PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29434958-0	2018	Anticancer effects of 10-hydroxycamptothecin induce apoptosis of human osteosarcoma through activating caspase-3, p53 and cytochrome c pathways.	10-hydroxycamptothecin	22-44	caspase 3	Homo sapiens	103-112	
31642230-7	2019	CONCLUSION: The combination of 2-DG and HCPT can synergistically induce the apoptosis of breast cancer cells, which may be caused by inhibiting the energy generation of tumor cells, inhibiting the phosphorylation of Akt protein and enhancing the activity of caspase-3 protein.	10-hydroxycamptothecin	40-44	caspase 3	Homo sapiens	258-267	
29434958-6	2018	The anticancer effects of HCPT were demonstrated to significantly activate the protein expression of p53, PARP-1 and cytochrome c, and suppress Bcl-2 protein expression and promote the activity of caspase-9 and caspase-3 in human osteosarcoma cells.	10-hydroxycamptothecin	26-30	caspase 3	Homo sapiens	211-220	
29434958-7	2018	In conclusion, the anticancer effects of HCPT appear to induce the apoptosis of human osteosarcoma cells through the activation of the caspase-3, p53 and cytochrome c pathways.	10-hydroxycamptothecin	41-45	caspase 3	Homo sapiens	135-144	
26639236-0	2016	10-Hydroxycamptothecin induces apoptosis in human neuroblastoma SMS-KCNR cells through p53, cytochrome c and caspase 3 pathways.	10-hydroxycamptothecin	0-22	caspase 3	Homo sapiens	109-118	
11129738-5	2000	Both caspase-1 and caspase-3 were activated in Hep G2 cells by HCPT treatment, suggesting that caspase-1 and caspase-3 are involved in the process of apoptosis in Hep G2 cells, and may be the main effectors of the apoptosis.	10-hydroxycamptothecin	63-67	caspase 3	Homo sapiens	19-28	
11129738-5	2000	Both caspase-1 and caspase-3 were activated in Hep G2 cells by HCPT treatment, suggesting that caspase-1 and caspase-3 are involved in the process of apoptosis in Hep G2 cells, and may be the main effectors of the apoptosis.	10-hydroxycamptothecin	63-67	caspase 3	Homo sapiens	109-118