PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24055700-1 2014 2-Phosphonomethyl pentanedioic acid (2-PMPA) is a potent and selective inhibitor of glutamate carboxypeptidase-II, an enzyme which catabolizes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to N-acetylaspartate (NAA) and glutamate. 2-(phosphonomethyl)pentanedioic acid 0-35 folate hydrolase 1 Rattus norvegicus 84-113 28763226-1 2017 2-(Phosphonomethyl)pentanedioic acid (2-PMPA) is a potent and selective inhibitor of glutamate carboxypeptidase-II (GCPII) with efficacy in multiple neurological and psychiatric disease models, but its clinical utility is hampered by low brain penetration due to the inclusion of multiple acidic functionalities. 2-(phosphonomethyl)pentanedioic acid 0-36 folate hydrolase 1 Rattus norvegicus 85-114 28763226-1 2017 2-(Phosphonomethyl)pentanedioic acid (2-PMPA) is a potent and selective inhibitor of glutamate carboxypeptidase-II (GCPII) with efficacy in multiple neurological and psychiatric disease models, but its clinical utility is hampered by low brain penetration due to the inclusion of multiple acidic functionalities. 2-(phosphonomethyl)pentanedioic acid 0-36 folate hydrolase 1 Rattus norvegicus 116-121 28763226-1 2017 2-(Phosphonomethyl)pentanedioic acid (2-PMPA) is a potent and selective inhibitor of glutamate carboxypeptidase-II (GCPII) with efficacy in multiple neurological and psychiatric disease models, but its clinical utility is hampered by low brain penetration due to the inclusion of multiple acidic functionalities. 2-(phosphonomethyl)pentanedioic acid 38-44 folate hydrolase 1 Rattus norvegicus 85-114 28763226-1 2017 2-(Phosphonomethyl)pentanedioic acid (2-PMPA) is a potent and selective inhibitor of glutamate carboxypeptidase-II (GCPII) with efficacy in multiple neurological and psychiatric disease models, but its clinical utility is hampered by low brain penetration due to the inclusion of multiple acidic functionalities. 2-(phosphonomethyl)pentanedioic acid 38-44 folate hydrolase 1 Rattus norvegicus 116-121 24055700-1 2014 2-Phosphonomethyl pentanedioic acid (2-PMPA) is a potent and selective inhibitor of glutamate carboxypeptidase-II, an enzyme which catabolizes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to N-acetylaspartate (NAA) and glutamate. 2-(phosphonomethyl)pentanedioic acid 37-43 folate hydrolase 1 Rattus norvegicus 84-113 11166133-4 2001 Recently, a specific inhibitor of N-acetylated-alpha-linked acidic dipeptidase, 2-(phosphonomethyl)pentanedioic acid, has been reported. 2-(phosphonomethyl)pentanedioic acid 80-116 folate hydrolase 1 Rattus norvegicus 34-78 15953368-4 2005 The reduction of the H-effect by NAAG was completely removed when N-acetyl-beta-aspartylglutamate (betaNAAG) or 2-(phosphonomethyl)-pentanedioic acid (2-PMPA) was used to inhibit glutamate carboxypeptidase II (GCP II), a presynaptic Schwann cell membrane-associated ectoenzyme that hydrolyzes NAAG to glutamate and N-acetylaspartate. 2-(phosphonomethyl)pentanedioic acid 151-157 folate hydrolase 1 Rattus norvegicus 179-208 15953368-4 2005 The reduction of the H-effect by NAAG was completely removed when N-acetyl-beta-aspartylglutamate (betaNAAG) or 2-(phosphonomethyl)-pentanedioic acid (2-PMPA) was used to inhibit glutamate carboxypeptidase II (GCP II), a presynaptic Schwann cell membrane-associated ectoenzyme that hydrolyzes NAAG to glutamate and N-acetylaspartate. 2-(phosphonomethyl)pentanedioic acid 151-157 folate hydrolase 1 Rattus norvegicus 210-216 15019832-6 2004 Next, we treated rat adipocytes with 2-[phosphonomethy]pentanedionic acid (2-PMPA), a potent NAALADase inhibitor, and studied its effect on the distribution of GLUT4 and 3-O-methyl glucose (3OMG) flux. 2-(phosphonomethyl)pentanedioic acid 75-81 folate hydrolase 1 Rattus norvegicus 93-102 14607107-2 2003 It is hydrolysed by glutamate carboxypeptidase II (GCPII); thus, the GCP-II inhibitor 2-[phosphono-methyl]-pentanedioic acid (2-PMPA) protects endogenous NAAG from degradation, allowing its effects to be studied in vivo. 2-(phosphonomethyl)pentanedioic acid 86-124 folate hydrolase 1 Rattus norvegicus 20-49 14607107-2 2003 It is hydrolysed by glutamate carboxypeptidase II (GCPII); thus, the GCP-II inhibitor 2-[phosphono-methyl]-pentanedioic acid (2-PMPA) protects endogenous NAAG from degradation, allowing its effects to be studied in vivo. 2-(phosphonomethyl)pentanedioic acid 86-124 folate hydrolase 1 Rattus norvegicus 51-56 14607107-2 2003 It is hydrolysed by glutamate carboxypeptidase II (GCPII); thus, the GCP-II inhibitor 2-[phosphono-methyl]-pentanedioic acid (2-PMPA) protects endogenous NAAG from degradation, allowing its effects to be studied in vivo. 2-(phosphonomethyl)pentanedioic acid 86-124 folate hydrolase 1 Rattus norvegicus 69-75 14607107-2 2003 It is hydrolysed by glutamate carboxypeptidase II (GCPII); thus, the GCP-II inhibitor 2-[phosphono-methyl]-pentanedioic acid (2-PMPA) protects endogenous NAAG from degradation, allowing its effects to be studied in vivo. 2-(phosphonomethyl)pentanedioic acid 126-132 folate hydrolase 1 Rattus norvegicus 20-49 14607107-2 2003 It is hydrolysed by glutamate carboxypeptidase II (GCPII); thus, the GCP-II inhibitor 2-[phosphono-methyl]-pentanedioic acid (2-PMPA) protects endogenous NAAG from degradation, allowing its effects to be studied in vivo. 2-(phosphonomethyl)pentanedioic acid 126-132 folate hydrolase 1 Rattus norvegicus 51-56 14607107-2 2003 It is hydrolysed by glutamate carboxypeptidase II (GCPII); thus, the GCP-II inhibitor 2-[phosphono-methyl]-pentanedioic acid (2-PMPA) protects endogenous NAAG from degradation, allowing its effects to be studied in vivo. 2-(phosphonomethyl)pentanedioic acid 126-132 folate hydrolase 1 Rattus norvegicus 69-75 11805230-5 2002 In the present study, we determined the effect of a GCP II inhibitor, 2-(phosphono-methyl)-pentanedioic acid (2-PMPA), on allodynia and ectopic afferent discharges in an animal model of neuropathic pain. 2-(phosphonomethyl)pentanedioic acid 70-108 folate hydrolase 1 Rattus norvegicus 52-58 11805230-5 2002 In the present study, we determined the effect of a GCP II inhibitor, 2-(phosphono-methyl)-pentanedioic acid (2-PMPA), on allodynia and ectopic afferent discharges in an animal model of neuropathic pain. 2-(phosphonomethyl)pentanedioic acid 110-116 folate hydrolase 1 Rattus norvegicus 52-58 11557259-0 2001 Binding of the glutamate carboxypeptidase II (NAALADase) inhibitor 2-PMPA to rat brain membranes. 2-(phosphonomethyl)pentanedioic acid 67-73 folate hydrolase 1 Rattus norvegicus 15-44 11557259-1 2001 2-Phosphonomethyl pentanedioic acid (2-PMPA) is a potent and selective inhibitor of glutamate carboxypeptidase II (NAALADase), and has shown robust neuroprotective activity in both in vitro and in vivo models of ischemia. 2-(phosphonomethyl)pentanedioic acid 0-35 folate hydrolase 1 Rattus norvegicus 84-113 11557259-1 2001 2-Phosphonomethyl pentanedioic acid (2-PMPA) is a potent and selective inhibitor of glutamate carboxypeptidase II (NAALADase), and has shown robust neuroprotective activity in both in vitro and in vivo models of ischemia. 2-(phosphonomethyl)pentanedioic acid 37-43 folate hydrolase 1 Rattus norvegicus 84-113 11557259-9 2001 The binding of [(3)H]2-PMPA also showed tissue specificity in that tissues previously reported to be devoid of GCPII enzymatic activity were devoid of [(3)H]2-PMPA binding. 2-(phosphonomethyl)pentanedioic acid 21-27 folate hydrolase 1 Rattus norvegicus 111-116 11557259-10 2001 [(3)H]2-PMPA binding represents an additional probe for the study of GCPII activity, and may be useful as a high throughput screening assay. 2-(phosphonomethyl)pentanedioic acid 6-12 folate hydrolase 1 Rattus norvegicus 69-74 19887067-1 2010 We have recently reported that the endogenous mGlu2/3 agonist N-acetylaspartylglutamate (NAAG) and the N-acetylated-alpha-linked-acidic dipeptidase (NAALADase, a NAAG degradation enzyme) inhibitor 2-PMPA significantly inhibit cocaine self-administration and cocaine-induced reinstatement of drug-seeking behavior by attenuating cocaine-enhanced extracellular dopamine and glutamate in the nucleus accumbens. 2-(phosphonomethyl)pentanedioic acid 197-203 folate hydrolase 1 Rattus norvegicus 103-147 19887067-1 2010 We have recently reported that the endogenous mGlu2/3 agonist N-acetylaspartylglutamate (NAAG) and the N-acetylated-alpha-linked-acidic dipeptidase (NAALADase, a NAAG degradation enzyme) inhibitor 2-PMPA significantly inhibit cocaine self-administration and cocaine-induced reinstatement of drug-seeking behavior by attenuating cocaine-enhanced extracellular dopamine and glutamate in the nucleus accumbens. 2-(phosphonomethyl)pentanedioic acid 197-203 folate hydrolase 1 Rattus norvegicus 149-158 20575858-4 2000 Recently, a potent and selective NAALADase inhibitor termed 2-(phosphonomethyl)pentanedioic acid (2-PMPA) was identified that has a 300 pM Ki for NAALADase inhibition. 2-(phosphonomethyl)pentanedioic acid 60-96 folate hydrolase 1 Rattus norvegicus 33-42 20575858-4 2000 Recently, a potent and selective NAALADase inhibitor termed 2-(phosphonomethyl)pentanedioic acid (2-PMPA) was identified that has a 300 pM Ki for NAALADase inhibition. 2-(phosphonomethyl)pentanedioic acid 60-96 folate hydrolase 1 Rattus norvegicus 146-155 20575858-4 2000 Recently, a potent and selective NAALADase inhibitor termed 2-(phosphonomethyl)pentanedioic acid (2-PMPA) was identified that has a 300 pM Ki for NAALADase inhibition. 2-(phosphonomethyl)pentanedioic acid 98-104 folate hydrolase 1 Rattus norvegicus 33-42 20575858-4 2000 Recently, a potent and selective NAALADase inhibitor termed 2-(phosphonomethyl)pentanedioic acid (2-PMPA) was identified that has a 300 pM Ki for NAALADase inhibition. 2-(phosphonomethyl)pentanedioic acid 98-104 folate hydrolase 1 Rattus norvegicus 146-155 10581082-2 1999 We demonstrate that the newly described NAALADase inhibitor 2-PMPA (2-(phosphonomethyl)pentanedioic acid) robustly protects against ischemic injury in a neuronal culture model of stroke and in rats after transient middle cerebral artery occlusion. 2-(phosphonomethyl)pentanedioic acid 60-66 folate hydrolase 1 Rattus norvegicus 40-49 10940354-0 2000 Neuroprotection produced by the NAALADase inhibitor 2-PMPA in rat cerebellar neurons. 2-(phosphonomethyl)pentanedioic acid 52-58 folate hydrolase 1 Rattus norvegicus 32-41 10940354-1 2000 The present study examined the neuroprotective actions of the N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) inhibitor 2-(phosphonomethyl)pentanedioic acid (2-PMPA) in four in vitro models of neurotoxicity. 2-(phosphonomethyl)pentanedioic acid 129-165 folate hydrolase 1 Rattus norvegicus 62-106 10940354-1 2000 The present study examined the neuroprotective actions of the N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) inhibitor 2-(phosphonomethyl)pentanedioic acid (2-PMPA) in four in vitro models of neurotoxicity. 2-(phosphonomethyl)pentanedioic acid 129-165 folate hydrolase 1 Rattus norvegicus 108-117 10940354-1 2000 The present study examined the neuroprotective actions of the N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) inhibitor 2-(phosphonomethyl)pentanedioic acid (2-PMPA) in four in vitro models of neurotoxicity. 2-(phosphonomethyl)pentanedioic acid 167-173 folate hydrolase 1 Rattus norvegicus 62-106 10940354-1 2000 The present study examined the neuroprotective actions of the N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) inhibitor 2-(phosphonomethyl)pentanedioic acid (2-PMPA) in four in vitro models of neurotoxicity. 2-(phosphonomethyl)pentanedioic acid 167-173 folate hydrolase 1 Rattus norvegicus 108-117 10940354-6 2000 Unlike 2-PMPA, the endogenous NAALADase substrate and mGlu(3) receptor agonist N-acetyl-aspartyl-glutamate (NAAG) was neuroprotective against all four injury mechanisms and compared to 2-PMPA, exhibited a different "phosphate effect" on neuroprotection. 2-(phosphonomethyl)pentanedioic acid 185-191 folate hydrolase 1 Rattus norvegicus 30-39 10581082-2 1999 We demonstrate that the newly described NAALADase inhibitor 2-PMPA (2-(phosphonomethyl)pentanedioic acid) robustly protects against ischemic injury in a neuronal culture model of stroke and in rats after transient middle cerebral artery occlusion. 2-(phosphonomethyl)pentanedioic acid 68-104 folate hydrolase 1 Rattus norvegicus 40-49 10581082-3 1999 Consistent with inhibition of NAALADase, we show that 2-PMPA increases NAAG and attenuates the ischemia-induced rise in glutamate. 2-(phosphonomethyl)pentanedioic acid 54-60 folate hydrolase 1 Rattus norvegicus 30-39 10528109-5 1999 We report that, at high concentrations (300 microM-30 mM), a folic acid hexaglutamate analog is dose-dependently toxic to dissociated rat cortical cultures and that this toxicity is reversed by 2-PMPA, a potent and selective NAALADase inhibitor. 2-(phosphonomethyl)pentanedioic acid 194-200 folate hydrolase 1 Rattus norvegicus 225-234 10668445-3 1999 Using the suture model of transient middle cerebral artery occlusion (MCAO) in rats, the prototype NAALADase inhibitor 2-(phosphonomethyl)pentanedioic acid (2-PMPA) dramatically reduced extracellular glutamate accumulation measured by microdialysis both during a 2-hour occlusion and during reperfusion, consistent with an effect on glutamate supply. 2-(phosphonomethyl)pentanedioic acid 119-155 folate hydrolase 1 Rattus norvegicus 99-108 10668445-3 1999 Using the suture model of transient middle cerebral artery occlusion (MCAO) in rats, the prototype NAALADase inhibitor 2-(phosphonomethyl)pentanedioic acid (2-PMPA) dramatically reduced extracellular glutamate accumulation measured by microdialysis both during a 2-hour occlusion and during reperfusion, consistent with an effect on glutamate supply. 2-(phosphonomethyl)pentanedioic acid 157-163 folate hydrolase 1 Rattus norvegicus 99-108