PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2549949-0 1989 Scrape-loaded p21ras down-regulates agonist-stimulated inositol phosphate production by a mechanism involving protein kinase C. The effect of scrape-loaded [Val-12]p21ras on agonist-stimulated phosphatidylinositol 4,5-bisphosphate (PIP2) turnover in Swiss-3T3 cells was studied. val-12 157-163 Harvey rat sarcoma virus oncogene Mus musculus 14-20 8359224-9 1993 This concentration of TPEN totally blocked DNA synthesis both in control and c-Ha-ras(val-12)-expressing fibroblasts. val-12 86-92 Harvey rat sarcoma virus oncogene Mus musculus 77-85 8359224-12 1993 The results suggest that c-Ha-ras(val-12)-induced proliferation is independent of changes in [Ca2+]i. val-12 34-40 Harvey rat sarcoma virus oncogene Mus musculus 25-33 2549949-0 1989 Scrape-loaded p21ras down-regulates agonist-stimulated inositol phosphate production by a mechanism involving protein kinase C. The effect of scrape-loaded [Val-12]p21ras on agonist-stimulated phosphatidylinositol 4,5-bisphosphate (PIP2) turnover in Swiss-3T3 cells was studied. val-12 157-163 Harvey rat sarcoma virus oncogene Mus musculus 164-170 10896935-6 2000 Treatment with LY294002, an inhibitor for phosphoinositide 3-OH kinase (PI3K), significantly inhibits Ha-Ras(Val-12)-induced CD44 cleavage, whereas that with PD98059, an inhibitor for MEK, does not. val-12 109-115 Harvey rat sarcoma virus oncogene Mus musculus 102-108 10896935-4 2000 Here, we demonstrate that the expression of the dominant active mutant of Ha-Ras (Ha-Ras(Val-12)) induces redistribution of CD44 to the newly generated membrane ruffling area and CD44 ectodomain cleavage. val-12 89-95 Harvey rat sarcoma virus oncogene Mus musculus 74-80 10896935-4 2000 Here, we demonstrate that the expression of the dominant active mutant of Ha-Ras (Ha-Ras(Val-12)) induces redistribution of CD44 to the newly generated membrane ruffling area and CD44 ectodomain cleavage. val-12 89-95 Harvey rat sarcoma virus oncogene Mus musculus 82-88 10896935-5 2000 The migration assay revealed that the CD44 cleavage contributes to the Ha-Ras(Val-12)-induced migration of NIH3T3 cells on hyaluronate substrate. val-12 78-84 Harvey rat sarcoma virus oncogene Mus musculus 71-77 10896935-8 2000 Moreover, the expression of dominant negative mutants of Cdc42 and Rac1 inhibits the Ha-Ras(Val-12)-induced CD44 cleavage. val-12 92-98 Harvey rat sarcoma virus oncogene Mus musculus 85-91