PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9161664-3 1997 DHEA appears to possess immunomodulating effects, perhaps by enhancing the secretion of IL-2 from activated T cells as demonstrated in a murine model. Dehydroepiandrosterone 0-4 interleukin 2 Mus musculus 88-92 16426146-5 2006 DHEA also significantly reduced the mitogen-induced production of the proinflammatory cytokine interleukin-1 (IL-1) as well as the Th1 cytokines IL-2 and interferon-gamma (IFN-gamma). Dehydroepiandrosterone 0-4 interleukin 2 Mus musculus 145-149 9572155-7 1998 DHEA, MLT, and DHEA + MLT help to regulate immune function in aged female C57BL/6 mice by significantly (P < 0.05) increasing Th1 cytokines, IL-2, and IFN-gamma or significantly (P < 0.05) decreasing Th2 cytokines, IL-6, and IL-10, thus regulating cytokine production. Dehydroepiandrosterone 0-4 interleukin 2 Mus musculus 144-148 9572155-7 1998 DHEA, MLT, and DHEA + MLT help to regulate immune function in aged female C57BL/6 mice by significantly (P < 0.05) increasing Th1 cytokines, IL-2, and IFN-gamma or significantly (P < 0.05) decreasing Th2 cytokines, IL-6, and IL-10, thus regulating cytokine production. Dehydroepiandrosterone 15-19 interleukin 2 Mus musculus 144-148 9626336-0 1998 Adrenal hormone modulation of type 1 and type 2 cytokine production by spleen cells: dexamethasone and dehydroepiandrosterone suppress interleukin-2, interleukin-4, and interferon-gamma production in vitro. Dehydroepiandrosterone 103-125 interleukin 2 Mus musculus 135-148 9402143-4 1997 The uninfected mice supplemented with 0.06% DHEA showed a significant (P < 0.05) increase in interleukin-2 (IL-2) and gamma-interferon (IFN-gamma) production, and hepatic vitamin E levels. Dehydroepiandrosterone 44-48 interleukin 2 Mus musculus 96-109 9402143-4 1997 The uninfected mice supplemented with 0.06% DHEA showed a significant (P < 0.05) increase in interleukin-2 (IL-2) and gamma-interferon (IFN-gamma) production, and hepatic vitamin E levels. Dehydroepiandrosterone 44-48 interleukin 2 Mus musculus 111-115 9402143-6 1997 DHEA supplementation prevented the retrovirus-induced loss of cytokines (IL-2 and IFN-gamma) secretion by mitogen stimulated spleen cells. Dehydroepiandrosterone 0-4 interleukin 2 Mus musculus 73-77 9248620-1 1997 Previous studies in mice have shown that dehydroepiandrosterone (DHEA) increases the production of Th1-associated lymphokines, and of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), by lymphocytes. Dehydroepiandrosterone 41-63 interleukin 2 Mus musculus 134-147 9248620-1 1997 Previous studies in mice have shown that dehydroepiandrosterone (DHEA) increases the production of Th1-associated lymphokines, and of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), by lymphocytes. Dehydroepiandrosterone 41-63 interleukin 2 Mus musculus 149-153 9248620-1 1997 Previous studies in mice have shown that dehydroepiandrosterone (DHEA) increases the production of Th1-associated lymphokines, and of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), by lymphocytes. Dehydroepiandrosterone 65-69 interleukin 2 Mus musculus 134-147 9248620-1 1997 Previous studies in mice have shown that dehydroepiandrosterone (DHEA) increases the production of Th1-associated lymphokines, and of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), by lymphocytes. Dehydroepiandrosterone 65-69 interleukin 2 Mus musculus 149-153 10346984-5 1999 DHEA administration restored the normally depressed splenocyte proliferation as well as interleukin 2, interleukin 3, and interferon gamma elaboration following trauma and haemorrhage. Dehydroepiandrosterone 0-4 interleukin 2 Mus musculus 88-101 8952743-3 1996 Recent studies of our own as well as others have shown that dehydroepiandrosterone (DHEA), an intermediate compound in testosterone synthesis, significantly up-regulates IL-2 production of normal T cells and that administration of exogenous DHEA or IL-2 via a vaccinia construct to mice with murine lupus dramatically reverses their clinical autoimmune diseases. Dehydroepiandrosterone 60-82 interleukin 2 Mus musculus 170-174 8952743-3 1996 Recent studies of our own as well as others have shown that dehydroepiandrosterone (DHEA), an intermediate compound in testosterone synthesis, significantly up-regulates IL-2 production of normal T cells and that administration of exogenous DHEA or IL-2 via a vaccinia construct to mice with murine lupus dramatically reverses their clinical autoimmune diseases. Dehydroepiandrosterone 60-82 interleukin 2 Mus musculus 249-253 8952743-3 1996 Recent studies of our own as well as others have shown that dehydroepiandrosterone (DHEA), an intermediate compound in testosterone synthesis, significantly up-regulates IL-2 production of normal T cells and that administration of exogenous DHEA or IL-2 via a vaccinia construct to mice with murine lupus dramatically reverses their clinical autoimmune diseases. Dehydroepiandrosterone 84-88 interleukin 2 Mus musculus 170-174 8952743-3 1996 Recent studies of our own as well as others have shown that dehydroepiandrosterone (DHEA), an intermediate compound in testosterone synthesis, significantly up-regulates IL-2 production of normal T cells and that administration of exogenous DHEA or IL-2 via a vaccinia construct to mice with murine lupus dramatically reverses their clinical autoimmune diseases. Dehydroepiandrosterone 84-88 interleukin 2 Mus musculus 249-253 8952743-3 1996 Recent studies of our own as well as others have shown that dehydroepiandrosterone (DHEA), an intermediate compound in testosterone synthesis, significantly up-regulates IL-2 production of normal T cells and that administration of exogenous DHEA or IL-2 via a vaccinia construct to mice with murine lupus dramatically reverses their clinical autoimmune diseases. Dehydroepiandrosterone 241-245 interleukin 2 Mus musculus 170-174 7851019-2 1995 Recent studies of our own as well as others have shown that dehydroepiandrosterone (DHEA), an intermediate compound in testosterone synthesis, significantly up-regulates IL-2 production of T cells, and that administration of exogenous DHEA or IL-2 via a vaccinia construct to murine lupus dramatically reverses their clinical autoimmune diseases. Dehydroepiandrosterone 60-82 interleukin 2 Mus musculus 170-174 7851019-2 1995 Recent studies of our own as well as others have shown that dehydroepiandrosterone (DHEA), an intermediate compound in testosterone synthesis, significantly up-regulates IL-2 production of T cells, and that administration of exogenous DHEA or IL-2 via a vaccinia construct to murine lupus dramatically reverses their clinical autoimmune diseases. Dehydroepiandrosterone 60-82 interleukin 2 Mus musculus 243-247 7851019-2 1995 Recent studies of our own as well as others have shown that dehydroepiandrosterone (DHEA), an intermediate compound in testosterone synthesis, significantly up-regulates IL-2 production of T cells, and that administration of exogenous DHEA or IL-2 via a vaccinia construct to murine lupus dramatically reverses their clinical autoimmune diseases. Dehydroepiandrosterone 84-88 interleukin 2 Mus musculus 170-174 7851019-2 1995 Recent studies of our own as well as others have shown that dehydroepiandrosterone (DHEA), an intermediate compound in testosterone synthesis, significantly up-regulates IL-2 production of T cells, and that administration of exogenous DHEA or IL-2 via a vaccinia construct to murine lupus dramatically reverses their clinical autoimmune diseases. Dehydroepiandrosterone 84-88 interleukin 2 Mus musculus 243-247 7851019-2 1995 Recent studies of our own as well as others have shown that dehydroepiandrosterone (DHEA), an intermediate compound in testosterone synthesis, significantly up-regulates IL-2 production of T cells, and that administration of exogenous DHEA or IL-2 via a vaccinia construct to murine lupus dramatically reverses their clinical autoimmune diseases. Dehydroepiandrosterone 235-239 interleukin 2 Mus musculus 170-174 1351401-1 1992 We have investigated the ability of dehydroepiandrosterone (DHEA) to alter the production of interleukin-2 (IL-2) and to bind to a specific binding complex in antiCD3 epsilon activated T cells. Dehydroepiandrosterone 60-64 interleukin 2 Mus musculus 108-112 1331012-6 1992 In contrast, the inhibition of testosterone synthesis produced by either IL-2 or INF gamma plus TNF alpha could be reversed by 17 alpha-hydroxypregnenolone and dehydroepiandrosterone, but not by 22-hydroxycholesterol (P < 0.01). Dehydroepiandrosterone 160-182 interleukin 2 Mus musculus 73-77 1351401-1 1992 We have investigated the ability of dehydroepiandrosterone (DHEA) to alter the production of interleukin-2 (IL-2) and to bind to a specific binding complex in antiCD3 epsilon activated T cells. Dehydroepiandrosterone 36-58 interleukin 2 Mus musculus 93-106 1351401-1 1992 We have investigated the ability of dehydroepiandrosterone (DHEA) to alter the production of interleukin-2 (IL-2) and to bind to a specific binding complex in antiCD3 epsilon activated T cells. Dehydroepiandrosterone 36-58 interleukin 2 Mus musculus 108-112 1351401-1 1992 We have investigated the ability of dehydroepiandrosterone (DHEA) to alter the production of interleukin-2 (IL-2) and to bind to a specific binding complex in antiCD3 epsilon activated T cells. Dehydroepiandrosterone 60-64 interleukin 2 Mus musculus 93-106 1351401-5 1992 Five of the T-cell hybridomas tested both responded to DHEA treatment with increased production of IL-2 and also contained specific high affinity [3H]DHEA binding. Dehydroepiandrosterone 55-59 interleukin 2 Mus musculus 99-103 1351401-14 1992 We believe that DHEA is a steroid hormone that is directly involved in the regulation of IL-2 production by both normal and some T-cell hybridomas. Dehydroepiandrosterone 16-20 interleukin 2 Mus musculus 89-93 1833106-2 1991 Although it is well established that DHEA serves as an intermediate in sex steroid synthesis, recent studies in mice suggest that DHEA may also be a physiologic regulator of IL2 secretion. Dehydroepiandrosterone 130-134 interleukin 2 Mus musculus 174-177 1834253-7 1991 DHEA feeding prevented the generation of IL-2-responsive precursor cells in recipients of 10(6) BMC, but this inhibition was overcome in recipients of 20 x 10(6) BMC. Dehydroepiandrosterone 0-4 interleukin 2 Mus musculus 41-45 1834253-10 1991 Thus, DHEA appears to inhibit the generation of NK progenitors from more primitive stem cells, the differentiation of progenitors into IL-2-responsive precursors cells and the maturation of IL-2-responsive precursor cells into mature NK cells. Dehydroepiandrosterone 6-10 interleukin 2 Mus musculus 135-139 1834253-10 1991 Thus, DHEA appears to inhibit the generation of NK progenitors from more primitive stem cells, the differentiation of progenitors into IL-2-responsive precursors cells and the maturation of IL-2-responsive precursor cells into mature NK cells. Dehydroepiandrosterone 6-10 interleukin 2 Mus musculus 190-194 1830499-10 1991 Second, treatment of either aged mice or the T cells isolated from them with a combination of dehydroepiandrosterone and DHT restored the capacity of their T cells to produce IL-2, IL-4, and gamma IFN to levels equivalent to that of younger mice. Dehydroepiandrosterone 94-116 interleukin 2 Mus musculus 175-179 1828013-7 1991 The finding that treatment of thymectomized animals with the androgen steroid hormone dehydroepiandrosterone reestablished a normal IL-2-producing potential by their T cells makes it unlikely that the reduced capacity to produce IL-2 was secondary to a loss in fresh thymic emigrants. Dehydroepiandrosterone 86-108 interleukin 2 Mus musculus 132-136 1828013-7 1991 The finding that treatment of thymectomized animals with the androgen steroid hormone dehydroepiandrosterone reestablished a normal IL-2-producing potential by their T cells makes it unlikely that the reduced capacity to produce IL-2 was secondary to a loss in fresh thymic emigrants. Dehydroepiandrosterone 86-108 interleukin 2 Mus musculus 229-233 1833106-6 1991 In contrast to its effect on murine T cells, the IL2 enhancing effect of DHEA on human lymphocytes was limited to fresh CD4+ T cells and CD4+ clones; neither fresh CD8+ cells nor CD8+ clones were directly affected by DHEA treatment, although CD8+ cells stimulated in the presence of CD4+ cells and DHEA demonstrated enhanced cytotoxicity. Dehydroepiandrosterone 73-77 interleukin 2 Mus musculus 49-52 2140789-2 1990 Dehydroepiandrosterone is a natural enhancer of interleukin 2 synthesis by helper T cells. Dehydroepiandrosterone 0-22 interleukin 2 Mus musculus 48-61 2140789-7 1990 These findings suggest that DHEA, presumably through receptor-mediated mechanisms similar to other types of steroid hormones, may represent a natural and important regulator of IL 2 production in both normal and pathologic conditions. Dehydroepiandrosterone 28-32 interleukin 2 Mus musculus 177-181 31228660-6 2019 Furthermore, DHEA significantly increased the Th1 type cytokine (IL-2 and IFN-alpha) and decreased the Th2 type cytokine (IL-4 and IL-10) levels in LPS-induced mice or in primary cultured spleen T lymphocytes. Dehydroepiandrosterone 13-17 interleukin 2 Mus musculus 65-69