PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24525588-2 2014 Three kinds of new cyclane-aminols were introduced into the structure of HCPT, which modified strong cytotoxic HCPT into cyclane-aminol HCPT analogs with moderate cytotoxicity and improved selectivity toward DNA topoisomerase I inhibition in tumor cells. 10-hydroxycamptothecin 73-77 DNA topoisomerase I Rattus norvegicus 208-227 24525588-2 2014 Three kinds of new cyclane-aminols were introduced into the structure of HCPT, which modified strong cytotoxic HCPT into cyclane-aminol HCPT analogs with moderate cytotoxicity and improved selectivity toward DNA topoisomerase I inhibition in tumor cells. 10-hydroxycamptothecin 111-115 DNA topoisomerase I Rattus norvegicus 208-227