PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35415222-14	2022	Discussion: PAPSS2 assists with the sulfonation of dehydroepiandrosterone (DHEA) to DHEA sulfate and the sulfonation of proteoglycans in the cartilage, necessary for endochondral bone formation.	Dehydroepiandrosterone	51-73	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	12-18	
35415222-14	2022	Discussion: PAPSS2 assists with the sulfonation of dehydroepiandrosterone (DHEA) to DHEA sulfate and the sulfonation of proteoglycans in the cartilage, necessary for endochondral bone formation.	Dehydroepiandrosterone	75-79	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	12-18	
35415222-15	2022	PAPSS2-inactivating variants present with skeletal dysplasia and elevated DHEA levels.	Dehydroepiandrosterone	74-78	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	0-6	
29743239-0	2018	Human DHEA sulfation requires direct interaction between PAPS synthase 2 and DHEA sulfotransferase SULT2A1.	Dehydroepiandrosterone	6-10	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	57-72	
29743239-4	2018	In knockdown studies in human adrenocortical NCI-H295R1 cells, we found that PAPSS2, but not PAPSS1, is required for efficient DHEA sulfation.	Dehydroepiandrosterone	127-131	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	77-83	
29743239-6	2018	Co-expression of cytoplasmic SULT2A1 with a cytoplasmic PAPSS2 variant supported DHEA sulfation more efficiently than co-expression with nuclear PAPSS2 or nuclear/cytosolic PAPSS1.	Dehydroepiandrosterone	81-85	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	56-62	
29743239-10	2018	These findings elucidate the mechanistic basis for the selective requirement for PAPSS2 in human DHEA sulfation.	Dehydroepiandrosterone	97-101	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	81-87	
25594860-0	2015	PAPSS2 deficiency causes androgen excess via impaired DHEA sulfation--in vitro and in vivo studies in a family harboring two novel PAPSS2 mutations.	Dehydroepiandrosterone	54-58	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	0-6	
25594860-1	2015	CONTEXT: PAPSS2 (PAPS synthase 2) provides the universal sulfate donor PAPS (3"-phospho-adenosine-5"-phosphosulfate) to all human sulfotransferases, including SULT2A1, responsible for sulfation of the crucial androgen precursor dehydroepiandrosterone (DHEA).	Dehydroepiandrosterone	228-250	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	9-15	
25594860-1	2015	CONTEXT: PAPSS2 (PAPS synthase 2) provides the universal sulfate donor PAPS (3"-phospho-adenosine-5"-phosphosulfate) to all human sulfotransferases, including SULT2A1, responsible for sulfation of the crucial androgen precursor dehydroepiandrosterone (DHEA).	Dehydroepiandrosterone	228-250	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	17-32	
25594860-1	2015	CONTEXT: PAPSS2 (PAPS synthase 2) provides the universal sulfate donor PAPS (3"-phospho-adenosine-5"-phosphosulfate) to all human sulfotransferases, including SULT2A1, responsible for sulfation of the crucial androgen precursor dehydroepiandrosterone (DHEA).	Dehydroepiandrosterone	252-256	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	9-15	
25594860-1	2015	CONTEXT: PAPSS2 (PAPS synthase 2) provides the universal sulfate donor PAPS (3"-phospho-adenosine-5"-phosphosulfate) to all human sulfotransferases, including SULT2A1, responsible for sulfation of the crucial androgen precursor dehydroepiandrosterone (DHEA).	Dehydroepiandrosterone	252-256	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	17-32	
25594860-2	2015	Impaired DHEA sulfation is thought to increase the conversion of DHEA toward active androgens, a proposition supported by the previous report of a girl with inactivating PAPSS2 mutations who presented with low serum DHEA sulfate and androgen excess, clinically manifesting with premature pubarche and early-onset polycystic ovary syndrome.	Dehydroepiandrosterone	9-13	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	170-176	
25594860-2	2015	Impaired DHEA sulfation is thought to increase the conversion of DHEA toward active androgens, a proposition supported by the previous report of a girl with inactivating PAPSS2 mutations who presented with low serum DHEA sulfate and androgen excess, clinically manifesting with premature pubarche and early-onset polycystic ovary syndrome.	Dehydroepiandrosterone	65-69	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	170-176	
25594860-9	2015	CONCLUSIONS: We provide direct in vivo evidence for the significant functional impact of mutant PAPSS2 on DHEA sulfation and androgen activation.	Dehydroepiandrosterone	106-110	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	96-102