancy, which reach their peak-level in the third trimester of gestation. Progesterone 128-140 negative elongation factor complex member C/D Homo sapiens 78-81 17356463-5 2007 The estrogen- and progesterone-mediated inhibition of Th1/inflammatory cytokines was greater in HIV-infected subjects (35% decrease for both hormones) compared with uninfected subjects (12% and 19% for estrogen and progesterone, respectively), whereas the effect on proliferation and PBMC phenotype did not differ by HIV status. Progesterone 18-30 negative elongation factor complex member C/D Homo sapiens 54-57 16188436-4 2005 When peripheral mononuclear cells from recurrent aborters are incubated with progesterone or dydrogesterone in vitro, T-helper (Th)2 cytokines such as interleukin (IL)-4 and IL-6 markedly increase whereas the Th1 cytokine interferon-gamma decreases. Progesterone 77-89 negative elongation factor complex member C/D Homo sapiens 209-212 8839782-6 1996 Interestingly, we also found that, at least in vitro, progesterone promotes the preferential development of Th2-like cells and induces transient IL-4 production by established Th1 cells, whereas relaxin, another corpus luteum-derived hormone, mainly promotes the development of Th1-like cells. Progesterone 54-66 negative elongation factor complex member C/D Homo sapiens 176-179 15760381-8 2005 CONCLUSIONS: Pg increases the numbers of monocytic DCs locally and it may be speculated that these cells help the Th1/Th2 switching in pregnancy. Progesterone 13-15 negative elongation factor complex member C/D Homo sapiens 114-117 12042296-0 2002 Th1 and Th2 cytokine profiles in recurrent aborters may merely reflect the progesterone status. Progesterone 75-87 negative elongation factor complex member C/D Homo sapiens 0-3 11801642-8 2002 The p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 inhibited Th1 development and enhanced Th2 development, as did progesterone, indicating that p38 MAPK and extracellular signal-regulated kinase pathways are involved in Th1 development. Progesterone 130-142 negative elongation factor complex member C/D Homo sapiens 236-239 10928418-0 2000 Progesterone inhibits in-vitro embryotoxic Th1 cytokine production to trophoblast in women with recurrent pregnancy loss. Progesterone 0-12 negative elongation factor complex member C/D Homo sapiens 43-46 10928418-7 2000 Our data suggest that assaying Th1 cytokines in supernatants of peripheral blood mononuclear cells cultured with a protein extract from trophoblast may identify individuals more likely to benefit from potentially immunosuppressive doses of progesterone. Progesterone 240-252 negative elongation factor complex member C/D Homo sapiens 31-34 14551795-4 2004 There were negative correlations between the Th1:Th2 ratio and serum hCG levels (mIU/ml) (Th1:Th2 ratio = 14.5-4.52 x 10(-5)xhCG, r(2)=0.41, p<0.05) and between the Th1:Th2 ratio and serum progesterone levels (ng/dl; Th1:Th2 ratio = 23.0-0.63 x progesterone, r(2)=0.36, p<0.05). Progesterone 192-204 negative elongation factor complex member C/D Homo sapiens 45-48 14551795-4 2004 There were negative correlations between the Th1:Th2 ratio and serum hCG levels (mIU/ml) (Th1:Th2 ratio = 14.5-4.52 x 10(-5)xhCG, r(2)=0.41, p<0.05) and between the Th1:Th2 ratio and serum progesterone levels (ng/dl; Th1:Th2 ratio = 23.0-0.63 x progesterone, r(2)=0.36, p<0.05). Progesterone 248-260 negative elongation factor complex member C/D Homo sapiens 45-48 11801642-6 2002 Because IL-10 is known to inhibit APC production of IL-12, Th1 development may be also suppressed indirectly by progesterone. Progesterone 112-124 negative elongation factor complex member C/D Homo sapiens 59-62 8839782-6 1996 Interestingly, we also found that, at least in vitro, progesterone promotes the preferential development of Th2-like cells and induces transient IL-4 production by established Th1 cells, whereas relaxin, another corpus luteum-derived hormone, mainly promotes the development of Th1-like cells. Progesterone 54-66 negative elongation factor complex member C/D Homo sapiens 278-281 35185927-0 2022 Progesterone Inhibits the Establishment of Activation-Associated Chromatin During TH1 Differentiation. Progesterone 0-12 negative elongation factor complex member C/D Homo sapiens 82-85 35185927-1 2022 TH1-mediated diseases such as multiple sclerosis (MS) and rheumatoid arthritis (RA) improve during pregnancy, coinciding with increasing levels of the pregnancy hormone progesterone (P4), highlighting P4 as a potential mediator of this immunomodulation. Progesterone 169-181 negative elongation factor complex member C/D Homo sapiens 0-3 31547021-7 2019 Estrogen and progesterone enhance the activities of Th2/regulatory T cell (Treg) but suppress Th1/Th17. Progesterone 13-25 negative elongation factor complex member C/D Homo sapiens 94-97