PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17234720-9 2007 Taken together, the present study demonstrates that xanthorrhizol not only delays or inhibits tumor formation, but also reverses the carcinogenic process at pre-malignant stages by reducing the protein levels of ODC, iNOS and COX-2 regulated by the NF-kappaB, mitogen-activated protein kinases and/or Akt. xanthorrhizol 52-65 thymoma viral proto-oncogene 1 Mus musculus 301-304 33683188-0 2021 Xanthorrhizol Suppresses Vascular Endothelial Growth Factor-Induced Angiogenesis by Modulating Akt/eNOS Signaling and the NF-[Formula: see text]B-Dependent Expression of Cell Adhesion Molecules. xanthorrhizol 0-13 thymoma viral proto-oncogene 1 Mus musculus 95-98 33683188-5 2021 Xanthorrhizol inhibited the phosphorylation of Akt and endothelial nitric oxide synthase (eNOS) and the expression of vascular cell adhesion molecule (VCAM)-1 and E-selectin in VEGF-treated HUVECs. xanthorrhizol 0-13 thymoma viral proto-oncogene 1 Mus musculus 47-50 33683188-10 2021 Taken together, xanthorrhizol inhibits VEGF-induced angiogenesis of endothelial cells by blocking the activation of the PI3K/Akt/eNOS axis and subsequent upregulation of adhesion molecules induced by the transcriptional activation of NF-[Formula: see text]B. xanthorrhizol 16-29 thymoma viral proto-oncogene 1 Mus musculus 125-128 17234720-8 2007 Furthermore, western blot analysis showed that xanthorrhizol suppressed the activation of extracellular signal-regulated protein kinase, p38, c-Jun-N-terminal kinase and Akt in mice after topical application for 6 weeks following the induction of papillomas. xanthorrhizol 47-60 thymoma viral proto-oncogene 1 Mus musculus 170-173