PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31994915-7	2022	In addition, a significant (p<.05) modulation of biomarkers of survival (Bcl-2) and apoptosis (cleaved caspase-3) by TDZD-8 was observed.	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	117-123	caspase 3	Rattus norvegicus	103-112	
25394244-11	2015	In the lung, TDZD-8 reduced the histological signs of tissue injury, inflammatory markers (cytokines), and neutrophil chemotaxis/infiltration; reduced GSK-3beta, nuclear factor-kappaB, and Akt activation; reduced caspase-3 and metalloproteinase-9 activation.	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	13-19	caspase 3	Rattus norvegicus	213-246	
22294054-9	2012	Finally, TDZD-8 and EPO significantly suppressed the enhanced apoptosis and activity of caspase 3 induced by 6-OHDA.	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	9-15	caspase 3	Rattus norvegicus	88-97	
20093356-8	2010	In rats, TDZD-8 inhibited ischemia-induced activation of GSK3beta, Bax, and caspase 3; ameliorated tubular and epithelial cell damage; and significantly protected renal function.	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	9-15	caspase 3	Rattus norvegicus	76-85